RPS13
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| Ribosomal protein S13 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | RPS13 ; | ||||||||||
| External IDs | Template:OMIM5 HomoloGene: 38660 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Ribosomal protein S13, also known as RPS13, is a human gene.[1]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[1]
References
Further reading
- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. PMID 8722009.
- Suzuki K, Olvera J, Wool IG (1990). "The primary structure of rat ribosomal protein S13". Biochem. Biophys. Res. Commun. 171 (2): 519–24. PMID 2403345.
- Chadéneau C, LeMoullac B, Denis MG (1993). "Cloning and analysis of the human S13 ribosomal protein cDNA". Nucleic Acids Res. 21 (12): 2945. PMID 8332508.
- Vladimirov SN, Ivanov AV, Karpova GG; et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. PMID 8706699.
- Kenmochi N, Higa S, Yoshihama M, Tanaka T (1996). "U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene". Biochem. Biophys. Res. Commun. 228 (2): 371–4. doi:10.1006/bbrc.1996.1668. PMID 8920921.
- Kenmochi N, Kawaguchi T, Rozen S; et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. PMID 9582194.
- Caldwell GM, Eddy RL, Day CD; et al. (2001). "Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1-->p14". Cytogenet. Cell Genet. 92 (1–2): 103–7. PMID 11306805.
- Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.
- Kang MJ, Ahn HS, Lee JY; et al. (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Lundgren J, Masson P, Realini CA, Young P (2003). "Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13". Mol. Cell. Biol. 23 (15): 5320–30. PMID 12861018.
- Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Shi Y, Zhai H, Wang X; et al. (2004). "Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis". Exp. Cell Res. 296 (2): 337–46. doi:10.1016/j.yexcr.2004.02.009. PMID 15149863.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Malygin A, Parakhnevitch N, Karpova G (2005). "Human ribosomal protein S13: cloning, expression, refolding, and structural stability". Biochim. Biophys. Acta. 1747 (1): 93–7. doi:10.1016/j.bbapap.2004.10.001. PMID 15680243.
- Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMID 15883184.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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