RNF4

Ring finger protein 4
Identifiers
Symbols	RNF4 ; RES4-26; SNURF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37711
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ring finger protein 4, also known as RNF4, is a human gene.

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.

See also

• RING finger domain

Further reading

• Chiariotti L, Benvenuto G, Fedele M; et al. (1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–65. doi:10.1006/geno.1997.5105. PMID 9479498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moilanen AM, Poukka H, Karvonen U; et al. (1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Mol. Cell. Biol. 18 (9): 5128–39. PMID 9710597.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hadano S, Ishida Y, Ikeda JE (1998). "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3". DNA Res. 5 (3): 177–86. PMID 9734812.CS1 maint: Multiple names: authors list (link)
• Poukka H, Aarnisalo P, Santti H; et al. (2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". J. Biol. Chem. 275 (1): 571–9. PMID 10617653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fedele M, Benvenuto G, Pero R; et al. (2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". J. Biol. Chem. 275 (11): 7894–901. PMID 10713105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galili N, Nayak S, Epstein JA, Buck CA (2000). "Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region". Dev. Dyn. 218 (1): 102–11. doi:10.1002/(SICI)1097-0177(200005)218:1<102::AID-DVDY9>3.0.CO;2-A. PMID 10822263.CS1 maint: Multiple names: authors list (link)
• Lyngsø C, Bouteiller G, Damgaard CK; et al. (2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". J. Biol. Chem. 275 (34): 26144–9. doi:10.1074/jbc.M003405200. PMID 10849425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Häkli M, Karvonen U, Jänne OA, Palvimo JJ (2001). "The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity". J. Biol. Chem. 276 (26): 23653–60. doi:10.1074/jbc.M009891200. PMID 11319220.CS1 maint: Multiple names: authors list (link)
• Saville B, Poukka H, Wormke M; et al. (2002). "Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein". J. Biol. Chem. 277 (4): 2485–97. doi:10.1074/jbc.M109021200. PMID 11696545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pero R, Lembo F, Palmieri EA; et al. (2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". J. Biol. Chem. 277 (5): 3280–5. doi:10.1074/jbc.M109491200. PMID 11719514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan W, Hirvonen-Santti SJ, Palvimo JJ; et al. (2003). "Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation". Mech. Dev. 118 (1–2): 247–53. PMID 12351196.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pero R, Lembo F, Chieffi P; et al. (2004). "Translational regulation of a novel testis-specific RNF4 transcript". Mol. Reprod. Dev. 66 (1): 1–7. doi:10.1002/mrd.10322. PMID 12874792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaiser FJ, Möröy T, Chang GT; et al. (2003). "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor". J. Biol. Chem. 278 (40): 38780–5. doi:10.1074/jbc.M306259200. PMID 12885770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin DY, Fang HI, Ma AH; et al. (2004). "Negative modulation of androgen receptor transcriptional activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• RNF4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)