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{{Infobox_gene}}
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'''Receptor-interacting serine/threonine-protein kinase 2''' is an [[enzyme]] that in humans is encoded by the ''RIPK2'' [[gene]].<ref name="pmid9575181">{{cite journal |vauthors=Inohara N, del Peso L, Koseki T, Chen S, Nunez G | title = RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis | journal = J Biol Chem | volume = 273 | issue = 20 | pages = 12296–300 |date=Jun 1998 | pmid = 9575181 | pmc =  | doi =10.1074/jbc.273.20.12296  }}</ref><ref name="pmid9705938">{{cite journal |vauthors=Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J | title = Identification of CARDIAK, a RIP-like kinase that associates with caspase-1 | journal = Curr Biol | volume = 8 | issue = 15 | pages = 885–8 |date=Nov 1998 | pmid = 9705938 | pmc =  | doi =10.1016/S0960-9822(07)00352-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Receptor-interacting serine-threonine kinase 2
| HGNCid = 10020
| Symbol = RIPK2
| AltSymbols =; CCK; CARD3; CARDIAK; GIG30; RICK; RIP2
| OMIM = 603455
| ECnumber = 
| Homologene = 37856
| MGIid = 1891456
| GeneAtlas_image1 = PBB_GE_RIPK2_209544_at_tn.png
| GeneAtlas_image2 = PBB_GE_RIPK2_209545_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030274 |text = LIM domain binding}} {{GNF_GO|id=GO:0050700 |text = CARD domain binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8767
    | Hs_Ensembl = ENSG00000104312
    | Hs_RefseqProtein = NP_003812
    | Hs_RefseqmRNA = NM_003821
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 90839173
    | Hs_GenLoc_end = 90872432
    | Hs_Uniprot = O43353
    | Mm_EntrezGene = 192656
    | Mm_Ensembl = ENSMUSG00000041135
    | Mm_RefseqmRNA = NM_138952
    | Mm_RefseqProtein = NP_620402
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 16049889
    | Mm_GenLoc_end = 16090790
    | Mm_Uniprot = A1A4B5
  }}
}}
'''Receptor-interacting serine-threonine kinase 2''', also known as '''RIPK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767| accessdate = }}</ref>
 
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.<ref name="entrez">{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767| accessdate = }}</ref>
| summary_text = This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal [[caspase recruitment domain]] (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of [[NF-κB]] and inducer of apoptosis in response to various stimuli.<ref name="entrez" />
}}
}}
==Interactions==
RIPK2 has been shown to [[Protein-protein interaction|interact]] with [[BIRC2]].<ref name=pmid9705938 /><ref name=pmid9642260>{{cite journal |last=McCarthy |first=J V |authorlink= |author2=Ni J |author3=Dixit V M  |date=Jul 1998 |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase |journal=J. Biol. Chem. |volume=273 |issue=27 |pages=16968–75 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9642260 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.273.27.16968 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Medzhitov R, Janeway C |title=Innate immune recognition: mechanisms and pathways. |journal=Immunol. Rev. |volume=173 |issue=  |pages= 89-97 |year= 2000 |pmid= 10719670 |doi=  }}
*{{cite journal  |vauthors=Medzhitov R, Janeway C |title=Innate immune recognition: mechanisms and pathways |journal=Immunol. Rev. |volume=173 |issue=  |pages= 89–97 |year= 2000 |pmid= 10719670 |doi=10.1034/j.1600-065X.2000.917309.x }}
*{{cite journal  | author=Dufner A, Mak TW |title=CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 797-800 |year= 2006 |pmid= 16582588 |doi= }}
*{{cite journal  |vauthors=Dufner A, Mak TW |title=CARD tricks: controlling the interactions of CARD6 with RICK and microtubules |journal=Cell Cycle |volume=5 |issue= 8 |pages= 797–800 |year= 2006 |pmid= 16582588 |doi=10.4161/cc.5.8.2635 }}
*{{cite journal  | author=Inohara N, del Peso L, Koseki T, ''et al.'' |title=RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12296-300 |year= 1998 |pmid= 9575181 |doi= }}
*{{cite journal  |vauthors=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968–75 |year= 1998 |pmid= 9642260 |doi=10.1074/jbc.273.27.16968 }}
*{{cite journal  | author=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968-75 |year= 1998 |pmid= 9642260 |doi= }}
*{{cite journal   |vauthors=Bertin J, Nir WJ, Fischer CM, etal |title=Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12955–8 |year= 1999 |pmid= 10224040 |doi=10.1074/jbc.274.19.12955 }}
*{{cite journal  | author=Thome M, Hofmann K, Burns K, ''et al.'' |title=Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. |journal=Curr. Biol. |volume=8 |issue= 15 |pages= 885-8 |year= 1998 |pmid= 9705938 |doi= }}
*{{cite journal   |vauthors=Inohara N, Koseki T, del Peso L, etal |title=Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14560–7 |year= 1999 |pmid= 10329646 |doi=10.1074/jbc.274.21.14560 }}
*{{cite journal | author=Bertin J, Nir WJ, Fischer CM, ''et al.'' |title=Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12955-8 |year= 1999 |pmid= 10224040 |doi=  }}
*{{cite journal  |vauthors=Navas TA, Baldwin DT, Stewart TA |title=RIP2 is a Raf1-activated mitogen-activated protein kinase kinase |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33684–90 |year= 1999 |pmid= 10559258 |doi=10.1074/jbc.274.47.33684 }}
*{{cite journal | author=Inohara N, Koseki T, del Peso L, ''et al.'' |title=Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14560-7 |year= 1999 |pmid= 10329646 |doi=  }}
*{{cite journal   |vauthors=Inohara N, Koseki T, Lin J, etal |title=An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27823–31 |year= 2000 |pmid= 10880512 |doi= 10.1074/jbc.M003415200 }}
*{{cite journal  | author=Navas TA, Baldwin DT, Stewart TA |title=RIP2 is a Raf1-activated mitogen-activated protein kinase kinase. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33684-90 |year= 1999 |pmid= 10559258 |doi=  }}
*{{cite journal   |vauthors=Ogura Y, Inohara N, Benito A, etal |title=Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4812–8 |year= 2001 |pmid= 11087742 |doi= 10.1074/jbc.M008072200 }}
*{{cite journal | author=Inohara N, Koseki T, Lin J, ''et al.'' |title=An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27823-31 |year= 2000 |pmid= 10880512 |doi= 10.1074/jbc.M003415200 }}
*{{cite journal  |vauthors=Lee SH, Stehlik C, Reed JC |title=Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34495–500 |year= 2001 |pmid= 11432859 |doi= 10.1074/jbc.M101415200 }}
*{{cite journal | author=Ogura Y, Inohara N, Benito A, ''et al.'' |title=Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4812-8 |year= 2001 |pmid= 11087742 |doi= 10.1074/jbc.M008072200 }}
*{{cite journal   |vauthors=Khursigara G, Bertin J, Yano H, etal |title=A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2 |journal=J. Neurosci. |volume=21 |issue= 16 |pages= 5854–63 |year= 2001 |pmid= 11487608 |doi=  }}
*{{cite journal  | author=Lee SH, Stehlik C, Reed JC |title=Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34495-500 |year= 2001 |pmid= 11432859 |doi= 10.1074/jbc.M101415200 }}
*{{cite journal  |vauthors=Andersson L, Scharin Tang M, |title=Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia |journal=Cardiovasc Res. |volume=107 |issue= 4 |pages= 478–86 |year= 2015 |pmid= 26130752 |doi=10.1093/cvr/cvv186  }}
*{{cite journal | author=Khursigara G, Bertin J, Yano H, ''et al.'' |title=A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2. |journal=J. Neurosci. |volume=21 |issue= 16 |pages= 5854-63 |year= 2001 |pmid= 11487608 |doi=  }}
*{{cite journal  |vauthors=Druilhe A, Srinivasula SM, Razmara M, etal |title=Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins |journal=Cell Death Differ. |volume=8 |issue= 6 |pages= 649–57 |year= 2001 |pmid= 11536016 |doi= 10.1038/sj.cdd.4400881 }}
*{{cite journal  | author=Druilhe A, Srinivasula SM, Razmara M, ''et al.'' |title=Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. |journal=Cell Death Differ. |volume=8 |issue= 6 |pages= 649-57 |year= 2001 |pmid= 11536016 |doi= 10.1038/sj/cdd/4400881 }}
*{{cite journal   |vauthors=Chin AI, Dempsey PW, Bruhn K, etal |title=Involvement of receptor-interacting protein 2 in innate and adaptive immune responses |journal=Nature |volume=416 |issue= 6877 |pages= 190–4 |year= 2002 |pmid= 11894097 |doi= 10.1038/416190a }}
*{{cite journal | author=Chin AI, Dempsey PW, Bruhn K, ''et al.'' |title=Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. |journal=Nature |volume=416 |issue= 6877 |pages= 190-4 |year= 2002 |pmid= 11894097 |doi= 10.1038/416190a }}
*{{cite journal   |vauthors=Kobayashi K, Inohara N, Hernandez LD, etal |title=RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems |journal=Nature |volume=416 |issue= 6877 |pages= 194–9 |year= 2002 |pmid= 11894098 |doi= 10.1038/416194a |bibcode=2002Natur.416..194K }}
*{{cite journal | author=Kobayashi K, Inohara N, Hernandez LD, ''et al.'' |title=RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. |journal=Nature |volume=416 |issue= 6877 |pages= 194-9 |year= 2002 |pmid= 11894098 |doi= 10.1038/416194a }}
*{{cite journal  |vauthors=Munz B, Hildt E, Springer ML, Blau HM |title=RIP2, a Checkpoint in Myogenic Differentiation |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5879–86 |year= 2002 |pmid= 12138198 |doi=10.1128/MCB.22.16.5879-5886.2002  | pmc=133983 }}
*{{cite journal  | author=Munz B, Hildt E, Springer ML, Blau HM |title=RIP2, a checkpoint in myogenic differentiation. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5879-86 |year= 2002 |pmid= 12138198 |doi=  }}
*{{cite journal   |vauthors=Yoo NJ, Park WS, Kim SY, etal |title=Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1 |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 652–8 |year= 2003 |pmid= 12459189 |doi=10.1016/S0006-291X(02)02714-6 }}
*{{cite journal | author=Yoo NJ, Park WS, Kim SY, ''et al.'' |title=Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 652-8 |year= 2003 |pmid= 12459189 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Chen YR, Clark AC |title=Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK |journal=Biochemistry |volume=42 |issue= 20 |pages= 6310–20 |year= 2003 |pmid= 12755636 |doi= 10.1021/bi0340752 }}
*{{cite journal  | author=Chen YR, Clark AC |title=Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK. |journal=Biochemistry |volume=42 |issue= 20 |pages= 6310-20 |year= 2003 |pmid= 12755636 |doi= 10.1021/bi0340752 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 08:42, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.[1][2][3]

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.[3]

Interactions

RIPK2 has been shown to interact with BIRC2.[2][4]

References

  1. ↑ Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem. 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181.
  2. ↑ 2.0 2.1 Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol. 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938.
  3. ↑ 3.0 3.1 "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2".
  4. ↑ McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. UNITED STATES. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260.

Further reading



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