RICS (gene)

Rho GTPase-activating protein
Identifiers
Symbols	RICS ; GC-GAP; GRIT; KIAA0712; MGC1892; p200RhoGAP; p250GAP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8812
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE RICS 203431 s at tn.png
File:PBB GE RICS 210791 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Rho GTPase-activating protein, also known as RICS, is a human gene.

RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003).[supplied by OMIM]

Further reading

• Hayashi T, Okabe T, Nasu-Nishimura Y; et al. (2007). "PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development". Genes Cells. 12 (8): 929–39. doi:10.1111/j.1365-2443.2007.01101.x. PMID 17663722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benzinger A, Muster N, Koch HB; et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakazawa T, Watabe AM, Tezuka T; et al. (2004). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling". Mol. Biol. Cell. 14 (7): 2921–34. doi:10.1091/mbc.E02-09-0623. PMID 12857875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao C, Ma H, Bossy-Wetzel E; et al. (2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". J. Biol. Chem. 278 (36): 34641–53. doi:10.1074/jbc.M304594200. PMID 12819203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniguchi S, Liu H, Nakazawa T; et al. (2003). "p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn". Biochem. Biophys. Res. Commun. 306 (1): 151–5. PMID 12788081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okabe T, Nakamura T, Nishimura YN; et al. (2003). "RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling". J. Biol. Chem. 278 (11): 9920–7. doi:10.1074/jbc.M208872200. PMID 12531901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gardiner EM, Pestonjamasp KN, Bohl BP; et al. (2003). "Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis". Curr. Biol. 12 (23): 2029–34. PMID 12477392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moon SY, Zang H, Zheng Y (2003). "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP". J. Biol. Chem. 278 (6): 4151–9. doi:10.1074/jbc.M207789200. PMID 12454018.CS1 maint: Multiple names: authors list (link)
• Nakamura T, Komiya M, Sone K; et al. (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. 22 (24): 8721–34. PMID 12446789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. PMID 9872452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)