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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.[1][2][3]


RIC8A has been shown to interact with GNAO1,[4] GNA13,[5][4] GNAQ,[4][6] GNAS complex locus,[6] GNAI2,[4] GNAI1[4] and GNAI3.[4]


  1. Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMID 10985349.
  2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  3. "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
  5. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.
  6. 6.0 6.1 Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. ISSN 0021-9541. PMID 12652642.

Further reading