RIC8A: Difference between revisions

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{{Infobox_gene}}
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'''Resistance to inhibitors of cholinesterase-8A (Ric-8A)''', also known as '''Synembryn-A''', is a [[protein]] that in humans is encoded by the ''RIC8A'' [[gene]].<ref name="pmid10985349">{{cite journal |vauthors=Miller KG, Emerson MD, McManus JR, Rand JB | title = RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system | journal = Neuron | volume = 27 | issue = 2 | pages = 289–99 |date=Sep 2000 | pmid = 10985349 | pmc =  | doi =10.1016/S0896-6273(00)00037-4 }}</ref><ref name="pmid11230166">{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res | volume = 11 | issue = 3 | pages = 422–35 |date=Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60626| accessdate = }}</ref>
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| image =
| image_source =
| PDB =
| Name = Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
| HGNCid = 29550
| Symbol = RIC8A
| AltSymbols =; RIC8; MGC104517; MGC131931; MGC148073; MGC148074; synembryn
| OMIM = 609146
| ECnumber =
| Homologene = 23331
| MGIid = 2141866
  | GeneAtlas_image1 = PBB_GE_RIC8A_221647_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}}  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 60626
    | Hs_Ensembl = ENSG00000177963
    | Hs_RefseqProtein = NP_068751
    | Hs_RefseqmRNA = NM_021932
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 198530
    | Hs_GenLoc_end = 205113
    | Hs_Uniprot = Q9NPQ8
    | Mm_EntrezGene = 101489
    | Mm_Ensembl = ENSMUSG00000025485
    | Mm_RefseqmRNA = NM_053194
    | Mm_RefseqProtein = NP_444424
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 140708717
    | Mm_GenLoc_end = 140715051
    | Mm_Uniprot = Q3TIR3
  }}
}}
'''Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)''', also known as '''RIC8A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60626| accessdate = }}</ref>


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==Interactions==
RIC8A has been shown to [[Protein-protein interaction|interact]] with [[GNAO1]],<ref name=pmid12509430>{{cite journal |last=Tall |first=Gregory G |authorlink= |author2=Krumins Andrejs M |author3=Gilman Alfred G  |date=Mar 2003 |title=Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor |journal=J. Biol. Chem. |volume=278 |issue=10 |pages=8356–62 |publisher= |location = United States| issn = 0021-9258| pmid = 12509430 |doi = 10.1074/jbc.M211862200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GNA13]],<ref name=pmid21771786>{{cite journal | vauthors = Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY | title = Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization | journal = The Journal of Biological Chemistry | volume = 286 | issue = 35 | pages = 31055–61 | date = September 2011 | pmid = 21771786 | doi = 10.1074/jbc.M111.253427 }}</ref><ref name=pmid12509430/> [[GNAQ]],<ref name=pmid12509430/><ref name=pmid12652642>{{cite journal |last=Klattenhoff |first=Carla |authorlink= |author2=Montecino Martín |author3=Soto Ximena |author4=Guzmán Leonardo |author5=Romo Ximena |author6=García María Angeles |author7=Mellstrom Britt |author8=Naranjo José Ramón |author9=Hinrichs María Victoria |author10=Olate Juan  |date=May 2003 |title=Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol |journal=J. Cell. Physiol. |volume=195 |issue=2 |pages=151–7 |publisher= |location = United States| issn = 0021-9541| pmid = 12652642 |doi = 10.1002/jcp.10300 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GNAS complex locus]],<ref name=pmid12652642/> [[GNAI2]],<ref name=pmid12509430/> [[GNAI1]]<ref name=pmid12509430/> and [[GNAI3]].<ref name=pmid12509430/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Miller KG, Emerson MD, McManus JR, Rand JB |title=RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. |journal=Neuron |volume=27 |issue= 2 |pages= 289-99 |year= 2000 |pmid= 10985349 |doi= }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  |vauthors=Tall GG, Krumins AM, Gilman AG |title=Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8356–62 |year= 2003 |pmid= 12509430 |doi= 10.1074/jbc.M211862200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Klattenhoff C, Montecino M, Soto X, etal |title=Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. |journal=J. Cell. Physiol. |volume=195 |issue= 2 |pages= 151–7 |year= 2003 |pmid= 12652642 |doi= 10.1002/jcp.10300 }}
*{{cite journal  | author=Tall GG, Krumins AM, Gilman AG |title=Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8356-62 |year= 2003 |pmid= 12509430 |doi= 10.1074/jbc.M211862200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Klattenhoff C, Montecino M, Soto X, ''et al.'' |title=Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. |journal=J. Cell. Physiol. |volume=195 |issue= 2 |pages= 151-7 |year= 2003 |pmid= 12652642 |doi= 10.1002/jcp.10300 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Nishimura A, Okamoto M, Sugawara Y, etal |title=Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. |journal=Genes Cells |volume=11 |issue= 5 |pages= 487–98 |year= 2006 |pmid= 16629901 |doi= 10.1111/j.1365-2443.2006.00959.x }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Nishimura A, Okamoto M, Sugawara Y, ''et al.'' |title=Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. |journal=Genes Cells |volume=11 |issue= 5 |pages= 487-98 |year= 2006 |pmid= 16629901 |doi= 10.1111/j.1365-2443.2006.00959.x }}
*{{cite journal  |vauthors=Wang SC, Lai HL, etal |title=Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor. |journal=Biochem J |volume=406 |issue= 3 |pages= 383–8 |year= 2007 |pmid= 17593019 |doi= 10.1042/BJ20070512  | pmc=2049038 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 09:12, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.[1][2][3]


Interactions

RIC8A has been shown to interact with GNAO1,[4] GNA13,[5][4] GNAQ,[4][6] GNAS complex locus,[6] GNAI2,[4] GNAI1[4] and GNAI3.[4]

References

  1. ↑ Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMID 10985349.
  2. ↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  3. ↑ "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
  5. ↑ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMID 21771786.
  6. ↑ 6.0 6.1 Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. ISSN 0021-9541. PMID 12652642.

Further reading



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