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{{Infobox_gene}}
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'''Regulator of G-protein signaling 20''' is a [[protein]] that in humans is encoded by the ''RGS20'' [[gene]].<ref name="pmid9748279">{{cite journal |vauthors=Glick JL, Meigs TE, Miron A, Casey PJ | title = RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha | journal = J Biol Chem | volume = 273 | issue = 40 | pages = 26008–13 |date=Nov 1998 | pmid = 9748279 | pmc =  | doi =10.1074/jbc.273.40.26008 }}</ref><ref name="pmid9748280">{{cite journal |vauthors=Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM | title = RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily | journal = J Biol Chem | volume = 273 | issue = 40 | pages = 26014–25 |date=Nov 1998 | pmid = 9748280 | pmc =  | doi =10.1074/jbc.273.40.26014 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS20 regulator of G-protein signalling 20| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8601| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Regulator of G-protein signalling 20
| HGNCid = 14600
| Symbol = RGS20
| AltSymbols =; RGSZ1; ZGAP1
| OMIM = 607193
| ECnumber =
| Homologene = 2745
| MGIid = 1929866
  | GeneAtlas_image1 = PBB_GE_RGS20_210138_at_tn.png
  | Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8601
    | Hs_Ensembl = ENSG00000147509
    | Hs_RefseqProtein = NP_003693
    | Hs_RefseqmRNA = NM_003702
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 54926921
    | Hs_GenLoc_end = 55034416
    | Hs_Uniprot = O76081
    | Mm_EntrezGene = 58175
    | Mm_Ensembl = ENSMUSG00000002459
    | Mm_RefseqmRNA = NM_021374
    | Mm_RefseqProtein = NP_067349
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 4900326
    | Mm_GenLoc_end = 5009507
    | Mm_Uniprot = Q14A97
  }}
}}
'''Regulator of G-protein signalling 20''', also known as '''RGS20''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RGS20 regulator of G-protein signalling 20| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8601| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RGS20 regulator of G-protein signalling 20| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8601| accessdate = }}</ref>
| summary_text = Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RGS20 regulator of G-protein signalling 20| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8601| accessdate = }}</ref>
 
In melanocytic cells RGS20 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal  |vauthors=Hoek KS, Schlegel NC, Eichhoff OM, etal | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
}}
}}
==Interactions==
RGS20 has been shown to [[Protein-protein interaction|interact]] with [[GNAO1]]<ref name=pmid18407463>{{cite journal |last=Pagano |first=Mario |authorlink= |author2=Jordan J Dedrick |author3=Neves Susana R |author4=Nguyen Tracy |author5=Iyengar Ravi  |date=Jun 2008 |title=Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways |journal=Cell. Signal. |volume=20 |issue=6 |pages=1190–7 |publisher= |location = England| issn = 0898-6568| pmid = 18407463 |doi = 10.1016/j.cellsig.2008.02.008 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc=3107604}}</ref> and [[GNAZ]].<ref name=pmid9748279 /><ref name=pmid12414994>{{cite journal |doi=10.1242/jcs.00093 |last=Nagahama |first=Masami |authorlink= |author2=Usui Shihomi |author3=Shinohara Takashi |author4=Yamaguchi Tomohiro |author5=Tani Katsuko |author6=Tagaya Mitsuo  |date=Dec 2002 |title=Inactivation of Galpha(z) causes disassembly of the Golgi apparatus |journal=J. Cell Sci. |volume=115 |issue=Pt 23 |pages=4483–93 |publisher= |location = England| issn = 0021-9533| pmid = 12414994 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Glick JL, Meigs TE, Miron A, Casey PJ |title=RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26008-13 |year= 1998 |pmid= 9748279 |doi=  }}
*{{cite journal  |vauthors=Barker SA, Wang J, Sierra DA, Ross EM |title=RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. |journal=Genomics |volume=78 |issue= 3 |pages= 223–9 |year= 2002 |pmid= 11735229 |doi= 10.1006/geno.2001.6659 }}
*{{cite journal  | author=Wang J, Ducret A, Tu Y, ''et al.'' |title=RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26014-25 |year= 1998 |pmid= 9748280 |doi=  }}
*{{cite journal   |vauthors=Sierra DA, Gilbert DJ, Householder D, etal |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 }}
*{{cite journal  | author=Barker SA, Wang J, Sierra DA, Ross EM |title=RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. |journal=Genomics |volume=78 |issue= 3 |pages= 223-9 |year= 2002 |pmid= 11735229 |doi= 10.1006/geno.2001.6659 }}
*{{cite journal  |vauthors=Nixon AB, Grenningloh G, Casey PJ |title=The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 18127–33 |year= 2002 |pmid= 11882662 |doi= 10.1074/jbc.M201065200 }}
*{{cite journal | author=Sierra DA, Gilbert DJ, Householder D, ''et al.'' |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177-85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 }}
*{{cite journal   |vauthors=Wang Y, Ho G, Zhang JJ, etal |title=Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48325–32 |year= 2003 |pmid= 12379657 |doi= 10.1074/jbc.M206116200 }}
*{{cite journal  | author=Nixon AB, Grenningloh G, Casey PJ |title=The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 18127-33 |year= 2002 |pmid= 11882662 |doi= 10.1074/jbc.M201065200 }}
*{{cite journal   |vauthors=Nagahama M, Usui S, Shinohara T, etal |title=Inactivation of Galpha(z) causes disassembly of the Golgi apparatus. |journal=J. Cell Sci. |volume=115 |issue= Pt 23 |pages= 4483–93 |year= 2003 |pmid= 12414994 |doi=10.1242/jcs.00093 }}
*{{cite journal | author=Wang Y, Ho G, Zhang JJ, ''et al.'' |title=Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48325-32 |year= 2003 |pmid= 12379657 |doi= 10.1074/jbc.M206116200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Nagahama M, Usui S, Shinohara T, ''et al.'' |title=Inactivation of Galpha(z) causes disassembly of the Golgi apparatus. |journal=J. Cell. Sci. |volume=115 |issue= Pt 23 |pages= 4483-93 |year= 2003 |pmid= 12414994 |doi=  }}
*{{cite journal  |vauthors=Fischer T, De Vries L, Meerloo T, Farquhar MG |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8270–5 |year= 2003 |pmid= 12826607 |doi= 10.1073/pnas.1432965100 | pmc=166218 |bibcode=2003PNAS..100.8270F }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Fischer T, De Vries L, Meerloo T, Farquhar MG |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8270-5 |year= 2003 |pmid= 12826607 |doi= 10.1073/pnas.1432965100 }}
*{{cite journal   |vauthors=Xu GY, Hum WT, Sukits SF, etal |title=1H, 13C and 15N resonance assignments of human RGSZ1. |journal=J. Biomol. NMR |volume=28 |issue= 4 |pages= 409–10 |year= 2004 |pmid= 14872136 |doi= 10.1023/B:JNMR.0000015374.29659.f9 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Xu GY, Hum WT, Sukits SF, ''et al.'' |title=1H, 13C and 15N resonance assignments of human RGSZ1. |journal=J. Biomol. NMR |volume=28 |issue= 4 |pages= 409-10 |year= 2004 |pmid= 14872136 |doi= 10.1023/B:JNMR.0000015374.29659.f9 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ajit SK, Ramineni S, Edris W, etal |title=RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. |journal=Cell. Signal. |volume=19 |issue= 4 |pages= 723–30 |year= 2007 |pmid= 17126529 |doi= 10.1016/j.cellsig.2006.09.008 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ajit SK, Ramineni S, Edris W, ''et al.'' |title=RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. |journal=Cell. Signal. |volume=19 |issue= 4 |pages= 723-30 |year= 2007 |pmid= 17126529 |doi= 10.1016/j.cellsig.2006.09.008 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 08:45, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[1][2][3]

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][3]

In melanocytic cells RGS20 gene expression may be regulated by MITF.[4]

Interactions

RGS20 has been shown to interact with GNAO1[5] and GNAZ.[1][6]

References

  1. ↑ 1.0 1.1 Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J Biol Chem. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279.
  2. ↑ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J Biol Chem. 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280.
  3. ↑ 3.0 3.1 "Entrez Gene: RGS20 regulator of G-protein signalling 20".
  4. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  5. ↑ Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. England. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604. PMID 18407463.
  6. ↑ Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell Sci. England. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994.

Further reading



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