RCP9: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''DNA-directed RNA polymerase III subunit RPC9''' is an [[enzyme]] that in humans is encoded by the ''CRCP'' [[gene]].<ref name="pmid8622957">{{cite journal | vauthors = Luebke AE, Dahl GP, Roos BA, Dickerson IM | title = Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 8 | pages = 3455–60 |date=Jun 1996 | pmid = 8622957 | pmc = 39630 | doi =10.1073/pnas.93.8.3455 }}</ref><ref name="pmid10067875">{{cite journal | vauthors = Balkan W, Oates EL, Howard GA, Roos BA | title = Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein | journal = Endocrinology | volume = 140 | issue = 3 | pages = 1459–69 |date=Mar 1999 | pmid = 10067875 | pmc = | doi =10.1210/en.140.3.1459  }}</ref><ref name="pmid12482973">{{cite journal | vauthors = Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C | title = An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP | journal = Mol Cell Biol | volume = 23 | issue = 1 | pages = 195–205 |date=Dec 2002 | pmid = 12482973 | pmc = 140662 | doi =10.1128/MCB.23.1.195-205.2003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = Calcitonin gene-related peptide-receptor component protein
| HGNCid =
| Symbol = RCP9
| AltSymbols =; RCP; CGRP-RCP; CRCP; MGC111194
| OMIM = 606121
| ECnumber =
| Homologene = 40587
| MGIid = 1100818
| GeneAtlas_image1 = PBB_GE_RCP9_203898_at_tn.png
| GeneAtlas_image2 = PBB_GE_RCP9_203899_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004948 |text = calcitonin receptor activity}}
| Component = {{GNF_GO|id=GO:0001669 |text = acrosome}} {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007340 |text = acrosome reaction}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27297
    | Hs_Ensembl = ENSG00000126522
    | Hs_RefseqProtein = NP_001035737
    | Hs_RefseqmRNA = NM_001040647
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 65217294
    | Hs_GenLoc_end = 65255697
    | Hs_Uniprot = O75575
    | Mm_EntrezGene = 12909
    | Mm_Ensembl = ENSMUSG00000025532
    | Mm_RefseqmRNA = NM_007761
    | Mm_RefseqProtein = NP_031787
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 130314009
    | Mm_GenLoc_end = 130345492
    | Mm_Uniprot = O35427
  }}
}}
'''Calcitonin gene-related peptide-receptor component protein''', also known as '''RCP9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref>
| summary_text = This gene encodes a [[membrane protein]] that functions as part of a receptor complex for a small [[neuropeptide]] that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different [[isoforms]], have been characterized.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Yallampalli C, Chauhan M, Thota CS, ''et al.'' |title=Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. |journal=Trends Endocrinol. Metab. |volume=13 |issue= 6 |pages= 263-9 |year= 2003 |pmid= 12128288 |doi=  }}
*{{cite journal   |vauthors=Yallampalli C, Chauhan M, Thota CS, etal |title=Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity |journal=Trends Endocrinol. Metab. |volume=13 |issue= 6 |pages= 263–9 |year= 2003 |pmid= 12128288 |doi=  10.1016/s1043-2760(02)00563-5}}
*{{cite journal  | author=Luebke AE, Dahl GP, Roos BA, Dickerson IM |title=Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3455-60 |year= 1996 |pmid= 8622957 |doi=  }}
*{{cite journal   |vauthors=Evans BN, Rosenblatt MI, Mnayer LO, etal |title=CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31438–43 |year= 2000 |pmid= 10903324 |doi= 10.1074/jbc.M005604200 }}
*{{cite journal  | author=Balkan W, Oates EL, Howard GA, Roos BA |title=Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. |journal=Endocrinology |volume=140 |issue= 3 |pages= 1459-69 |year= 1999 |pmid= 10067875 |doi=  }}
*{{cite journal  | vauthors=Prado MA, Evans-Bain B, Oliver KR, Dickerson IM |title=The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction |journal=Peptides |volume=22 |issue= 11 |pages= 1773–81 |year= 2002 |pmid= 11754963 |doi=10.1016/S0196-9781(01)00517-4 }}
*{{cite journal | author=Evans BN, Rosenblatt MI, Mnayer LO, ''et al.'' |title=CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31438-43 |year= 2000 |pmid= 10903324 |doi= 10.1074/jbc.M005604200 }}
*{{cite journal   |vauthors=Moreno MJ, Terrón JA, Stanimirovic DB, etal |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270–80 |year= 2002 |pmid= 11804624 |doi=10.1016/S0028-3908(01)00176-9 }}
*{{cite journal  | author=Prado MA, Evans-Bain B, Oliver KR, Dickerson IM |title=The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. |journal=Peptides |volume=22 |issue= 11 |pages= 1773-81 |year= 2002 |pmid= 11754963 |doi=  }}
*{{cite journal   |vauthors=Harzenetter MD, Keller U, Beer S, etal |title=Regulation and function of the CGRP receptor complex in human granulopoiesis |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306–12 |year= 2002 |pmid= 11937264 |doi=10.1016/S0301-472X(02)00772-5 }}
*{{cite journal | author=Moreno MJ, Terrón JA, Stanimirovic DB, ''et al.'' |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture. |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270-80 |year= 2002 |pmid= 11804624 |doi=  }}
*{{cite journal   |vauthors=Hu P, Wu S, Sun Y, etal |title=Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044–55 |year= 2002 |pmid= 12391170 |doi=10.1128/MCB.22.22.8044-8055.2002 | pmc=134740  |url=http://repository.cshl.edu/28722/1/Kobayashi%20Myers%20Hernandez%20Molecular%20and%20Cellular%20Biology%202002.pdf }}
*{{cite journal | author=Harzenetter MD, Keller U, Beer S, ''et al.'' |title=Regulation and function of the CGRP receptor complex in human granulopoiesis. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306-12 |year= 2002 |pmid= 11937264 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Hu P, Wu S, Sun Y, ''et al.'' |title=Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044-55 |year= 2002 |pmid= 12391170 |doi=  }}
*{{cite journal   |vauthors=Hasbak P, Saetrum Opgaard O, Eskesen K, etal |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326–33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Siaut M, Zaros C, Levivier E, ''et al.'' |title=An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 195-205 |year= 2003 |pmid= 12482973 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Hasbak P, Saetrum Opgaard O, Eskesen K, ''et al.'' |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326-33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Zuccarello D, Morini E, Douzgou S, etal |title=Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism |journal=J. Endocrinol. Invest. |volume=27 |issue= 8 |pages= 760–4 |year= 2005 |pmid= 15636430 |doi=  10.1007/bf03347519}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Krämer HH, Schmidt K, Leis S, etal |title=Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin |journal=Peptides |volume=27 |issue= 4 |pages= 917–20 |year= 2006 |pmid= 16406141 |doi= 10.1016/j.peptides.2005.08.007 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Zuccarello D, Morini E, Douzgou S, ''et al.'' |title=Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism. |journal=J. Endocrinol. Invest. |volume=27 |issue= 8 |pages= 760-4 |year= 2005 |pmid= 15636430 |doi=  }}
*{{cite journal | author=Krämer HH, Schmidt K, Leis S, ''et al.'' |title=Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin. |journal=Peptides |volume=27 |issue= 4 |pages= 917-20 |year= 2006 |pmid= 16406141 |doi= 10.1016/j.peptides.2005.08.007 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 14:30, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.[1][2][3][4]

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4]

References

  1. ↑ Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.
  2. ↑ Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.
  3. ↑ Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.
  4. ↑ 4.0 4.1 "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".

Further reading



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