RCP9: Difference between revisions
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'''DNA-directed RNA polymerase III subunit RPC9''' is an [[enzyme]] that in humans is encoded by the ''CRCP'' [[gene]].<ref name="pmid8622957">{{cite journal | vauthors = Luebke AE, Dahl GP, Roos BA, Dickerson IM | title = Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 8 | pages = 3455–60 |date=Jun 1996 | pmid = 8622957 | pmc = 39630 | doi =10.1073/pnas.93.8.3455 }}</ref><ref name="pmid10067875">{{cite journal | vauthors = Balkan W, Oates EL, Howard GA, Roos BA | title = Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein | journal = Endocrinology | volume = 140 | issue = 3 | pages = 1459–69 |date=Mar 1999 | pmid = 10067875 | pmc = | doi =10.1210/en.140.3.1459 }}</ref><ref name="pmid12482973">{{cite journal | vauthors = Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C | title = An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP | journal = Mol Cell Biol | volume = 23 | issue = 1 | pages = 195–205 |date=Dec 2002 | pmid = 12482973 | pmc = 140662 | doi =10.1128/MCB.23.1.195-205.2003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref> | '''DNA-directed RNA polymerase III subunit RPC9''' is an [[enzyme]] that in humans is encoded by the ''CRCP'' [[gene]].<ref name="pmid8622957">{{cite journal | vauthors = Luebke AE, Dahl GP, Roos BA, Dickerson IM | title = Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 8 | pages = 3455–60 |date=Jun 1996 | pmid = 8622957 | pmc = 39630 | doi =10.1073/pnas.93.8.3455 }}</ref><ref name="pmid10067875">{{cite journal | vauthors = Balkan W, Oates EL, Howard GA, Roos BA | title = Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein | journal = Endocrinology | volume = 140 | issue = 3 | pages = 1459–69 |date=Mar 1999 | pmid = 10067875 | pmc = | doi =10.1210/en.140.3.1459 }}</ref><ref name="pmid12482973">{{cite journal | vauthors = Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C | title = An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP | journal = Mol Cell Biol | volume = 23 | issue = 1 | pages = 195–205 |date=Dec 2002 | pmid = 12482973 | pmc = 140662 | doi =10.1128/MCB.23.1.195-205.2003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" /> | | summary_text = This gene encodes a [[membrane protein]] that functions as part of a receptor complex for a small [[neuropeptide]] that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different [[isoforms]], have been characterized.<ref name="entrez" /> | ||
}} | }} | ||
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*{{cite journal |vauthors=Moreno MJ, Terrón JA, Stanimirovic DB, etal |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270–80 |year= 2002 |pmid= 11804624 |doi=10.1016/S0028-3908(01)00176-9 }} | *{{cite journal |vauthors=Moreno MJ, Terrón JA, Stanimirovic DB, etal |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270–80 |year= 2002 |pmid= 11804624 |doi=10.1016/S0028-3908(01)00176-9 }} | ||
*{{cite journal |vauthors=Harzenetter MD, Keller U, Beer S, etal |title=Regulation and function of the CGRP receptor complex in human granulopoiesis |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306–12 |year= 2002 |pmid= 11937264 |doi=10.1016/S0301-472X(02)00772-5 }} | *{{cite journal |vauthors=Harzenetter MD, Keller U, Beer S, etal |title=Regulation and function of the CGRP receptor complex in human granulopoiesis |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306–12 |year= 2002 |pmid= 11937264 |doi=10.1016/S0301-472X(02)00772-5 }} | ||
*{{cite journal |vauthors=Hu P, Wu S, Sun Y, etal |title=Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044–55 |year= 2002 |pmid= 12391170 |doi=10.1128/MCB.22.22.8044-8055.2002 | pmc=134740 }} | *{{cite journal |vauthors=Hu P, Wu S, Sun Y, etal |title=Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044–55 |year= 2002 |pmid= 12391170 |doi=10.1128/MCB.22.22.8044-8055.2002 | pmc=134740 |url=http://repository.cshl.edu/28722/1/Kobayashi%20Myers%20Hernandez%20Molecular%20and%20Cellular%20Biology%202002.pdf }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal |vauthors=Hasbak P, Saetrum Opgaard O, Eskesen K, etal |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326–33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 }} | *{{cite journal |vauthors=Hasbak P, Saetrum Opgaard O, Eskesen K, etal |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326–33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 }} | ||
Latest revision as of 14:30, 4 November 2018
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DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.[1][2][3][4]
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4]
References
- ↑ Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.
- ↑ Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.
- ↑ Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.
- ↑ 4.0 4.1 "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".
Further reading
- Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID 12128288.
- Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
- Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773–81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963.
- Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture". Neuropharmacology. 42 (2): 270–80. doi:10.1016/S0028-3908(01)00176-9. PMID 11804624.
- Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis". Exp. Hematol. 30 (4): 306–12. doi:10.1016/S0301-472X(02)00772-5. PMID 11937264.
- Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID 12490608.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism". J. Endocrinol. Invest. 27 (8): 760–4. doi:10.1007/bf03347519. PMID 15636430.
- Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin". Peptides. 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID 16406141.
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