RAC1

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Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
File:PBB Protein RAC1 image.jpg
PDB rendering based on 1ds6.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols RAC1 ; MGC111543; MIG5; TC-25; p21-Rac1
External IDs Template:OMIM5 Template:MGI HomoloGene69035
RNA expression pattern
File:PBB GE RAC1 208640 at tn.png
File:PBB GE RAC1 208641 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), also known as RAC1, is a human gene. Rac1 belongs to the Rho family of GTPases. It is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation (proposed to be necessary for maintaining epidermal stem cells).

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[1]

References

  1. "Entrez Gene: RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)".

Further reading

  • Benitah SA, Frye M, Glogauer M, Watt FM (2005). "Stem cell depletion through epidermal deletion of Rac1". Science. 309 (5736): 933–5. doi:10.1126/science.1113579. PMID 16081735.
  • Dorseuil O, Gacon G (1997). "[Signal transduction by Rac small G proteins in phagocytes]". C. R. Seances Soc. Biol. Fil. 191 (2): 237–46. PMID 9255350.
  • Ramakers GJ (2002). "Rho proteins, mental retardation and the cellular basis of cognition". Trends Neurosci. 25 (4): 191–9. PMID 11998687.

External links

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