Pyridoxine deficiency: Difference between revisions

Jump to navigation Jump to search
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
mNo edit summary
 
(3 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{CMG}}
{{Pyridoxine deficiency}}
{{CMG}}; {{AE}}


{{Editor Help}}
==[[Pyridoxine deficiency overview|Overview]]==


==Overview==
==[[Pyridoxine deficiency historical perspective|Historical Perspective]]==
{{Infobox_Disease
| Name          = Vitamin B6 deficiency
| Image          =  
| Caption        =
| DiseasesDB    = 13923
| ICD10          = {{ICD10|E|53|1|e|50}}
| ICD9          = {{ICD9|266.1}}
| ICDO          =
| OMIM          =
| MedlinePlus    =
| eMedicineSubj  = med
| eMedicineTopic = 1977
| MeshID        = D026681
}}
{{SI}}
The classic clinical syndrome for '''Pyridoxine deficiency''' (or '''B6 deficiency''') is a seborrheic dermatitis-like eruption, atrophic glossitis with ulceration, angular cheilitis, conjunctivitis, intertrigo, and neurologic symptoms of somnolence, confusion, and neuropathy.<ref>Andrews' Diseases of the Skin, 10th Edition, Elsevier.</ref>


Vitamin B6 is a co-factor for glutamic acid decarboxylase, an enzyme that converts Glutamate to GABA.  Therefore, the concurrent increase in the excitatory neurotransmitter, Glutamate, and decrease in inhibitory neurotransmitter, GABA, resultant from B6 deficiency, may manifest itself in the form of seizures.
==[[Pyridoxine deficiency classification|Classification]]==


==Causes==
==[[Pyridoxine deficiency pathophysiology|Pathophysiology]]==
*Supporters of a debated medical condition known as [[Pyroluria]] believe it may be one potential cause of vitamin B6 deficiency
*Another cause of vitamin B6 deficiency is the use of the tuberculostatic medication [[isoniazid]], and for this reason, it is recommended to supplement with vitamin B6 when using this drug. 
*Grumpiness and irritability are also often symptomatic of a deficiency according to "Body, Mind, and the B Vitamins" by Ruth Adams and Frank Murray.
*A [[meta-analysis]] of three databases ([[MEDLINE]], [[EMBASE]], and [[Cochrane Library]]), including only [[double-blind]], randomized controlled trials, found that vitamin B6 has a significant effect compared to [[placebo]]s in treating [[morning sickness]], similar to that of [[ginger]].<ref>[http://www.medicalnewstoday.com/medicalnews.php?newsid=22469 Pregnancy Morning Sickness - Ginger as Effective as Vitamin B6 (open)] [http://www.greenjournal.org/cgi/content/abstract/105/4/849 Effectiveness and Safety of Ginger in the Treatment of Pregnancy-Induced Nausea and Vomiting (subscription)], Borrelli ''et al.'',  ''Obstetrics & Gynecology'', 2005;105:849-856</ref>


===Diagnostic Testing for B6 Deficiency===
==[[Pyridoxine deficiency causes|Causes]]==
A positive diagnosis test for pyridoxine deficiency can be assertained by measuring [[erythrocyte]] levels of [[aspartate aminotransferase]] and transketolase in [[blood plasma|serum]].


== Differential Diagnosis ==
==[[Pyridoxine deficiency differential diagnosis|Differentiating Pyridoxine deficiency from other Diseases]]==
*Advanced Age
*Alcoholism
*Catabolic state
*[[Celiac Disease]]
*[[Chronic Renal Failure]]
*Drugs
*Extrahepatic biliary obstruction
*Hemodialysis
*[[Hepatocellular Carcinoma]]
*[[Hepatitis]]
*Hospitalization
*Hyperoxaluria
*Kidney transplant
*Peritoneal dialysis
*Severe malnutrition <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:310</ref>


==References==
==[[Pyridoxine deficiency epidemiology and demographics|Epidemiology and Demographics]]==
{{reflist|2}}


==[[Pyridoxine deficiency risk factors|Risk Factors]]==


{{SIB}}
==[[Pyridoxine deficiency screening|Screening]]==
{{Nutritional pathology}}


[[Category:Gastroenterology]]
==[[Pyridoxine deficiency natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


{{WikiDoc Help Menu}}
==Diagnosis==
{{WikiDoc Sources}}
[[Pyridoxine deficiency history and symptoms|History and Symptoms]] | [[Pyridoxine deficiency physical examination|Physical Examination]] | [[Pyridoxine deficiency  laboratory findings|Laboratory Findings]] | [[Pyridoxine deficiency electrocardiogram|Electrocardiogram]] | [[Pyridoxine deficiency x ray|X Ray]] | [[Pyridoxine deficiency  CT|CT]] | [[Pyridoxine deficiency MRI|MRI]] | [[Pyridoxine deficiency echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Pyridoxine deficiency other imaging findings|Other Imaging Findings]] | [[Pyridoxine deficiency other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Pyridoxine deficiency medical therapy|Medical Therapy]] | [[Pyridoxine deficiency surgery|Surgery]] | [[Pyridoxine deficiency primary prevention|Primary Prevention]] | [[Pyridoxine deficiency secondary prevention|Secondary Prevention]] | [[Pyridoxine deficiency cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Pyridoxine deficiency future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Pyridoxine deficiency case study one|Case #1]]
 
 
[[Category:Endocrinology]]
 
{{WH}}
{{WS}}

Latest revision as of 12:57, 25 July 2016

Pyridoxine deficiency Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pyridoxine deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Pyridoxine deficiency On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Pyridoxine deficiency

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Pyridoxine deficiency

CDC on Pyridoxine deficiency

Pyridoxine deficiency in the news

Blogs on Pyridoxine deficiency

Directions to Hospitals Treating Cushing’s disease

Risk calculators and risk factors for Pyridoxine deficiency

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pyridoxine deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Template:WH Template:WS