Psoriasis natural history, complications and prognosis: Difference between revisions
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==Complications== | ==Complications== | ||
Individuals with psoriasis may | Individuals with psoriasis may develop the following complications:<ref name="pmid20415823">{{cite journal |vauthors=Gisondi P, Del Giglio M, Cozzi A, Girolomoni G |title=Psoriasis, the liver, and the gastrointestinal tract |journal=Dermatol Ther |volume=23 |issue=2 |pages=155–9 |year=2010 |pmid=20415823 |doi=10.1111/j.1529-8019.2010.01310.x |url=}}</ref> | ||
* Psoriatic arthritis | |||
* Chronic inflammatory bowel disease | |||
* Non-alcoholic fatty liver disease | |||
* Celiac disease | |||
* Infections due medications given during the management of psoriasis | |||
* Anti-TNF medications given during the management of psoriasis may lead to: | |||
** Progressive multi-focal leukoencephlopathy | |||
** Optic neuritis | |||
** Transverse myelitis | |||
** Multiple sclerosis | |||
** Infections | |||
==Prognosis== | ==Prognosis== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural History
Complications
Individuals with psoriasis may develop the following complications:[1]
- Psoriatic arthritis
- Chronic inflammatory bowel disease
- Non-alcoholic fatty liver disease
- Celiac disease
- Infections due medications given during the management of psoriasis
- Anti-TNF medications given during the management of psoriasis may lead to:
- Progressive multi-focal leukoencephlopathy
- Optic neuritis
- Transverse myelitis
- Multiple sclerosis
- Infections
Prognosis
Psoriasis is a lifelong condition.[2] There is currently no cure but various treatments can help to control the symptoms. Many of the most effective agents used to treat severe psoriasis carry an increased risk of significant morbidity including skin cancers, lymphoma and liver disease. However, the majority of people's experience of psoriasis is that of minor localized patches, particularly on the elbows and knees, which can be treated with topical medication. Psoriasis does get worse over time but it is not possible to predict who will go on to develop extensive psoriasis or those in whom the disease may appear to vanish. Individuals will often experience flares and remissions throughout their lives. Controlling the signs and symptoms typically requires lifelong therapy.
According to one study,[3] psoriasis is linked to 2.5-fold increased risk for nonmelanoma skin cancer in men and women, with no preponderance of any specific histologic subtype of cancer. This, however could be linked to antipsoriatic treatment.
References
- ↑ Gisondi P, Del Giglio M, Cozzi A, Girolomoni G (2010). "Psoriasis, the liver, and the gastrointestinal tract". Dermatol Ther. 23 (2): 155–9. doi:10.1111/j.1529-8019.2010.01310.x. PMID 20415823.
- ↑ Jobling R (2007). "A patient's journey:Psoriasis". Br Med J. 334: 953&ndash, 4. doi:10.1136/bmj.39184.615150.802.
- ↑ Olsen JH, Frentz G, Møller H (1993). "[Psoriasis and cancer]". Ugeskr. Laeg. (in Danish). 155 (35): 2687–91. PMID 8212383.