Propacetamol

Revision as of 14:52, 13 April 2015 by Turky Alkathery (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Propacetamol
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
IV[1][2]
ATC code
Pharmacokinetic data
Elimination half-life2.4 hours [1]
ExcretionRenal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC14H20N2O3
Molar mass264.3202 g/mol
3D model (JSmol)
  (verify)

WikiDoc Resources for Propacetamol

Articles

Most recent articles on Propacetamol

Most cited articles on Propacetamol

Review articles on Propacetamol

Articles on Propacetamol in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Propacetamol

Images of Propacetamol

Photos of Propacetamol

Podcasts & MP3s on Propacetamol

Videos on Propacetamol

Evidence Based Medicine

Cochrane Collaboration on Propacetamol

Bandolier on Propacetamol

TRIP on Propacetamol

Clinical Trials

Ongoing Trials on Propacetamol at Clinical Trials.gov

Trial results on Propacetamol

Clinical Trials on Propacetamol at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Propacetamol

NICE Guidance on Propacetamol

NHS PRODIGY Guidance

FDA on Propacetamol

CDC on Propacetamol

Books

Books on Propacetamol

News

Propacetamol in the news

Be alerted to news on Propacetamol

News trends on Propacetamol

Commentary

Blogs on Propacetamol

Definitions

Definitions of Propacetamol

Patient Resources / Community

Patient resources on Propacetamol

Discussion groups on Propacetamol

Patient Handouts on Propacetamol

Directions to Hospitals Treating Propacetamol

Risk calculators and risk factors for Propacetamol

Healthcare Provider Resources

Symptoms of Propacetamol

Causes & Risk Factors for Propacetamol

Diagnostic studies for Propacetamol

Treatment of Propacetamol

Continuing Medical Education (CME)

CME Programs on Propacetamol

International

Propacetamol en Espanol

Propacetamol en Francais

Business

Propacetamol in the Marketplace

Patents on Propacetamol

Experimental / Informatics

List of terms related to Propacetamol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V.[2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol given orally.[3] 2 g of propacetamol are equivalent to 1g of paracetamol.[4]

See also

References

  1. 1.0 1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol" (pdf). British Journal of Clinical Pharmacology. 34 (1): 79–81. doi:10.1111/j.1365-2125.1992.tb04112.x. PMC 1381380. PMID 1633071.
  2. 2.0 2.1 Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]" (pdf). BMC Anesthesiology. 4 (1): 6. doi:10.1186/1471-2253-4-6. PMC 520811. PMID 15367329.
  3. Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery" (pdf). British Journal of Anaesthesiology. 94 (5): 642–648. doi:10.1093/bja/aei109. PMID 15790675.
  4. Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". International Journal of Clinical Pharmacology and Therapeutics. 42 (1): 50–57. doi:10.5414/cpp42050. PMID 14756388.