Prolactinoma epidemiology and demographics: Difference between revisions

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{{Prolactinoma}}
{{Prolactinoma}}
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==Overview==
==Overview==
The prevalence of [[prolactinoma]] in age group <20 years is 100 per 1,000,000 individuals worldwide.<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
About 45% of [[pituitary adenoma|pituitary adenomas]] are [[prolactinomas]], making it the most common type of all [[pituitary adenoma|pituitary adenomas]]. Worldwide, the [[prevalence]] of sporadic [[prolactinoma]] is 6 to 10 per 100,000 persons. The [[prevalence]] of [[prolactinoma]] in people less than 20 years old is 10 per 100,000 individuals worldwide. [[Prolactinoma]] most commonly affects women in reproductive age group (20 to 50 years). [[Prolactinoma]] is more common in females than males in people between 20 and 50 years old. Distribution among males and females becomes similar after age 50.
 
[[Prolactinoma]] most commomly affects age group 20 to 50 years.
 
[[Prolactinoma]] is more common in females than males in age group 20 to 50 years. Frequency becomes similar after age 50 years.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Prevalence===
===Prevalence===
*The [[prevalence]] of [[prolactinoma]] in age group <20 years is 100 per 1,000,000 individuals worldwide.<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
*45% of [[pituitary adenoma|pituitary adenomas]] are [[prolactinomas]], making it the most common type of all [[pituitary adenoma|pituitary adenomas]].<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
*Clinically significant [[pituitary tumors]] affect the health of approximately 14 out of 100,000 people in United States.
*Worldwide, the [[prevalence]] of sporadic [[prolactinoma]] ranges from a low of 6 persons per 100,000 persons to a high of 10 persons per 100,000 persons.
*Some [[growth hormone]] producing tumors also co-secrete [[prolactin]].
*Worldwide, the [[prevalence]] of [[prolactinoma]] in people less than 20 years old is 10 individuals per 100,000 individuals.
*Clinically significant [[pituitary tumors]] affect the health of approximately 14 people per 100,000 people in United States.
*Some [[growth hormone]]-producing tumors also co-secrete [[prolactin]].
*Microprolactinoma are much more common than macroprolactinoma.
*Microprolactinoma are much more common than macroprolactinoma.
===Incidence===
*Worldwide, the [[incidence]] of sporadic [[prolactinoma]] is 1 person per 100,000 persons per year.<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
===Age===
===Age===
*Prolactinoma commonly affects individuals of age 20 to 50 years.<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref><ref name="pmid7893282">{{cite journal| author=Mindermann T, Wilson CB| title=Age-related and gender-related occurrence of pituitary adenomas. | journal=Clin Endocrinol (Oxf) | year= 1994 | volume= 41 | issue= 3 | pages= 359-64 | pmid=7893282 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7893282  }} </ref>
* Age specific distribution of [[prolactinoma]] is as follows:<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref><ref name="pmid7893282">{{cite journal| author=Mindermann T, Wilson CB| title=Age-related and gender-related occurrence of pituitary adenomas. | journal=Clin Endocrinol (Oxf) | year= 1994 | volume= 41 | issue= 3 | pages= 359-64 | pmid=7893282 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7893282  }} </ref>
*Prolactinoma occur less commonly in age <20 years.
**[[Prolactinoma]] commonly affects individuals between 20 and 50 years old.
**[[Prolactinoma]] occur less commonly in people less than 20 years old, with a prevalence of 10 per 100,000 individuals. These [[tumors]] account for less than 2% of intracranial [[tumors]] in this age group.
 
===Gender===
===Gender===
*Men usually have microprolactinoma whereas men usually have macroadenoma.
*Women usually have microprolactinoma whereas men usually have [[Macroadenoma of the pituitary gland|macroadenoma]].<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
*Gender wise frequency of prolactinoma depends on age of individual:
*Gender-based frequency of [[prolactinoma]] depends on the age of the individual:
**Age group - 20 to 50 years
**'''Age group: 20 to 50 years'''
***Women are more commonly affected by prolactinoma than men. The women to men ratio is approximately 10:1.<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
***Women are more commonly affected by [[prolactinoma]] than men. The female to male ratio is approximately 10:1.<ref name="pmid16411062">{{cite journal| author=Ciccarelli A, Daly AF, Beckers A| title=The epidemiology of prolactinomas. | journal=Pituitary | year= 2005 | volume= 8 | issue= 1 | pages= 3-6 | pmid=16411062 | doi=10.1007/s11102-005-5079-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16411062  }} </ref>
***The highest prevalance of prolactinoma in women is in age group 20 to 30 years with a women to men ratio of approximately 14:1.
***Women aged 20 to 30 years have the highest prevalance of [[prolactinoma]], with a female to male ratio of approximately 14:1.
**Age group >50 years
**'''Age group: >50 years'''<ref name="pmid7893282">{{cite journal| author=Mindermann T, Wilson CB| title=Age-related and gender-related occurrence of pituitary adenomas. | journal=Clin Endocrinol (Oxf) | year= 1994 | volume= 41 | issue= 3 | pages= 359-64 | pmid=7893282 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7893282  }} </ref>
***Men and women are affected equally after age 50 years.<ref name="pmid7893282">{{cite journal| author=Mindermann T, Wilson CB| title=Age-related and gender-related occurrence of pituitary adenomas. | journal=Clin Endocrinol (Oxf) | year= 1994 | volume= 41 | issue= 3 | pages= 359-64 | pmid=7893282 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7893282  }} </ref>
***Men and women are affected equally after age 50 years.
***Prevalance of prolactinoma increases with age in men after age 50 years which peaks during age group 60 to 70 years. At this time women to men ratio is 1:3.
***The [[prevalence]] of [[prolactinoma]] increases with age in men after age 50 and peaks during ages 60 to 70 years. At this time, the female to male ratio is 1:3.
 


== References ==
== References ==
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Latest revision as of 23:49, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2], Faizan Sheraz, M.D. [3]

Overview

About 45% of pituitary adenomas are prolactinomas, making it the most common type of all pituitary adenomas. Worldwide, the prevalence of sporadic prolactinoma is 6 to 10 per 100,000 persons. The prevalence of prolactinoma in people less than 20 years old is 10 per 100,000 individuals worldwide. Prolactinoma most commonly affects women in reproductive age group (20 to 50 years). Prolactinoma is more common in females than males in people between 20 and 50 years old. Distribution among males and females becomes similar after age 50.

Epidemiology and Demographics

Prevalence

Incidence

Age

  • Age specific distribution of prolactinoma is as follows:[1][2]
    • Prolactinoma commonly affects individuals between 20 and 50 years old.
    • Prolactinoma occur less commonly in people less than 20 years old, with a prevalence of 10 per 100,000 individuals. These tumors account for less than 2% of intracranial tumors in this age group.

Gender

  • Women usually have microprolactinoma whereas men usually have macroadenoma.[1]
  • Gender-based frequency of prolactinoma depends on the age of the individual:
    • Age group: 20 to 50 years
      • Women are more commonly affected by prolactinoma than men. The female to male ratio is approximately 10:1.[1]
      • Women aged 20 to 30 years have the highest prevalance of prolactinoma, with a female to male ratio of approximately 14:1.
    • Age group: >50 years[2]
      • Men and women are affected equally after age 50 years.
      • The prevalence of prolactinoma increases with age in men after age 50 and peaks during ages 60 to 70 years. At this time, the female to male ratio is 1:3.

References

  1. 1.0 1.1 1.2 1.3 1.4 Ciccarelli A, Daly AF, Beckers A (2005). "The epidemiology of prolactinomas". Pituitary. 8 (1): 3–6. doi:10.1007/s11102-005-5079-0. PMID 16411062.
  2. 2.0 2.1 Mindermann T, Wilson CB (1994). "Age-related and gender-related occurrence of pituitary adenomas". Clin Endocrinol (Oxf). 41 (3): 359–64. PMID 7893282.

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