Difference between revisions of "Procollagen peptidase"

Jump to: navigation, search
({{Metalloproteinases}})
 
m (1 revision imported)
 
(3 intermediate revisions by 3 users not shown)
Line 18: Line 18:
 
|LocusSupplementaryData=
 
|LocusSupplementaryData=
 
}}
 
}}
'''Procollagen peptidase''' is an [[endopeptidase]] involved in the processing of [[collagen]].
+
'''Procollagen peptidase''' ({{EC number|3.4.24.14}}, ''procollagen N-terminal peptidase'', ''procollagen aminopeptidase'', ''aminoprocollagen peptidase'', ''aminoterminal procollagen peptidase'', ''procollagen aminoterminal protease'', ''procollagen N-terminal proteinase'', ''type I/II procollagen N-proteinase'', ''type III procollagen'') is an [[endopeptidase]] involved in the processing of [[collagen]]. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to [[dermatosparaxis]] or [[Ehlers–Danlos syndrome]].<ref>http://www.biology-online.org/dictionary/Procollagen_peptidase</ref>
  
==External links==
+
The enzyme is present in the skin of rats and humans.<ref name="Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen">{{cite journal | vauthors = Lapière CM, Lenaers A, Kohn LD | title = Procollagen peptidase: an enzyme excising the coordination peptides of procollagen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 68 | issue = 12 | pages = 3054–8 | date = December 1971 | pmid = 5289249 | pmc = 389589 | doi = 10.1073/pnas.68.12.3054 }}</ref>
 +
 
 +
== External links ==
 +
* The [[MEROPS]] online database for peptidases and their inhibitors: Procollagen C-Peptidase:[http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.005 M12.005], Procollagen N-Peptidase:[http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.301 M12.301]
 +
 
 +
== References ==
 +
{{Reflist}}
 +
 
 +
== External links ==
 
* {{MeshName|Procollagen+peptidase}}
 
* {{MeshName|Procollagen+peptidase}}
  
{{enzyme-stub}}
+
{{Fibrous proteins}}
{{enzymes}}
+
{{Metalloendopeptidases}}
{{Metalloproteinases}}
+
{{Enzymes}}
 +
{{Portal bar|Molecular and Cellular Biology|border=no}}
 +
 
 +
{{hydrolase-stub}}
 +
{{DEFAULTSORT:Procollagen Peptidase}}
 +
 
 +
[[Category:Peptidase]]
 +
[[Category:EC 3.4.24]]

Latest revision as of 09:08, 10 January 2019

procollagen (type III) N-endopeptidase
Identifiers
SymbolPCOLN3
Alt. symbolsPRSM1
Entrez5119
HUGO8740
OMIM164010
RefSeqNM_002768
UniProtQ9HD42
Other data
EC number3.4.24.14
LocusChr. 16 q24.3

Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]

The enzyme is present in the skin of rats and humans.[2]

External links

  • The MEROPS online database for peptidases and their inhibitors: Procollagen C-Peptidase:M12.005, Procollagen N-Peptidase:M12.301

References

  1. http://www.biology-online.org/dictionary/Procollagen_peptidase
  2. Lapière CM, Lenaers A, Kohn LD (December 1971). "Procollagen peptidase: an enzyme excising the coordination peptides of procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–8. doi:10.1073/pnas.68.12.3054. PMC 389589. PMID 5289249.

External links


Linked-in.jpg