Procollagen peptidase: Difference between revisions
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'''Procollagen peptidase''' ({{EC number|3.4.24.14}}, ''procollagen N-terminal peptidase'', ''procollagen aminopeptidase'', ''aminoprocollagen peptidase'', ''aminoterminal procollagen peptidase'', ''procollagen aminoterminal protease'', ''procollagen N-terminal proteinase'', ''type I/II procollagen N-proteinase'', ''type III procollagen'') is an [[endopeptidase]] involved in the processing of [[collagen]]. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to [[dermatosparaxis]] or [[Ehlers–Danlos syndrome]].<ref>http://www.biology-online.org/dictionary/Procollagen_peptidase</ref> | '''Procollagen peptidase''' ({{EC number|3.4.24.14}}, ''procollagen N-terminal peptidase'', ''procollagen aminopeptidase'', ''aminoprocollagen peptidase'', ''aminoterminal procollagen peptidase'', ''procollagen aminoterminal protease'', ''procollagen N-terminal proteinase'', ''type I/II procollagen N-proteinase'', ''type III procollagen'') is an [[endopeptidase]] involved in the processing of [[collagen]]. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to [[dermatosparaxis]] or [[Ehlers–Danlos syndrome]].<ref>http://www.biology-online.org/dictionary/Procollagen_peptidase</ref> | ||
The enzyme is present in the skin of rats and humans.<ref name="Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen">{{ | The enzyme is present in the skin of rats and humans.<ref name="Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen">{{cite journal | vauthors = Lapière CM, Lenaers A, Kohn LD | title = Procollagen peptidase: an enzyme excising the coordination peptides of procollagen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 68 | issue = 12 | pages = 3054–8 | date = December 1971 | pmid = 5289249 | pmc = 389589 | doi = 10.1073/pnas.68.12.3054 }}</ref> | ||
}}</ref> | |||
==External links== | == External links == | ||
* The [[MEROPS]] online database for peptidases and their inhibitors: Procollagen C-Peptidase:[http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.005 M12.005], Procollagen N-Peptidase:[http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.301 M12.301] | * The [[MEROPS]] online database for peptidases and their inhibitors: Procollagen C-Peptidase:[http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.005 M12.005], Procollagen N-Peptidase:[http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.301 M12.301] | ||
==References== | == References == | ||
{{Reflist}} | {{Reflist}} | ||
Latest revision as of 09:08, 10 January 2019
| procollagen (type III) N-endopeptidase | |
|---|---|
| Identifiers | |
| Symbol | PCOLN3 |
| Alt. symbols | PRSM1 |
| Entrez | 5119 |
| HUGO | 8740 |
| OMIM | 164010 |
| RefSeq | NM_002768 |
| UniProt | Q9HD42 |
| Other data | |
| EC number | 3.4.24.14 |
| Locus | Chr. 16 q24.3 |
Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]
The enzyme is present in the skin of rats and humans.[2]
External links
- The MEROPS online database for peptidases and their inhibitors: Procollagen C-Peptidase:M12.005, Procollagen N-Peptidase:M12.301
References
- ↑ http://www.biology-online.org/dictionary/Procollagen_peptidase
- ↑ Lapière CM, Lenaers A, Kohn LD (December 1971). "Procollagen peptidase: an enzyme excising the coordination peptides of procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–8. doi:10.1073/pnas.68.12.3054. PMC 389589. PMID 5289249.
External links
- Procollagen+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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