Primary hypertriglyceridemia: Difference between revisions
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==Biopsy== | ==Biopsy== | ||
==Medical Therapy== | ==Medical Therapy== | ||
The mainstay of therapy for hypertriglyceridemia includes life style modifications to lower the triglyceride levels to below 150 mg/dl. This can be achieved by various medical therapy of hypertriglyceridemia varies according to the level of triglycerides found in the body. Moderate increase i.e >500 can be treated by statins while severe increase that is >1000 need to be treated by using a fibrate as the primary treatment. | The mainstay of therapy for hypertriglyceridemia includes life style modifications to lower the triglyceride levels to below 150 mg/dl. This can be achieved by various medical therapy of hypertriglyceridemia varies according to the level of triglycerides found in the body. Moderate increase i.e >500 can be treated by statins while severe increase that is >1000 need to be treated by using a fibrate as the primary treatment.<ref name="pmid27710158">{{cite journal| author=Kushner PA, Cobble ME| title=Hypertriglyceridemia: the importance of identifying patients at risk. | journal=Postgrad Med | year= 2016 | volume= | issue= | pages= | pmid=27710158 | doi=10.1080/00325481.2016.1243005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27710158 }} </ref> | ||
==Surgery== | ==Surgery== | ||
==Prevention== | ==Prevention== | ||
Revision as of 16:49, 3 November 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2]
Overview
Primary hypertriglyceridemia i.e type 4 hyper lipidemia is due to high concentration of triglycerides in the blood. It is also known as hypertriglyceridemia (or pure hypertriglyceridemia). According to the NCEP-ATPIII definition of high triglycerides (>200 mg/dl), prevalence is about 16% of adult population.[1] Elevated levels of triglycerides can be detrimental for the normal cardiac functioning.[2]
Historical Perspective
Classification
Pathophisiology
Causes
Differentiating Primary hypertriglyceridemia from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
A large number of people in the US (approximately one fourth of the total population) have a high level of triglycerides (>150mg/dl) that can predispose and lead to numerous complications[3] including
- Cardiovascular diseases
- Non Alcoholic Fatty Liver Disease (NAFLD)
- Pancreatitis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Finding
Imaging Findings
Biopsy
Medical Therapy
The mainstay of therapy for hypertriglyceridemia includes life style modifications to lower the triglyceride levels to below 150 mg/dl. This can be achieved by various medical therapy of hypertriglyceridemia varies according to the level of triglycerides found in the body. Moderate increase i.e >500 can be treated by statins while severe increase that is >1000 need to be treated by using a fibrate as the primary treatment.[3]
Surgery
Prevention
References
- ↑ Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 2002; 106; page 3240
- ↑ Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH; et al. (2012). "Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline". J Clin Endocrinol Metab. 97 (9): 2969–89. doi:10.1210/jc.2011-3213. PMC 3431581. PMID 22962670.
- ↑ 3.0 3.1 Kushner PA, Cobble ME (2016). "Hypertriglyceridemia: the importance of identifying patients at risk". Postgrad Med. doi:10.1080/00325481.2016.1243005. PMID 27710158.