Primary hyperaldosteronism laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
There is [[metabolic alkalosis]] (due to increased secretion of H+ ions by the kidney). The high [[pH]] of the blood makes [[calcium in biology|calcium]] less available to the tissues leading to [[hypocalcemia]]. | There is [[metabolic alkalosis]] (due to increased secretion of H+ ions by the kidney). The high [[pH]] of the blood makes [[calcium in biology|calcium]] less available to the tissues leading to [[hypocalcemia]]. | ||
Measuring [[aldosterone]] alone is not considered adequate to diagnose Conn's syndrome. Rather, both [[renin]] and aldosterone are measured, and the ''ratio'' is diagnostic.<ref>{{cite journal |author=Tiu S, Choi C, Shek C, Ng Y, Chan F, Ng C, Kong A |title=The use of aldosterone-renin ratio as a diagnostic test for primary hyperaldosteronism and its test characteristics under different conditions of blood sampling |journal=J Clin Endocrinol Metab |volume=90 |issue=1 |pages=72-8 |year=2005 |pmid=15483077}}</ref><ref>http://www.ubht.nhs.uk/pathology/ChemicalPathology/TestProtocols/16Renin.html</ref> | |||
Usually, renin levels are suppressed, leading to a very low renin-aldosterone ratio (<0.0005). This test is confounded by [[antihypertensive drug]]s, which have to be stopped up to 6 weeks. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:24, 20 September 2012
Template:Conn syndrome Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
There is metabolic alkalosis (due to increased secretion of H+ ions by the kidney). The high pH of the blood makes calcium less available to the tissues leading to hypocalcemia.
Measuring aldosterone alone is not considered adequate to diagnose Conn's syndrome. Rather, both renin and aldosterone are measured, and the ratio is diagnostic.[1][2]
Usually, renin levels are suppressed, leading to a very low renin-aldosterone ratio (<0.0005). This test is confounded by antihypertensive drugs, which have to be stopped up to 6 weeks.
References
- ↑ Tiu S, Choi C, Shek C, Ng Y, Chan F, Ng C, Kong A (2005). "The use of aldosterone-renin ratio as a diagnostic test for primary hyperaldosteronism and its test characteristics under different conditions of blood sampling". J Clin Endocrinol Metab. 90 (1): 72–8. PMID 15483077.
- ↑ http://www.ubht.nhs.uk/pathology/ChemicalPathology/TestProtocols/16Renin.html