Primary central nervous system lymphoma natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Natural History

  • Primary central nervous system lymphoma is usually a fast-growing (aggressive) lymphoma.[1]
  • Primary central nervous system lymphoma often recurs after treatment.
  • The clinical course is rapidly fatal; these patients usually present signs of elevated intracranial pressure, nausea, papilledema, vomiting, and neuropsychiatric symptoms.[2]

Complications

Prognosis

  • The prognosis of primary central nervous system lymphoma is generally poor.[1]
  • Poor prognostic factors for primary central nervous system lymphoma include:[1]
  • Elderly patient
  • Poor performance status of the individual
  • AIDS-related primary central nervous system lymphoma

References

  1. 1.0 1.1 1.2 Prognosis of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016
  2. Manenti, G.; Di Giuliano, F.; Bindi, A.; Liberto, V.; Funel, V.; Garaci, F. G.; Floris, R.; Simonetti, G. (2013). "A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/916348. ISSN 2090-6862.


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