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==Overview==The prevalence of primary biliary cirrhosis is approximately 19 to 402 cases per 100,000 individuals worldwide.<ref name="pmid11113084">{{cite journal| author=Kim WR, Lindor KD, Locke GR, Therneau TM, Homburger HA, Batts KP et al.| title=Epidemiology and natural history of primary biliary cirrhosis in a US community. | journal=Gastroenterology | year= 2000 | volume= 119 | issue= 6 | pages= 1631-6 | pmid=11113084 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11113084  }} </ref><ref name="pmid15300579">{{cite journal| author=Sood S, Gow PJ, Christie JM, Angus PW| title=Epidemiology of primary biliary cirrhosis in Victoria, Australia: high prevalence in migrant populations. | journal=Gastroenterology | year= 2004 | volume= 127 | issue= 2 | pages= 470-5 | pmid=15300579 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15300579  }} </ref>Primary biliary cirrhosis commonly affects individuals in their 40s or 50s.<ref name="pmid16177252">{{cite journal| author=Kaplan MM, Gershwin ME| title=Primary biliary cirrhosis. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 12 | pages= 1261-73 | pmid=16177252 | doi=10.1056/NEJMra043898 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16177252  }} </ref><ref name="pmid14598264">{{cite journal| author=Dahlan Y, Smith L, Simmonds D, Jewell LD, Wanless I, Heathcote EJ et al.| title=Pediatric-onset primary biliary cirrhosis. | journal=Gastroenterology | year= 2003 | volume= 125 | issue= 5 | pages= 1476-9 | pmid=14598264 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14598264  }} </ref>There is no racial predilection to primary biliary cirrhosis. Females are more commonly affected by primary biliary cirrhosis than males.<ref name="pmid18603021">{{cite journal| author=Lleo A, Battezzati PM, Selmi C, Gershwin ME, Podda M| title=Is autoimmunity a matter of sex? | journal=Autoimmun Rev | year= 2008 | volume= 7 | issue= 8 | pages= 626-30 | pmid=18603021 | doi=10.1016/j.autrev.2008.06.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18603021  }} </ref>The majority of primary biliary cirrhosis cases are reported in northern Europe and North America (particularly in Scandinavia, Great Britain, and the northern midwest regions of the United States).<ref name="pmid21529926">{{cite journal| author=Selmi C, Bowlus CL, Gershwin ME, Coppel RL| title=Primary biliary cirrhosis. | journal=Lancet | year= 2011 | volume= 377 | issue= 9777 | pages= 1600-9 | pmid=21529926 | doi=10.1016/S0140-6736(10)61965-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21529926  }} </ref>
==Overview==
 
The prevalence of primary biliary cirrhosis is approximately 19 to 402 cases per 100,000 individuals worldwide.<ref name="pmid11113084">{{cite journal| author=Kim WR, Lindor KD, Locke GR, Therneau TM, Homburger HA, Batts KP et al.| title=Epidemiology and natural history of primary biliary cirrhosis in a US community. | journal=Gastroenterology | year= 2000 | volume= 119 | issue= 6 | pages= 1631-6 | pmid=11113084 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11113084  }} </ref><ref name="pmid15300579">{{cite journal| author=Sood S, Gow PJ, Christie JM, Angus PW| title=Epidemiology of primary biliary cirrhosis in Victoria, Australia: high prevalence in migrant populations. | journal=Gastroenterology | year= 2004 | volume= 127 | issue= 2 | pages= 470-5 | pmid=15300579 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15300579  }} </ref>Primary biliary cirrhosis commonly affects individuals in their 40s or 50s.<ref name="pmid16177252">{{cite journal| author=Kaplan MM, Gershwin ME| title=Primary biliary cirrhosis. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 12 | pages= 1261-73 | pmid=16177252 | doi=10.1056/NEJMra043898 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16177252  }} </ref><ref name="pmid14598264">{{cite journal| author=Dahlan Y, Smith L, Simmonds D, Jewell LD, Wanless I, Heathcote EJ et al.| title=Pediatric-onset primary biliary cirrhosis. | journal=Gastroenterology | year= 2003 | volume= 125 | issue= 5 | pages= 1476-9 | pmid=14598264 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14598264  }} </ref>There is no racial predilection to primary biliary cirrhosis. Females are more commonly affected by primary biliary cirrhosis than males.<ref name="pmid18603021">{{cite journal| author=Lleo A, Battezzati PM, Selmi C, Gershwin ME, Podda M| title=Is autoimmunity a matter of sex? | journal=Autoimmun Rev | year= 2008 | volume= 7 | issue= 8 | pages= 626-30 | pmid=18603021 | doi=10.1016/j.autrev.2008.06.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18603021  }} </ref>The majority of primary biliary cirrhosis cases are reported in northern Europe and North America (particularly in Scandinavia, Great Britain, and the northern midwest regions of the United States).<ref name="pmid21529926">{{cite journal| author=Selmi C, Bowlus CL, Gershwin ME, Coppel RL| title=Primary biliary cirrhosis. | journal=Lancet | year= 2011 | volume= 377 | issue= 9777 | pages= 1600-9 | pmid=21529926 | doi=10.1016/S0140-6736(10)61965-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21529926  }} </ref>
 
 
==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Prevalence===
===Prevalence===

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]

Overview

The prevalence of primary biliary cirrhosis is approximately 19 to 402 cases per 100,000 individuals worldwide.[1][2]Primary biliary cirrhosis commonly affects individuals in their 40s or 50s.[3][4]There is no racial predilection to primary biliary cirrhosis. Females are more commonly affected by primary biliary cirrhosis than males.[5]The majority of primary biliary cirrhosis cases are reported in northern Europe and North America (particularly in Scandinavia, Great Britain, and the northern midwest regions of the United States).[6]

Epidemiology and Demographics

Prevalence

  • The prevalence of primary biliary cirrhosis is approximately 19 to 402 cases per 100,000 individuals worldwide.[1][2]

Age

  • Primary biliary cirrhosis commonly affects individuals in their 40s or 50s.[3][4]

Race

  • There is no racial predilection to primary biliary cirrhosis.

Gender

  • Females are more commonly affected by primary biliary cirrhosis than males.[5]

Region

  • The majority of primary biliary cirrhosis cases are reported in northern Europe and North America (particularly in Scandinavia, Great Britain, and the northern midwest regions of the United States).[6]

References

  1. 1.0 1.1 Kim WR, Lindor KD, Locke GR, Therneau TM, Homburger HA, Batts KP; et al. (2000). "Epidemiology and natural history of primary biliary cirrhosis in a US community". Gastroenterology. 119 (6): 1631–6. PMID 11113084.
  2. 2.0 2.1 Sood S, Gow PJ, Christie JM, Angus PW (2004). "Epidemiology of primary biliary cirrhosis in Victoria, Australia: high prevalence in migrant populations". Gastroenterology. 127 (2): 470–5. PMID 15300579.
  3. 3.0 3.1 Kaplan MM, Gershwin ME (2005). "Primary biliary cirrhosis". N Engl J Med. 353 (12): 1261–73. doi:10.1056/NEJMra043898. PMID 16177252.
  4. 4.0 4.1 Dahlan Y, Smith L, Simmonds D, Jewell LD, Wanless I, Heathcote EJ; et al. (2003). "Pediatric-onset primary biliary cirrhosis". Gastroenterology. 125 (5): 1476–9. PMID 14598264.
  5. 5.0 5.1 Lleo A, Battezzati PM, Selmi C, Gershwin ME, Podda M (2008). "Is autoimmunity a matter of sex?". Autoimmun Rev. 7 (8): 626–30. doi:10.1016/j.autrev.2008.06.009. PMID 18603021.
  6. 6.0 6.1 Selmi C, Bowlus CL, Gershwin ME, Coppel RL (2011). "Primary biliary cirrhosis". Lancet. 377 (9777): 1600–9. doi:10.1016/S0140-6736(10)61965-4. PMID 21529926.

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