Povidone-iodine: Difference between revisions

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{{DrugProjectFormSinglePage
{{DrugProjectFormSinglePage
|authorTag=<!--Overview-->
|authorTag={{Ammu}}
|genericName=povidone iodine
|aOrAn=a
|aOrAn=a
|hasBlackBoxWarning=Yes
|drugClass=antiseptic
|adverseReactions=<!--Black Box Warning-->
|indicationType=prophylaxis
|indication=surgical handrub, aseptic handwash
|adverseReactions=contact dermatitis and other dermatological manifestations
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
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<!--FDA-Labeled Indications and Dosage (Adult)-->
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====
|fdaLIADAdult=* Surgical hand scrub: significantly reduces the number of micro-organisms on the hands and forearms prior to surgery or patient care
 
* Antiseptic hand wash: for handwashing to help reduce bacteria on the skin.
* Dosing Information
=====Admnistration=====
 
* Remove jewelry
:* Dosage
* Clean nails with an orangewood stick
 
* Wet hands and forearms with water and apply 5 ml of the product
=====Condition2=====
wash/scrub hands and forearms for 5 minutes paying particular attention to nails, cuticles, and interdigital spaces
 
rinse thoroughly with water
* Dosing Information
* Wet hands and forearms with water and apply 5 ml of the product
 
wash hands and forearms for 5 minutes
:* Dosage
* Rinse thoroughly with water
 
=====Antiseptic Handwash=====
=====Condition3=====
* Wet hands and forearms
 
* Dispense a palmful of product to hands
* Dosing Information
* Scrub hands and forearms for 20 seconds
 
* Rinse thoroughly and dry
:* Dosage
|offLabelAdultGuideSupport=
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
<!--Guideline-Supported Use (Adult)-->
|offLabelAdultGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.


<!--Non–Guideline-Supported Use (Adult)-->
<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport======Condition1=====
|offLabelAdultNoGuideSupport=
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====


There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
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<!--FDA-Labeled Indications and Dosage (Pediatric)-->
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed======Condition1=====
|fdaLIADPed=
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====


There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
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<!--Guideline-Supported Use (Pediatric)-->
<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport======Condition1=====
|offLabelPedGuideSupport=
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.


<!--Non–Guideline-Supported Use (Pediatric)-->
<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport======Condition1=====
|offLabelPedNoGuideSupport=
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.


<!--Contraindications-->
<!--Contraindications-->
|contraindications=* Condition1
|warnings=* For external use only
 
* Do not use in eyes
<!--Warnings-->
* When using this product
|warnings=* Description
if in eyes, rinse promptly and thoroughly with water
 
discontinue use if irritation and redness develop
====Precautions====
* Stop use and ask a doctor if skin irritation and redness occurs for more than 72 hours.
 
* Keep out of reach of children.  If swallowed, get medical help or contact Poison Control Center right away.
* Description
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.


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<!--Postmarketing Experience-->
<!--Postmarketing Experience-->
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
|postmarketing=Contact dermatitis
 
|FDAPregCat=C
=====Body as a Whole=====
 
 
 
=====Cardiovascular=====
 
 
 
=====Digestive=====
 
 
 
=====Endocrine=====
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
=====Metabolic and Nutritional=====
 
 
 
=====Musculoskeletal=====
 
 
 
=====Neurologic=====
 
 
 
=====Respiratory=====
 
 
 
=====Skin and Hypersensitivy Reactions=====
 
 
 
=====Special Senses=====
 
 
 
=====Urogenital=====
 
 
 
=====Miscellaneous=====
 
 
 
<!--Drug Interactions-->
|drugInteractions=* Drug
:* Description
 
<!--Use in Specific Populations-->
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
Line 264: Line 149:


<!--Administration and Monitoring-->
<!--Administration and Monitoring-->
|administration=* Oral
|administration=* Topical
 
* Intravenous
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


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<!--Overdosage-->
<!--Overdosage-->
|overdose====Acute Overdose===
|drugBox={{Drugbox2
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 457790761
| IUPAC_name = 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine.
| image = Povidon-Iod.png
| width = 350


====Signs and Symptoms====
<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|povidone-iodine}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US = OTC
| legal_status = 
| routes_of_administration = topical


* Description
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion =


====Management====
<!--Identifiers-->
| CASNo_Ref = {{cascite}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 25655-41-8
| ATC_prefix = D08
| ATC_suffix = AG02
| ATC_supplemental = {{ATC|D09|AA09}} (dressing) {{ATC|D11|AC06}} {{ATC|G01|AX11}} {{ATC|R02|AA15}} {{ATC|S01|AX18}} {{ATCvet|G51|AD01}}
| PubChem = 410087
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = 
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 85H0HZU99M
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1201724
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = NA


* Description
<!--Chemical data-->
 
| chemical_formula = (C<sub>6</sub>H<sub>9</sub>NO)<sub>n</sub>·xI
===Chronic Overdose===
| molecular_weight = variable
 
}}
There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.
 
<!--Pharmacology-->


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|drugBox=<!--Mechanism of Action-->
|mechAction=*
 
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: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
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<!--Brand Names-->
<!--Brand Names-->
|brandNames=* ®<ref>{{Cite web | title = | url = }}</ref>
|brandNames=* ECOLAB®<ref>{{Cite web | title = ECOLAB - povidone-iodine solution  | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48acaae5-8c9c-451c-ac73-8307f4ef928e }}</ref>


<!--Look-Alike Drug Names-->
<!--Look-Alike Drug Names-->
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<!--Drug Shortage Status-->
<!--Drug Shortage Status-->
|drugShortage=
|drugShortage=
}}
{{PillImage
|fileName=No image.jpg
}}
}}
{{LabelImage
{{LabelImage
|fileName={{PAGENAME}}11.png
|fileName=Iodine.jpg
}}
}}
{{LabelImage
{{LabelImage
|fileName={{PAGENAME}}11.png
|fileName=DailyMed - ECOLAB - povidone-iodine solution  .png
}}
}}
<!--Pill Image-->
<!--Pill Image-->

Revision as of 22:50, 7 January 2015

Povidone-iodine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Povidone-iodine is a antiseptic that is FDA approved for the prophylaxis of surgical handrub, aseptic handwash. Common adverse reactions include contact dermatitis and other dermatological manifestations.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Surgical hand scrub: significantly reduces the number of micro-organisms on the hands and forearms prior to surgery or patient care
  • Antiseptic hand wash: for handwashing to help reduce bacteria on the skin.
Admnistration
  • Remove jewelry
  • Clean nails with an orangewood stick
  • Wet hands and forearms with water and apply 5 ml of the product

wash/scrub hands and forearms for 5 minutes paying particular attention to nails, cuticles, and interdigital spaces rinse thoroughly with water

  • Wet hands and forearms with water and apply 5 ml of the product

wash hands and forearms for 5 minutes

  • Rinse thoroughly with water
Antiseptic Handwash
  • Wet hands and forearms
  • Dispense a palmful of product to hands
  • Scrub hands and forearms for 20 seconds
  • Rinse thoroughly and dry

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Povidone-iodine in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Povidone-iodine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Povidone-iodine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Povidone-iodine in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Povidone-iodine in pediatric patients.

Contraindications

There is limited information regarding Povidone-iodine Contraindications in the drug label.

Warnings

  • For external use only
  • Do not use in eyes
  • When using this product

if in eyes, rinse promptly and thoroughly with water discontinue use if irritation and redness develop

  • Stop use and ask a doctor if skin irritation and redness occurs for more than 72 hours.
  • Keep out of reach of children. If swallowed, get medical help or contact Poison Control Center right away.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Povidone-iodine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

Contact dermatitis

Drug Interactions

There is limited information regarding Povidone-iodine Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): C

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Povidone-iodine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Povidone-iodine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Povidone-iodine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Povidone-iodine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Povidone-iodine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Povidone-iodine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Povidone-iodine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Povidone-iodine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Povidone-iodine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Povidone-iodine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Povidone-iodine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Topical

Monitoring

There is limited information regarding Monitoring of Povidone-iodine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Povidone-iodine in the drug label.

Overdosage

There is limited information regarding Povidone-iodine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

Template:Px
Povidone-iodine
Systematic (IUPAC) name
2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine.
Identifiers
CAS number 25655-41-8
ATC code D08AG02 D09AA09 (WHO) (dressing) D11AC06 (WHO) G01AX11 (WHO) R02AA15 (WHO) S01AX18 (WHO) Template:ATCvet
PubChem 410087
Chemical data
Formula (C6H9NO)n·xI
Mol. mass variable
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

OTC(US)

Routes topical

Mechanism of Action

There is limited information regarding Povidone-iodine Mechanism of Action in the drug label.

Structure

File:Povidone-iodine01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Povidone-iodine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Povidone-iodine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Povidone-iodine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Povidone-iodine in the drug label.

How Supplied

Storage

There is limited information regarding Povidone-iodine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Povidone-iodine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Povidone-iodine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Povidone-iodine in the drug label.

Precautions with Alcohol

  • Alcohol-Povidone-iodine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ "ECOLAB - povidone-iodine solution".
  2. ↑ "http://www.ismp.org". External link in |title= (help)

{{#subobject: 

 |Label Page=Povidone-iodine
 |Label Name=Iodine.jpg

}}

{{#subobject: 

 |Label Page=Povidone-iodine
 |Label Name=DailyMed - ECOLAB - povidone-iodine solution  .png

}}

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