Potassium chloride: Difference between revisions

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<!--FDA-Labeled Indications and Dosage (Adult)-->
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====
|fdaLIADAdult======Hypokalemia with or without metabolic alkalosis=====
 
*For therapeutic use in patients with hypokalemia with or without metabolic alkalosis; in digitalis intoxication and in patients with hypokalemic familial periodic paralysis.


* Dosing Information
* Dosing Information


:* Dosage
:*Dosage must be adjusted to the individual needs of each patient but is typically in the range of 40-100 mEq per day or more for the treatment of potassium depletion.
 
=====Condition2=====


* Dosing Information
:*The usual adult dose is 20-100 mEq of potassium per day (one KLOR-CON® 20 mEq packet 1 to 5 times daily after meals or one KLOR-CON® /25 25 mEq packet 1 to 4 times daily after meals).


:* Dosage
:*The contents of each KLOR-CON® packet should be dissolved in at least 4 ounces of cold water or other beverage. The contents of each KLOR-CON® /25 packet should be dissolved in at least 5 ounces of cold water or other beverage. These preparations, like other potassium supplements, must be properly diluted to avoid the possibility of gastrointestinal irritation.


=====Condition3=====
=====Hypokalemia; Prophylaxis=====


* Dosing Information
* Dosing Information


:* Dosage
:*Dosage must be adjusted to the individual needs of each patient but is typically in the range of 20 mEq per day for the prevention of hypokalemia.


=====Condition4=====
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases supplementation with potassium salts may be indicated.
 
* Dosing Information
 
:* Dosage


<!--Off-Label Use and Dosage (Adult)-->
<!--Off-Label Use and Dosage (Adult)-->
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<!--Drug box 2-->
<!--Drug box 2-->
|drugBox=<!--Mechanism of Action-->
|drugBox=<!--Mechanism of Action-->
|mechAction=*
|mechAction=Potassium ion is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes, including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal, and smooth muscle and the maintenance of normal renal function.


<!--Structure-->
Potassium depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate of potassium intake. Such depletion usually develops slowly as a consequence of prolonged therapy with oral diuretics, primary or secondary hyperaldosteronism, diabetic ketoacidosis, severe diarrhea, or inadequate replacement of potassium in patients on prolonged parenteral nutrition. Potassium depletion due to these causes is usually accompanied by a concomitant deficiency of chloride and is manifested by hypokalemia and metabolic alkalosis. Potassium depletion may produce weakness, fatigue, disturbances of cardiac rhythm (primarily ectopic beats), prominent U-waves in the electro-cardiogram, and in advanced cases flaccid paralysis and/or impaired ability to concentrate urine.
|structure=*


: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
Potassium depletion associated with metabolic alkalosis is managed by correcting the fundamental causes of the deficiency whenever possible and administering supplemental potassium chloride, in the form of high potassium food or potassium chloride solution or tablets.


<!--Pharmacodynamics-->
In rare circumstances (e.g., patients with renal tubular acidosis) potassium depletion may be associated with metabolic acidosis and hyperchloremia. In such patients potassium replacement should be accomplished with potassium salts other than the chloride, such as potassium bicarbonate, potassium citrate or potassium acetate.
|structure=Fruit-flavored KLOR-CON® and KLOR-CON®/25 Powder (Potassium Chloride for Oral Solution, USP) are oral potassium supplements offered as powder for reconstitution in individual packets. Each packet of KLOR-CON® powder contains potassium 20 mEq and chloride 20 mEq provided by potassium chloride 1.5 g. Each packet of KLOR-CON®/25 powder contains potassium 25 mEq and chloride 25 mEq provided by potassium chloride 1.875 g. KLOR-CON® and KLOR-CON®/25 are sugar-free. Inactive ingredients: FD&C Yellow No. 6, malic acid, neotame, silicon dioxide, and natural and/or artificial flavors.
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.



Revision as of 21:03, 19 October 2014

Potassium chloride
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Deepika Beereddy, MBBS [2]

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Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Potassium chloride is a {{{drugClass}}} that is FDA approved for the treatment of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Hypokalemia with or without metabolic alkalosis
  • For therapeutic use in patients with hypokalemia with or without metabolic alkalosis; in digitalis intoxication and in patients with hypokalemic familial periodic paralysis.
  • Dosing Information
  • Dosage must be adjusted to the individual needs of each patient but is typically in the range of 40-100 mEq per day or more for the treatment of potassium depletion.
  • The usual adult dose is 20-100 mEq of potassium per day (one KLOR-CON® 20 mEq packet 1 to 5 times daily after meals or one KLOR-CON® /25 25 mEq packet 1 to 4 times daily after meals).
  • The contents of each KLOR-CON® packet should be dissolved in at least 4 ounces of cold water or other beverage. The contents of each KLOR-CON® /25 packet should be dissolved in at least 5 ounces of cold water or other beverage. These preparations, like other potassium supplements, must be properly diluted to avoid the possibility of gastrointestinal irritation.
Hypokalemia; Prophylaxis
  • Dosing Information
  • Dosage must be adjusted to the individual needs of each patient but is typically in the range of 20 mEq per day for the prevention of hypokalemia.
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases supplementation with potassium salts may be indicated.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Potassium chloride in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Potassium chloride in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Potassium chloride in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Potassium chloride in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Potassium chloride in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Potassium chloride in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Potassium chloride in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Potassium chloride in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Potassium chloride during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Potassium chloride with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Potassium chloride with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Potassium chloride with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Potassium chloride with respect to specific gender populations.

Race

There is no FDA guidance on the use of Potassium chloride with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Potassium chloride in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Potassium chloride in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Potassium chloride in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Potassium chloride in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Potassium chloride in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Potassium chloride in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Potassium chloride in the drug label.

Pharmacology

There is limited information regarding Potassium chloride Pharmacology in the drug label.

Mechanism of Action

Potassium ion is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes, including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal, and smooth muscle and the maintenance of normal renal function.

Potassium depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate of potassium intake. Such depletion usually develops slowly as a consequence of prolonged therapy with oral diuretics, primary or secondary hyperaldosteronism, diabetic ketoacidosis, severe diarrhea, or inadequate replacement of potassium in patients on prolonged parenteral nutrition. Potassium depletion due to these causes is usually accompanied by a concomitant deficiency of chloride and is manifested by hypokalemia and metabolic alkalosis. Potassium depletion may produce weakness, fatigue, disturbances of cardiac rhythm (primarily ectopic beats), prominent U-waves in the electro-cardiogram, and in advanced cases flaccid paralysis and/or impaired ability to concentrate urine.

Potassium depletion associated with metabolic alkalosis is managed by correcting the fundamental causes of the deficiency whenever possible and administering supplemental potassium chloride, in the form of high potassium food or potassium chloride solution or tablets.

In rare circumstances (e.g., patients with renal tubular acidosis) potassium depletion may be associated with metabolic acidosis and hyperchloremia. In such patients potassium replacement should be accomplished with potassium salts other than the chloride, such as potassium bicarbonate, potassium citrate or potassium acetate.

Structure

Fruit-flavored KLOR-CON® and KLOR-CON®/25 Powder (Potassium Chloride for Oral Solution, USP) are oral potassium supplements offered as powder for reconstitution in individual packets. Each packet of KLOR-CON® powder contains potassium 20 mEq and chloride 20 mEq provided by potassium chloride 1.5 g. Each packet of KLOR-CON®/25 powder contains potassium 25 mEq and chloride 25 mEq provided by potassium chloride 1.875 g. KLOR-CON® and KLOR-CON®/25 are sugar-free. Inactive ingredients: FD&C Yellow No. 6, malic acid, neotame, silicon dioxide, and natural and/or artificial flavors.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Potassium chloride in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Potassium chloride in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Potassium chloride in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Potassium chloride in the drug label.

How Supplied

Storage

There is limited information regarding Potassium chloride Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

{{#ask: Label Page::Potassium chloride |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Potassium chloride in the drug label.

Precautions with Alcohol

  • Alcohol-Potassium chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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  2. "http://www.ismp.org". External link in |title= (help)

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