Post-polio syndrome overview: Difference between revisions

Jump to navigation Jump to search
No edit summary
m (Changes made per Mahshid's request)
 
Line 43: Line 43:
[[Category:Poliomyelitis]]
[[Category:Poliomyelitis]]
[[Category:Motor neuron disease]]
[[Category:Motor neuron disease]]
[[Category:Infectious disease]]
 


{{WH}}
{{WH}}
{{WS}}
{{WS}}

Latest revision as of 18:46, 18 September 2017

Post-polio syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Post-polio syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Post-polio syndrome overview On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Post-polio syndrome overview

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Post-polio syndrome overview

CDC on Post-polio syndrome overview

Post-polio syndrome overview in the news

Blogs on Post-polio syndrome overview

Directions to Hospitals Treating Post-polio syndrome

Risk calculators and risk factors for Post-polio syndrome overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Post-polio syndrome (PPS) is a condition that affects survivors of poliomyelitis, a viral infection of the nervous system, after recovery from an initial paralytic attack of the virus.

Pathophysiology

The precise mechanism that causes post-polio syndrome is unknown.

Differentiating Post-polio Syndrome from other Diseases

PPS has been confused with amyotrophic lateral sclerosis (ALS), which progressively weakens muscles. PPS patients do not have an elevated risk of ALS.

PPS shares many features in common with myalgic encephalomyelitis, a form of chronic fatigue syndrome that is apparently caused by viral infections, but unlike those disorders it tends to be progressive, and can cause tangible loss of muscle strength.

Natural History, Complications and Prognosis

In general, PPS is not life-threatening. The major exception are patients left with severe residual respiratory difficulties, who may experience new severe respiratory impairment.There have been no sufficient longitudinal studies on the prognosis of post-polio syndrome; however, speculations have been made by several physicians based on experience. Fatigue and mobility usually return to normal over a long period of time. The prognosis also differs depending upon different causes and factors affecting the individual. An overall mortality rate of 25% exists due to possible respiratory paralysis of persons with post-polio syndrome; otherwise, post-polio syndrome is usually non-lethal.[1]

Diagnosis

Typically the symptoms appear 20-40 years after the original infection, at an age of 35 to 60. Symptoms include new or increased muscular weakness, pain in the muscles, and fatigue.[2]

Diagnosis of post-polio syndrome can be difficult, since the symptoms are hard to separate from the original symptoms of polio and from the normal infirmities of aging. There is no laboratory test for post-polio syndrome, nor is there any other specific diagnostic, and diagnosis is usually a "diagnosis of exclusion" whereby other possible causes of the symptoms are eliminated.[3]

Physical Examination

PPS may be difficult to diagnose in some because it is hard to determine what component of a neuromuscular deficit is old and what is new: Neurological examination aided by other laboratory studies can help to exclude all other possible diagnoses. Objective assessment of muscle strength in PPS patients may not be easy. Changes in muscle strength are determined in specific muscle groups sing various muscle scales which quantify strength, such as the Medical Research Council (MRC) scale.

Laboratory Findings

Muscle biopsies and spinal fluid analysis may also be used in establishing a PPS diagnosis.

MRI

Magnetic resonance imaging (MRI) and neuroimaging may also be used in establishing a PPS diagnosis.

Other Diagnostic Studies

Electrophysiological studies may also be used in establishing a PPS diagnosis.

Treatment

Treatment generally is limited to supportive measures, primarily leg braces and energy-saving devices such as powered wheelchairs, plus pain relievers, sleep aids, etc.

References

  1. Lindsay, Kenneth W (1991). Neurology and Neurosurgery Illustrated. United States: Churchill Livingstone. pp. 489–490. ISBN 0-443-04345-0. Unknown parameter |coauthors= ignored (help)
  2. Trojan D, Cashman N (2005). "Post-poliomyelitis syndrome". Muscle Nerve. 31 (1): 6–19. PMID 15599928.
  3. Silver JK, Gawne AC (2003). Postpolio Syndrome. Philadelphia: Hanley & Belfus. ISBN 1560536063.


Template:WH Template:WS