Polyethylene glycol: Difference between revisions
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|genericName=Polyethylene glycol | |genericName=Polyethylene glycol | ||
|aOrAn=a | |aOrAn=a | ||
|drugClass=Laxative | |drugClass=[[Laxative]] | ||
|indicationType=treatment | |indicationType=treatment | ||
|indication=constipation | |indication=[[constipation]] | ||
|adverseReactions=Diarrhea, Flatulence, Nausea, Stomach cramps | |adverseReactions=[[Diarrhea]], [[Flatulence]], [[Nausea]], [[Stomach cramps]] | ||
<!--Black Box Warning--> | <!--Black Box Warning--> | ||
| Line 13: | Line 13: | ||
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i> | |blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i> | ||
<!--Adult Indications and Dosage--> | <!--Adult Indications and Dosage--> | ||
| Line 19: | Line 18: | ||
<!--FDA-Labeled Indications and Dosage (Adult)--> | <!--FDA-Labeled Indications and Dosage (Adult)--> | ||
|fdaLIADAdult=====Indications==== | |fdaLIADAdult=====Indications==== | ||
relieves occasional constipation (irregularity) | * relieves occasional [[constipation]] (irregularity) | ||
generally produces a bowel movement in 1 to 3 days | * generally produces a bowel movement in 1 to 3 days | ||
====Directions==== | ====Directions==== | ||
do not take more than directed unless advised by your doctor | * do not take more than directed unless advised by your doctor | ||
the enclosed scoop is a measuring device designed to contain 17 grams of powder when filled to the top (level scoop) | * the enclosed scoop is a measuring device designed to contain 17 grams of powder when filled to the top (level scoop) | ||
adults and children 17 years of age and older: | * adults and children 17 years of age and older: | ||
fill scoop completely with product to obtain the correct dose (17 g). Level scoop with knife or flat object. | * fill scoop completely with product to obtain the correct dose (17 g). Level scoop with knife or flat object. | ||
stir and dissolve in any 4 to 8 ounces of beverage (cold, hot or room temperature) then drink | * stir and dissolve in any 4 to 8 ounces of beverage (cold, hot or room temperature) then drink | ||
use once a day | * use once a day | ||
use no more than 7 days | * use no more than 7 days | ||
children 16 years of age or under: ask a doctor | * children 16 years of age or under: ask a doctor | ||
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients. | |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients. | ||
| Line 46: | Line 45: | ||
<!--Contraindications--> | <!--Contraindications--> | ||
|contraindications= | |contraindications= | ||
<!--Warnings--> | <!--Warnings--> | ||
|warnings=* Allergy alert: Do not use if you are allergic to polyethylene glycol | |warnings=* Allergy alert: Do not use if you are allergic to polyethylene glycol | ||
Do not use | * Do not use | ||
if you have kidney disease, except under the advice and supervision of a doctor | :* if you have kidney disease, except under the advice and supervision of a doctor | ||
Ask a doctor before use if you have | * Ask a doctor before use if you have | ||
nausea, vomiting or abdominal pain | :* [[nausea]], [[vomiting]] or [[abdominal pain]] | ||
a sudden change in bowel habits that lasts over 2 weeks | :* a sudden change in bowel habits that lasts over 2 weeks | ||
irritable bowel syndrome | :* irritable bowel syndrome | ||
Ask a doctor or pharmacist before use if you are | * Ask a doctor or pharmacist before use if you are | ||
taking a prescription drug | :* taking a prescription drug | ||
When using this product | * When using this product | ||
you may have loose, watery, more frequent stools | :* you may have loose, watery, more frequent stools | ||
Stop use and ask a doctor if | * Stop use and ask a doctor if | ||
you have rectal bleeding or your nausea, bloating, cramping or abdominal pain gets worse. These may be signs of a serious condition. | :* you have rectal bleeding or your [[nausea]], [[bloating]], [[cramping]] or [[abdominal pain]] gets worse. These may be signs of a serious condition. | ||
you get diarrhea | :* you get [[diarrhea]] | ||
you need to use a laxative for longer than 1 week | :* you need to use a [[laxative]] for longer than 1 week | ||
If pregnant or breast-feeding, | * If pregnant or breast-feeding, | ||
ask a health professional before use. | :* ask a health professional before use. | ||
Keep out of reach of children. | * Keep out of reach of children. | ||
In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) | :* In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) | ||
<!--Adverse Reactions--> | <!--Adverse Reactions--> | ||
| Line 78: | Line 77: | ||
<!--Clinical Trials Experience--> | <!--Clinical Trials Experience--> | ||
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label. | |clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label. | ||
<!--Postmarketing Experience--> | <!--Postmarketing Experience--> | ||
|postmarketing=Diarrhea, Flatulence, Nausea, Stomach cramps | |postmarketing=* [[Diarrhea]], [[Flatulence]], [[Nausea]], [[Stomach cramps]] | ||
|drugInteractions= | |drugInteractions= | ||
<!--Use in Specific Populations--> | <!--Use in Specific Populations--> | ||
| Line 166: | Line 102: | ||
<!--Administration and Monitoring--> | <!--Administration and Monitoring--> | ||
|administration=* Oral | |administration=* [[Oral]] | ||
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label. | |monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label. | ||
| Line 237: | Line 173: | ||
<!--How Supplied--> | <!--How Supplied--> | ||
|howSupplied=* | |howSupplied=* | ||
|storage=store at 20°-25°C (68°-77°F) | |storage=* store at 20°-25°C (68°-77°F) | ||
tamper-evident: do not use if printed foil seal under cap is missing, open or broken | * tamper-evident: do not use if printed foil seal under cap is missing, open or broken | ||
|packLabel=PRINCIPAL DISPLAY PANEL | |packLabel=====PRINCIPAL DISPLAY PANEL==== | ||
: [[File:Poly PDP.png|thumb|none|600px|This image is provided by the National Library of Medicine.]] | : [[File:Poly PDP.png|thumb|none|600px|This image is provided by the National Library of Medicine.]] | ||
====Ingredients and Appearance==== | |||
: [[File:Poly I n A.png|thumb|none|600px|This image is provided by the National Library of Medicine.]] | : [[File:Poly I n A.png|thumb|none|600px|This image is provided by the National Library of Medicine.]] | ||
| Line 260: | Line 198: | ||
|drugShortage= | |drugShortage= | ||
}} | }} | ||
Latest revision as of 13:53, 27 April 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]
Disclaimer
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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.
Overview
Polyethylene glycol is a Laxative that is FDA approved for the treatment of constipation. Common adverse reactions include Diarrhea, Flatulence, Nausea, Stomach cramps.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Indications
- relieves occasional constipation (irregularity)
- generally produces a bowel movement in 1 to 3 days
Directions
- do not take more than directed unless advised by your doctor
- the enclosed scoop is a measuring device designed to contain 17 grams of powder when filled to the top (level scoop)
- adults and children 17 years of age and older:
- fill scoop completely with product to obtain the correct dose (17 g). Level scoop with knife or flat object.
- stir and dissolve in any 4 to 8 ounces of beverage (cold, hot or room temperature) then drink
- use once a day
- use no more than 7 days
- children 16 years of age or under: ask a doctor
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Polyethylene glycol in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Polyethylene glycol in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
safety and effectiveness not established in children
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Polyethylene glycol in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Polyethylene glycol in pediatric patients.
Contraindications
There is limited information regarding Polyethylene glycol Contraindications in the drug label.
Warnings
- Allergy alert: Do not use if you are allergic to polyethylene glycol
- Do not use
- if you have kidney disease, except under the advice and supervision of a doctor
- Ask a doctor before use if you have
- nausea, vomiting or abdominal pain
- a sudden change in bowel habits that lasts over 2 weeks
- irritable bowel syndrome
- Ask a doctor or pharmacist before use if you are
- taking a prescription drug
- When using this product
- you may have loose, watery, more frequent stools
- Stop use and ask a doctor if
- If pregnant or breast-feeding,
- ask a health professional before use.
- Keep out of reach of children.
- In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Polyethylene glycol in the drug label.
Postmarketing Experience
Drug Interactions
There is limited information regarding Polyethylene glycol Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
- If pregnant or breast-feeding,
ask a health professional before use.
Pregnancy Category (AUS):
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Polyethylene glycol in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Polyethylene glycol during labor and delivery.
Nursing Mothers
If pregnant or breast-feeding, ask a health professional before use.
Pediatric Use
safety and effectiveness not established in children
Geriatic Use
There is no FDA guidance on the use of Polyethylene glycol with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Polyethylene glycol with respect to specific gender populations.
Race
There is no FDA guidance on the use of Polyethylene glycol with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Polyethylene glycol in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Polyethylene glycol in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Polyethylene glycol in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Polyethylene glycol in patients who are immunocompromised.
Administration and Monitoring
Administration
Monitoring
There is limited information regarding Monitoring of Polyethylene glycol in the drug label.
IV Compatibility
There is limited information regarding IV Compatibility of Polyethylene glycol in the drug label.
Overdosage
In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
Pharmacology
Template:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox E numberTemplate:Chembox FlashPtTemplate:Chembox Supplement| Template:Chembox header2 | Polyethylene glycol | |
|---|---|
| Identifiers | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). |
| UNII | |
| Properties | |
| C2nH4n+2On+1 | |
| Molar mass | variable |
| Hazards | |
| Template:Chembox header2 | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Mechanism of Action
Structure
- ACTIVE INGREDIENT (IN EACH DOSE)
Polyethylene Glycol 3350, 17 g (in each level scoop)
Pharmacodynamics
There is limited information regarding Pharmacodynamics of Polyethylene glycol in the drug label.
Pharmacokinetics
There is limited information regarding Pharmacokinetics of Polyethylene glycol in the drug label.
Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Polyethylene glycol in the drug label.
Clinical Studies
There is limited information regarding Clinical Studies of Polyethylene glycol in the drug label.
How Supplied
Storage
- store at 20°-25°C (68°-77°F)
- tamper-evident: do not use if printed foil seal under cap is missing, open or broken
Images
Drug Images
{{#ask: Page Name::Polyethylene glycol |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}
Package and Label Display Panel
PRINCIPAL DISPLAY PANEL
This image is provided by the National Library of Medicine.
Ingredients and Appearance
This image is provided by the National Library of Medicine.
{{#ask: Label Page::Polyethylene glycol |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}
Patient Counseling Information
QUESTIONS OR COMMENTS? 1-800-719-9260
Precautions with Alcohol
- Alcohol-Polyethylene glycol interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
- CLEAR LAX®[1]
Look-Alike Drug Names
There is no information regarding look alike drug names
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
- Pages with script errors
- Pages with non-numeric formatnum arguments
- Chemicals without a PubChem CID
- Articles without InChI source
- Articles without KEGG source
- Chemical articles with unknown parameter in Chembox
- Articles with changed EBI identifier
- ECHA InfoCard ID from Wikidata
- Articles with changed FDA identifier
- Drug