Polyethylene glycol: Difference between revisions

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{{Chembox new
{{DrugProjectFormSinglePage
| ImageFile = Polyethylene glycol chemical structure.png
|authorTag={{RB}}
| ImageSize =  
|OTC=Yes
| IUPACName =  
|genericName=Polyethylene glycol
| OtherNames =  
|aOrAn=a
| Section1 = {{Chembox Identifiers
|drugClass=[[Laxative]]
|   CASNo = 25322-68-3
|indicationType=treatment
|   PubChem =  
|indication=[[constipation]]
|   SMILES =  
|adverseReactions=[[Diarrhea]], [[Flatulence]], [[Nausea]], [[Stomach cramps]]
  }}
 
| Section2 = {{Chembox Properties
<!--Black Box Warning-->
|   Formula = C<sub>2n</sub>H<sub>4n+2</sub>O<sub>n+1</sub>
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|   MolarMass = depends on ''n''
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
|  Appearance =  
 
|   Density =  
 
|   MeltingPt =  
<!--Adult Indications and Dosage-->
|   BoilingPt =  
 
|   Solubility =  
<!--FDA-Labeled Indications and Dosage (Adult)-->
  }}
|fdaLIADAdult=====Indications====
| Section3 = {{Chembox Hazards
* relieves occasional [[constipation]] (irregularity)
|   MainHazards =  
* generally produces a bowel movement in 1 to 3 days
|   FlashPt = 182 - 287 °C
 
|  Autoignition =
====Directions====
  }}
* do not take more than directed unless advised by your doctor
}}
* the enclosed scoop is a measuring device designed to contain 17 grams of powder when filled to the top (level scoop)
__NOTOC__
* adults and children 17 years of age and older:
{{SI}}
* fill scoop completely with product to obtain the correct dose (17 g). Level scoop with knife or flat object.
{{CMG}}
* stir and dissolve in any 4 to 8 ounces of beverage (cold, hot or room temperature) then drink
* use once a day
* use no more than 7 days
* children 16 years of age or under: ask a doctor
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed=safety and effectiveness not established in children
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Contraindications-->
|contraindications=
 
<!--Warnings-->
|warnings=* Allergy alert: Do not use if you are allergic to polyethylene glycol
 
* Do not use
:* if you have kidney disease, except under the advice and supervision of a doctor
 
* Ask a doctor before use if you have
:* [[nausea]], [[vomiting]] or [[abdominal pain]]
:* a sudden change in bowel habits that lasts over 2 weeks
:* irritable bowel syndrome
* Ask a doctor or pharmacist before use if you are
:* taking a prescription drug
 
* When using this product
:* you may have loose, watery, more frequent stools
 
* Stop use and ask a doctor if
:* you have rectal bleeding or your [[nausea]], [[bloating]], [[cramping]] or [[abdominal pain]] gets worse. These may be signs of a serious condition.
:* you get [[diarrhea]]
:* you need to use a [[laxative]] for longer than 1 week
* If pregnant or breast-feeding,
:* ask a health professional before use.
 
* Keep out of reach of children.
:* In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.


==Overview==
'''Polyethylene glycol''' (PEG) and '''polyethylene oxide''' (PEO) are [[polymer]]s composed of repeating subunits of identical structure, called [[monomers]], and are the most commercially important [[Ether|polyethers]].  Poly ([[ethylene glycol]]) or poly ([[ethylene oxide]]) refers to an [[oligomer]] or polymer of ethylene oxide.  The two names are chemically synonymous, but historically PEG has tended to refer to shorter polymers, PEO to longer.<ref>For example, in the online catalog[http://www.scientificpolymer.com/utils/search.asp] of Scientific Polymer Products, Inc., poly(ethylene glycol) molecular weights run up to about 20,000, while those of poly(ethylene oxide) have 6 or 7 digits.</ref> PEG and PEO are liquids or low-melting solids, depending on their [[molecular weight]]s.  Both are prepared by polymerization of [[ethylene oxide]].  While PEG and PEO with different molecular weights find use in different applications and have different physical properties (e.g. [[viscosity]]) due to chain length effects, their chemical properties are nearly identical.  Derivatives of PEG and PEO are in common use, the most common derivative being the methyl ether (methoxypoly (ethylene glycol)), abbreviated mPEG.


Their melting points vary depending on the Formula Weight of the polymer.  PEG or PEO has the following structure:


:HO-(CH<sub>2</sub>-CH<sub>2</sub>-O)<sub>n</sub>-H
<!--Postmarketing Experience-->
|postmarketing=* [[Diarrhea]], [[Flatulence]], [[Nausea]], [[Stomach cramps]]
|drugInteractions=


The numbers that are often included in the names of PEGs and PEOs indicate their average molecular weights, e.g. a PEG with n=80 would have an average molecular weight of approximately 3500 daltons and would be labeled PEG 3500.  Most PEGs and PEOs include molecules with a distribution of molecular weights, i.e. they are polydisperse.  The size distribution can be characterized statistically by its [[weight average molecular weight]] (Mw) and its [[number average molecular weight]] (Mn), the ratio of which is called the [[polydispersity index]] (Mw/Mn).  Mw and Mn can be measured by [[mass spectroscopy]].
<!--Use in Specific Populations-->
|useInPregnancyFDA=* If pregnant or breast-feeding,
ask a health professional before use.
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''


[[PEGylation]] is the act of covalently coupling a PEG structure to another larger [[molecule]], for example, a [[therapeutic protein]] (which is then referred to as '''PEGylated'''). [[PEGylated interferon alfa-2a]] or -2b is a commonly used injectable treatment for [[Hepatitis C]] infection.
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInNursing=If pregnant or breast-feeding,
ask a health professional before use.
|useInPed=safety and effectiveness not established in children
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.


PEG is soluble in [[water]], [[methanol]], [[benzene]], [[dichloromethane]] and is insoluble in [[diethyl ether]] and [[hexane]]. It is coupled to hydrophobic molecules to produce non-ionic [[surfactant]]s.
<!--Administration and Monitoring-->
|administration=* [[Oral]]
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


==Production==
Poly (ethylene glycol) is produced by the interaction of [[ethylene oxide]] with water, [[ethylene glycol]] or ethylene glycol oligomers.[http://chemindustry.ru/Polyethylene_Glycol.php] The reaction is catalyzed by acidic or basic catalysts. Ethylene glycol and its oligomers are preferable as a starting material instead of water, because it allows the creation of polymers with a low [[polydispersity]] (narrow molecular weight distribution). Polymer chain length depends on the ratio of reactants.


'''HOCH<sub>2</sub>CH<sub>2</sub>OH + n(CH<sub>2</sub>CH<sub>2</sub>O) → HO(CH<sub>2</sub>CH<sub>2</sub>O)<sub>n+1</sub>H'''


Depending on the catalyst type, the mechanism of polymerization can be cationic or anionic. The anionic mechanism is preferable because it allows one to obtain PEG with a low [[polydispersity]]. [[Polymerization]] of ethylene oxide is an exothermic process. Overheating or contaminating ethylene oxide with catalysts such as alkalis or metal oxides can lead to runaway polymerization which can end with an explosion after few hours.
<!--IV Compatibility-->
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.
 
<!--Overdosage-->
|overdose=In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
|drugBox={{chembox2
| Verifiedfields = changed
| verifiedrevid = 477163023
| ImageFile = Poly wiki.png
| ImageSize = 200
| IUPACName = poly(oxyethylene) <small>{structure-based}</small>,<br> poly(ethylene oxide) <small>{source-based}</small><ref>{{cite journal|author=J. Kahovec, R. B. Fox and K. Hatada|title=Nomenclature of regular single-strand organic polymers|journal=Pure and Applied Chemistry|year=2002|volume=74|issue=10|pages=1921–1956|doi=10.1351/pac200274101921}}</ref>
| OtherNames = Carbowax, GoLYTELY, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, Macrogol, MiraLAX, MoviPrep
| Section1 = {{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 25322-68-3
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 3WJQ0SDW1A
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201478
| PubChem =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = NA
| ATCCode_prefix = A06
| ATCCode_suffix = AD15
}}
| Section2 = {{Chembox Properties
| Formula = C<sub>2n</sub>H<sub>4n+2</sub>O<sub>n+1</sub>
| MolarMass = variable
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
}}
| Section3 = {{Chembox Hazards
| MainHazards =
| FlashPt = {{convert|182|to|287|C|C F K|disp=output only}}
| AutoignitionC =
}}
}}
 
 
<!--Mechanism of Action-->
|mechAction=*
 
<!--Structure-->
|structure=* ACTIVE INGREDIENT (IN EACH DOSE)
Polyethylene Glycol 3350, 17 g (in each level scoop)
 


Polyethylene oxide or high-molecular polyethylene glycol is synthesized by [[suspension polymerization]]. It is necessary to hold the growing polymer chain in solution in the course of the polycondensation process. The reaction is catalyzed by magnesium-, aluminium- or calcium-organoelement compounds. To prevent [[coagulation]] of polymer chains from solution, chelating additives such as [[dimethylglyoxime]] are used.


Alkali catalysts such as [[sodium hydroxide]] NaOH, [[potassium hydroxide]] KOH or [[sodium carbonate]] Na<sub>2</sub>CO<sub>3</sub> are used to prepare low-molecular polyethylene glycol.


==Clinical uses== 
<!--Pharmacodynamics-->
Polyethylene glycol has a low toxicity<ref>{{cite book | author = Victor O. Sheftel | title = Indirect Food Additives and Polymers: Migration and Toxicology | year = 2000 | pages = 1114-1116 | publisher = CRC | url = http://www.mindfully.org/Plastic/Polymers/Polyethylene-Glycols-PEGs.htm}}</ref> and is used in a variety of products. It is the basis of a number of [[laxative]]s (e.g. [[macrogol]]-containing products such as [[Movicol]] and polyethylene glycol 3350, or MiraLax or GlycoLax). It is the basis of many [[skin cream]]s, as ''cetomacrogol'', and [[sexual lubricant]]s, frequently combined with [[glycerin]]. [[Whole bowel irrigation]] (polyethylene glycol with added electrolytes) is used for bowel preparation before [[surgery]] or [[colonoscopy]] and drug overdoses.  It is sold under the brand names '''GoLYTELY''', '''GlycoLax''', '''Fortrans''', '''TriLyte''', and '''Colyte'''.  When attached to various protein [[medication]]s, polyethylene glycol allows a slowed clearance of the carried protein from the blood. This makes for a longer acting medicinal effect and reduces [[toxicity]], and it allows longer dosing intervals. Examples include PEG-[[interferon|interferon alpha]] which is used to treat [[hepatitis C]] and PEG-[[filgrastim]] (Neulasta®) which is used to treat [[neutropenia]].  It has been shown that polyethylene glycol can improve healing of [[vertebral column|spinal]] injuries in dogs.<ref>{{cite news | url = http://seattlepi.nwsource.com/health/202292_spinal04.html | date = 4 December 2004 | title = Study on dogs yields hope in human paralysis treatment | author = Lee Bowman | publisher = seattlepi.com}}</ref> One of the earlier findings that polyethylene glycol can aid in nerve repair came from the University of Texas (Krause and Bittner).<ref>{{cite journal | author = T. L. Krause and G. D. Bittner | title = Rapid Morphological Fusion of Severed Myelinated Axons by Polyethylene Glycol | year = 1990 | journal = [[PNAS]] | volume = 87 | issue = 4 | pages = 1471-1475 | url = http://www.pnas.org/cgi/content/abstract/87/4/1471}}</ref> Polyethylene glycol is commonly used to fuse B-cells with [[myeloma]] cells in [[monoclonal antibody]] production.PEG has recently been proved to give better results in constipation patients than tegaserod.<ref> Di Palma JA et al. Am J Gastroenterol 2007 Sep 102:1964 </ref>
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.


===Research for New Clinical Uses===
<!--Pharmacokinetics-->
* High-molecular weight PEG, e.g., PEG 8000, is a strikingly potent dietary preventive agent against [[colorectal cancer]] in animal models.<ref>{{cite journal | author = D. E. Corpet, G. Parnaud, M. Delverdier, G. Peiffer and S. Tache | title = Consistent and Fast Inhibition of Colon Carcinogenesis by Polyethylene Glycol in Mice and Rats Given Various Carcinogens | year = 2000 | journal = [[Cancer Res]] | volume = 60 | issue = 12 | pages = 3160-3164 | url = http://cancerres.aacrjournals.org/cgi/content/full/60/12/3160}}</ref>
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.


The [http://www.inra.fr/reseau-nacre/sci-memb/corpet/indexan.html Chemoprevention Database] shows it is the most effective agent to suppress chemical carcinogenesis in rats. Cancer prevention in humans has not yet been tested in clinical trials.
<!--Nonclinical Toxicology-->
* The injection of PEG 2000 into the bloodstream of guinea pigs after spinal cord injury leads to rapid recovery through molecular repair of nerve membranes.<ref>{{cite journal | author = R. B. Borgens and D. Bohnert | title = Rapid recovery from spinal cord injury after subcutaneously administered polyethylene glycol | year = 2001 | journal = [[Journal of Neuroscience Research]] | volume = 66 | issue = 6 | pages = 1179-1186 | doi = 10.1002/jnr.1254}}</ref> The effect of this treatment to prevent [[paraplegia]] in humans after an accident is not known yet.
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.
* Research is being done in the use of PEG to mask antigens on red blood cells. Various research institutes have reported that using PEG can mask antigens without damaging the functions and shape of the cell.


==Other uses==
<!--Clinical Studies-->
PEG is used in a number of [[toothpaste]]s as a [[dispersant]]; it binds water and helps keep [[Xanthan gum|gum]] uniform throughout the toothpaste.  It is also under investigation for use in [[body armor]]<ref>{{Cite news | author = Tonya Johnson | publisher = [[Military.com]] | title = Army Scientists, Engineers develop Liquid Body Armor | url = http://www.military.com/NewsContent/0,13319,usa3_042104.00.html | date = 21 April 2004}}</ref> and [[tattoo]]s to monitor [[diabetes]].<ref>{{cite news | publisher = [[BBC News]] | date = 1 September 2002 | title = Tattoo to monitor diabetes | url = http://news.bbc.co.uk/2/hi/health/2225404.stm}}</ref> [[Functional group]]s of PEG give [[polyurethane]] [[elastomer]]s their "rubberiness", for applications such as [[foam]]s (foam rubber) and [[fiber]]s ([[spandex]]).  Its backbone structure is analogous to that of [[silicone]], another elastomer.
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.


Since PEG is a flexible, water-soluble polymer, it can be used to create very high [[osmotic pressure]]s (tens of atmospheres).  It also is unlikely to have specific interactions with biological chemicals.  These properties make PEG one of the most useful molecules for applying osmotic pressure in [[biochemistry]] experiments, particularly when using the [[osmotic stress technique]].{{Fact|date=July 2007}}
<!--How Supplied-->
|howSupplied=*
|storage=* store at 20°-25°C (68°-77°F)
* tamper-evident: do not use if printed foil seal under cap is missing, open or broken
|packLabel=====PRINCIPAL DISPLAY PANEL====


PEO (poly (ethylene oxide)) can serve as the separator and [[electrolyte]] [[solvent]] in [[lithium polymer cell]]s. Its low [[diffusion|diffusivity]] often requires high temperatures of operation, but its high viscosity even near its [[melting point]] allows very thin electrolyte layers.  While [[crystallization]] of the polymer can degrade performance, many of the salts used to carry charge can also serve as a [[kinetic barrier]] to the formation of crystals. Such batteries carry greater energy for their weight than other [[lithium ion battery]] technologies.
: [[File:Poly PDP.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]


When working with [[phenol]] in a laboratory situation, PEG 300 can be used on phenol skin burns to deactivate any residual phenol.
====Ingredients and Appearance====
: [[File:Poly I n A.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]


Poly (ethylene glycol) is also commonly used as a polar stationary phase for [[gas chromatography]], as well as a [[heat transfer fluid]] in electronic testers.


PEG is included in many or all formulations of the soft drink [[Dr Pepper]], purportedly as an anti-foaming agent.


PEG has also been used to preserve objects which have been salvaged from underwater, as was the case with the warship [[Regalskeppet Vasa|Vasa]] in Stockholm.<ref>Lars-Åke Kvarning, Bengt Ohrelius (1998), ''The Vasa - The Royal Ship'', ISBN 91-7486-581-1, pp. 133-141</ref> It replaces water in wooden objects, which makes the wood dimensionally stable and prevents warping or shrinking of the wood.
<!--Patient Counseling Information-->
|fdaPatientInfo=QUESTIONS OR COMMENTS?
1-800-719-9260


PEG is often seen (as a side effect) in mass spectrometry experiments with characteristic fragmentation patterns.
<!--Precautions with Alcohol-->
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.


In the field of [[microbiology]], PEG precipitation is used to concentrate viruses.
<!--Brand Names-->
|brandNames=* CLEAR LAX®<ref>{{Cite web | title = Polyethylene glycol  | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b772c441-c7ea-4c3f-9e80-1e5200d11d51}}</ref>


PEG is also used in lubricant eye drops. PEG derivatives such as [[narrow range ethoxylate]]s are used as [[surfactant]]s.
<!--Look-Alike Drug Names-->
|lookAlike=There is no information regarding look alike drug names
|drugShortage=
}}


==References==
{{reflist|2}}


==External links==
* [http://chemindustry.ru/Polyethylene_Glycol.php polyethylene glycol - chemical product info: properties, production, applications.]


==See Also==
<!--Category-->
*[[PEGylation]]


[[Category:Polyethers]]
[[Category:Drug]]
[[Category:Laxatives]]
[[Category:Solvents]]
[[Category:Coolants]]

Latest revision as of 13:53, 27 April 2015

Polyethylene glycol
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

Disclaimer

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Polyethylene glycol is a Laxative that is FDA approved for the treatment of constipation. Common adverse reactions include Diarrhea, Flatulence, Nausea, Stomach cramps.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

  • relieves occasional constipation (irregularity)
  • generally produces a bowel movement in 1 to 3 days

Directions

  • do not take more than directed unless advised by your doctor
  • the enclosed scoop is a measuring device designed to contain 17 grams of powder when filled to the top (level scoop)
  • adults and children 17 years of age and older:
  • fill scoop completely with product to obtain the correct dose (17 g). Level scoop with knife or flat object.
  • stir and dissolve in any 4 to 8 ounces of beverage (cold, hot or room temperature) then drink
  • use once a day
  • use no more than 7 days
  • children 16 years of age or under: ask a doctor

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Polyethylene glycol in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Polyethylene glycol in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

safety and effectiveness not established in children

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Polyethylene glycol in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Polyethylene glycol in pediatric patients.

Contraindications

There is limited information regarding Polyethylene glycol Contraindications in the drug label.

Warnings

  • Allergy alert: Do not use if you are allergic to polyethylene glycol
  • Do not use
  • if you have kidney disease, except under the advice and supervision of a doctor
  • Ask a doctor before use if you have
  • Ask a doctor or pharmacist before use if you are
  • taking a prescription drug
  • When using this product
  • you may have loose, watery, more frequent stools
  • Stop use and ask a doctor if
  • If pregnant or breast-feeding,
  • ask a health professional before use.
  • Keep out of reach of children.
  • In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Polyethylene glycol in the drug label.

Postmarketing Experience

Drug Interactions

There is limited information regarding Polyethylene glycol Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • If pregnant or breast-feeding,

ask a health professional before use.
Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Polyethylene glycol in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Polyethylene glycol during labor and delivery.

Nursing Mothers

If pregnant or breast-feeding, ask a health professional before use.

Pediatric Use

safety and effectiveness not established in children

Geriatic Use

There is no FDA guidance on the use of Polyethylene glycol with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Polyethylene glycol with respect to specific gender populations.

Race

There is no FDA guidance on the use of Polyethylene glycol with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Polyethylene glycol in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Polyethylene glycol in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Polyethylene glycol in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Polyethylene glycol in patients who are immunocompromised.

Administration and Monitoring

Administration

Monitoring

There is limited information regarding Monitoring of Polyethylene glycol in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Polyethylene glycol in the drug label.

Overdosage

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Pharmacology

Template:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox E numberTemplate:Chembox FlashPtTemplate:Chembox Supplement
Template:Chembox header2 | Polyethylene glycol
Identifiers
ChEMBL
ChemSpider
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
UNII
Properties
C2nH4n+2On+1
Molar mass variable
Hazards
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

Structure

  • ACTIVE INGREDIENT (IN EACH DOSE)

Polyethylene Glycol 3350, 17 g (in each level scoop)

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Polyethylene glycol in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Polyethylene glycol in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Polyethylene glycol in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Polyethylene glycol in the drug label.

How Supplied

Storage

  • store at 20°-25°C (68°-77°F)
  • tamper-evident: do not use if printed foil seal under cap is missing, open or broken

Images

Drug Images

{{#ask: Page Name::Polyethylene glycol |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

PRINCIPAL DISPLAY PANEL

This image is provided by the National Library of Medicine.

Ingredients and Appearance

This image is provided by the National Library of Medicine.

{{#ask: Label Page::Polyethylene glycol |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

QUESTIONS OR COMMENTS? 1-800-719-9260

Precautions with Alcohol

  • Alcohol-Polyethylene glycol interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is no information regarding look alike drug names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ "Polyethylene glycol".
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