Polycythemia vera epidemiology and demographics: Difference between revisions
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The median age of polycythemia vera is 61 years.<ref name="pmid26324368">{{cite journal| author=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK et al.| title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F. | journal=J Clin Oncol | year= 2015 | volume= 33 | issue= 33 | pages= 3953-60 | pmid=26324368 | doi=10.1200/JCO.2015.61.6474 | pmc=4979103 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26324368 }} </ref><ref name="pmid25353086">{{cite journal| author=Verstovsek S, Komrokji RS| title=Novel and emerging therapies for the treatment of polycythemia vera. | journal=Expert Rev Hematol | year= 2015 | volume= 8 | issue= 1 | pages= 101-13 | pmid=25353086 | doi=10.1586/17474086.2015.972359 | pmc=4934659 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25353086 }} </ref> Polycythemia vera occurs in all age groups (including children). The incidence increases with age. Polycythemia vera commonly affects people older than 60.<ref name="seercancergov">National Cancer Institute. Polycythemia vera 2015.http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd538d/</ref><ref>{{cite journal | author = Passamonti F, Malabarba L, Orlandi E, Baratè C, Canevari A, Brusamolino E, Bonfichi M, Arcaini L, Caberlon S, Pascutto C, Lazzarino M | title = Polycythemia vera in young patients: a study on the long-term risk of thrombosis, myelofibrosis and leukemia. | journal = Haematologica | volume = 88 | issue = 1 | pages = 13-8 | year = 2003 | id = PMID 12551821}}</ref><ref name="pvsg">Berlin, NI. (1975). "Diagnosis and classification of polycythemias". ''Semin Hematol'' '''12''': 339.</ref> Younger patients are more likely to develop unusual complications such as mesenteric venous thrombosis. The rate of transformation to acute leukemia is similar as that of older adults.<ref name="pmid26324368">{{cite journal| author=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK et al.| title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F. | journal=J Clin Oncol | year= 2015 | volume= 33 | issue= 33 | pages= 3953-60 | pmid=26324368 | doi=10.1200/JCO.2015.61.6474 | pmc=4979103 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26324368 }} </ref> | The median age of polycythemia vera is 61 years.<ref name="pmid26324368">{{cite journal| author=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK et al.| title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F. | journal=J Clin Oncol | year= 2015 | volume= 33 | issue= 33 | pages= 3953-60 | pmid=26324368 | doi=10.1200/JCO.2015.61.6474 | pmc=4979103 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26324368 }} </ref><ref name="pmid25353086">{{cite journal| author=Verstovsek S, Komrokji RS| title=Novel and emerging therapies for the treatment of polycythemia vera. | journal=Expert Rev Hematol | year= 2015 | volume= 8 | issue= 1 | pages= 101-13 | pmid=25353086 | doi=10.1586/17474086.2015.972359 | pmc=4934659 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25353086 }} </ref> Polycythemia vera occurs in all age groups (including children). The incidence increases with age. Polycythemia vera commonly affects people older than 60 since mutations are more likely to develop with aging.<ref name="seercancergov">National Cancer Institute. Polycythemia vera 2015.http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd538d/</ref><ref>{{cite journal | author = Passamonti F, Malabarba L, Orlandi E, Baratè C, Canevari A, Brusamolino E, Bonfichi M, Arcaini L, Caberlon S, Pascutto C, Lazzarino M | title = Polycythemia vera in young patients: a study on the long-term risk of thrombosis, myelofibrosis and leukemia. | journal = Haematologica | volume = 88 | issue = 1 | pages = 13-8 | year = 2003 | id = PMID 12551821}}</ref><ref name="pvsg">Berlin, NI. (1975). "Diagnosis and classification of polycythemias". ''Semin Hematol'' '''12''': 339.</ref> Younger patients are more likely to develop unusual complications such as mesenteric venous thrombosis. The rate of transformation to acute leukemia is similar as that of older adults.<ref name="pmid26324368">{{cite journal| author=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK et al.| title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F. | journal=J Clin Oncol | year= 2015 | volume= 33 | issue= 33 | pages= 3953-60 | pmid=26324368 | doi=10.1200/JCO.2015.61.6474 | pmc=4979103 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26324368 }} </ref> | ||
===Gender=== | ===Gender=== | ||
Revision as of 00:59, 19 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
The incidence of polycythemia vera is approximately 0.7 to 2.6 per 100,000 individuals in the US.[1]
Epidemiology and Demographics
Incidence
The incidence of polycythemia vera is approximately 0.7 to 2.6 per 100,000 individuals in the US.[1]
Prevalence
The prevalence of polycythemia vera is 48 to 57 cases per 100,000 individuals in the United States. This represents the age-adjusted prevalence as of 2010. The prevalence of polycythemia vera is 5 to 30 cases per 100,000 individuals in Europe.[2] Approximately 148,000 persons are living with polycythemia vera currently.[3] It is likely that this is an underestimate of the true prevalence, as many patients are asymptomatic.[3]
Age
The median age of polycythemia vera is 61 years.[3][2] Polycythemia vera occurs in all age groups (including children). The incidence increases with age. Polycythemia vera commonly affects people older than 60 since mutations are more likely to develop with aging.[1][4][5] Younger patients are more likely to develop unusual complications such as mesenteric venous thrombosis. The rate of transformation to acute leukemia is similar as that of older adults.[3]
Gender
Males are more commonly affected with polycythemia vera than females, with a male to female ratio of 6.5:3.5.[1][2][2] However, in patients under age 40, there is a female predominance of 7.5:2.5.
Life expectancy
The life expectancy after diagnosis is 13.5 years.[2]
References
- ↑ 1.0 1.1 1.2 1.3 National Cancer Institute. Polycythemia vera 2015.http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd538d/
- ↑ 2.0 2.1 2.2 2.3 2.4 Verstovsek S, Komrokji RS (2015). "Novel and emerging therapies for the treatment of polycythemia vera". Expert Rev Hematol. 8 (1): 101–13. doi:10.1586/17474086.2015.972359. PMC 4934659. PMID 25353086.
- ↑ 3.0 3.1 3.2 3.3 Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK; et al. (2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J Clin Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.
- ↑ Passamonti F, Malabarba L, Orlandi E, Baratè C, Canevari A, Brusamolino E, Bonfichi M, Arcaini L, Caberlon S, Pascutto C, Lazzarino M (2003). "Polycythemia vera in young patients: a study on the long-term risk of thrombosis, myelofibrosis and leukemia". Haematologica. 88 (1): 13–8. PMID 12551821.
- ↑ Berlin, NI. (1975). "Diagnosis and classification of polycythemias". Semin Hematol 12: 339.