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{{DiseaseDisorder infobox |
__NOTOC__
Name          = Pleomorphic adenoma |
ICD10          = {{ICD10|D|11||d|10}} |
ICD9          = {{ICD9|210.2}} |
ICDO          = 8940/0 |
Image          = Pleomorphic adenoma (1) parotid gland.jpg |
Caption        = Pleomorphic adenoma consists of mixed epithelial (left) and mesenchymal cell components (right). The latter often exhibits myxofibrous appearance and in some instances shows chondromatous differentiation. |
OMIM          = 181030 |
OMIM_mult      = |
MedlinePlus    = |
eMedicineSubj  = |
eMedicineTopic = |
DiseasesDB    = |
MeshID        = D008949 |
}}
{{Pleomorphic adenoma}}
{{Pleomorphic adenoma}}
{{CMG}}; '''Associate Editors-In-Chief''': [[User:zorkun|Cafer Zorkun]] M.D., PhD.
'''For patient information, click [[Pleomorphic adenoma (patient information)|here]]'''


==[[Pleomorphic adenoma overview|Overview]]==
{{CMG}}; {{AE}} {{M.N}}


==[[Pleomorphic adenoma history and symptoms|History & Symptoms]]==
{{SK}}


==Diagnosis==
==[[Pleomorphic adenoma overview|Overview]]==
==[[Pleomorphic adenoma MRI|MRI]]==
 
==[[Pleomorphic adenoma CT|CT]]==
 
==[[Pleomorphic adenoma echocardiography or ultrasound|Echocardiography or Ultrasound]]==
 
==[[Pleomorphic adenoma other diagnostic studies|Other Diagnostic Studies]]==


==[[Pleomorphic adenoma historical perspective|Historical Perspective]]==


The diagnosis of salivary gland tumors utilize both histopathological sampling and radiographic studies. Histopathological sampling procedures include [[fine needle aspiration]] (FNA) and core needle biopsy (bigger needle comparing to FNA). Both of these procedures can be done in an outpatient setting.  Diagnostic imaging techniques for salivary gland tumors include [[ultrasound]], [[computer tomography]] (CT) and [[magnetic resonance imaging]] (MRI).  Fine needle aspiration biopsy (FNA), operated in experienced hands, can determine whether the tumor is malignant in nature with [[sensitivity]] around 90%<ref>{{cite journal |author=Cohen EG, Patel SG, Lin O, ''et al'' |title=Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population |journal=Arch Otolaryngol Head Neck Surg |volume=130 |issue=6 |pages=773–8 |year=2004 |month=Jun |pmid=15210562 |doi=10.1001/archotol.130.6.773 |url=}}</ref><ref>{{cite journal |author=Batsakis JG, Sneige N, el-Naggar AK |title=Fine-needle aspiration of salivary glands: its utility and tissue effects |journal=Ann Otol Rhinol Laryngol |volume=101 |issue=2 Pt 1 |pages=185–8 |year=1992 |month=Feb |pmid=1739267 |doi= |url=}}</ref>. FNA can also distinguish primary salivary tumor from metastatic disease.  Core needle biopsy can also be done in outpatient setting. It is more invasive but is more accurate compared to FNA with diagnostic [[accuracy]] greater than 97%<ref>{{cite journal |author=Wan YL, Chan SC, Chen YL, ''et al'' |title=Ultrasonography-guided core-needle biopsy of parotid gland masses |journal=AJNR Am J Neuroradiol |volume=25 |issue=9 |pages=1608–12 |year=2004 |month=Oct |pmid=15502149 |doi= |url=http://www.ajnr.org/cgi/pmidlookup?view=long&pmid=15502149}}</ref>. Furthermore, core needle biopsy allows more accurate histological typing of the tumor.  In terms of imaging studies, ultrasound can determine and characterize superficial parotid tumors. Certain types of salivary gland tumors have certain sonographic characteristics on ultrasound<ref>{{cite journal |author=Białek EJ, Jakubowski W, Karpińska G |title=Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress |journal=Arch Otolaryngol Head Neck Surg |volume=129 |issue=9 |pages=929–33 |year=2003 |month=Sep |pmid=12975263 |doi=10.1001/archotol.129.9.929 |url=}}</ref>. Ultrasound is also frequently used to guide FNA or core needle biopsy.  CT allows direct, bilateral visualization of the salivary gland tumor and provides information about overall dimension and tissue invasion. CT is excellent for demonstrating bony invasion. MRI provides superior soft tissue delineation such as perineural invasion when compared to CT only<ref>{{cite journal |author=Koyuncu M, Seşen T, Akan H, ''et al'' |title=Comparison of computed tomography and magnetic resonance imaging in the diagnosis of parotid tumors |journal=Otolaryngol Head Neck Surg |volume=129 |issue=6 |pages=726–32 |year=2003 |month=Dec |pmid=14663442 |doi=10.1016/j.otohns.2003.07.009 |url=}}</ref>.
==[[Pleomorphic adenoma classification|Classification]]==


==[[Pleomorphic adenoma pathophysiology|Pathophysiology]]==
==[[Pleomorphic adenoma pathophysiology|Pathophysiology]]==


==Treatment==
==[[Pleomorphic adenoma causes|Causes]]==
==[[Pleomorphic adenoma surgery|Surgery]]==


==References==
==[[Pleomorphic adenoma differential diagnosis|Differentiating Pleomorphic Adenoma from other Diseases]]==


{{reflist|2}}
==[[Pleomorphic adenoma epidemiology and demographics|Epidemiology and Demographics]]==


==See also==
==[[Xyz risk factors|Risk Factors]]==
* [[Warthin's tumor]] - monomorphic adenoma


==External links==
==[[Pleomorphic adenoma screening|Screening]]==
* {{GPnotebook|-1804926964}}
* [http://brighamrad.harvard.edu/Cases/bwh/hcache/75/full.html Harvard]


==[[Pleomorphic adenoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


{{Soft tissue tumors and sarcomas}}
==Diagnosis==
{{Tumors of lip, oral cavity and pharynx}}
[[Pleomorphic adenoma diagnostic study of choice|Diagnostic study of choice]] | [[Pleomorphic adenoma history and symptoms|History and Symptoms]] | [[Pleomorphic adenoma physical examination|Physical Examination]] | [[Pleomorphic adenoma laboratory findings|Laboratory Findings]] | [[Pleomorphic adenoma electrocardiogram|Electrocardiogram]] | [[Pleomorphic adenoma x ray|X-Ray Findings]] | [[Pleomorphic adenoma echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Pleomorphic adenoma CT scan|CT-Scan Findings]] | [[Pleomorphic adenoma MRI|MRI Findings]] | [[Pleomorphic adenoma other imaging findings|Other Imaging Findings]] | [[Pleomorphic adenoma other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
[[Pleomorphic adenoma medical therapy|Medical Therapy]] | [[Pleomorphic adenoma surgery|Surgery]] | [[Pleomorphic adenoma primary prevention|Primary Prevention]] | [[Pleomorphic adenoma secondary prevention|Secondary Prevention]] | [[Pleomorphic adenoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Pleomorphic adenoma future or investigational therapies|Future or Investigational Therapies]]


[[es:Adenoma pleomórfico]]
==Case Studies==
[[ja:多形性腺腫]]
[[Pleomorphic adenoma case study one|Case #1]]
[[pl:Gruczolak wielopostaciowy]]
[[pt:Adenoma pleomórfico]]
 
[[tr:Pleomorfik adenom]]
 
[[Category:Oral pathology]]
[[Category:Oncology]]
 
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Latest revision as of 14:46, 12 February 2019

Pleomorphic adenoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pleomorphic adenoma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT scan

MRI

Echocardiography and Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2]

Synonyms and keywords:

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pleomorphic Adenoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1