Placenta specific 8

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Placenta specific 8 is a protein that in humans is encoded by the PLAC8 gene.

Further reading

• Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ (2010). "The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation". Leukemia. 24 (3): 544–51. doi:10.1038/leu.2009.280. PMID 20072156.
• Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams GT (2013). "Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types". Curr Cancer Drug Targets. 13 (1): 80–91. PMID 22920440.
• Uehara H, Takahashi T, Izumi K (2013). "Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin". Int. J. Oncol. 43 (2): 365–74. doi:10.3892/ijo.2013.1954. PMC 3775580. PMID 23708710.
• Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ (2014). "Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer". J. Clin. Invest. 124 (5): 2172–87. doi:10.1172/JCI71103. PMC 4001536. PMID 24691442.
• Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H (2014). "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression". Cell Rep. 7 (4): 1143–55. doi:10.1016/j.celrep.2014.03.061. PMC 4112575. PMID 24794439.
• Blue EK, Sheehan BM, Nuss ZV, Boyle FA, Hocutt CM, Gohn CR, Varberg KM, McClintick JN, Haneline LS (2015). "Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus". Diabetes. 64 (7): 2664–75. doi:10.2337/db14-1709. PMC 4477353. PMID 25720387.
• Kaistha BP, Lorenz H, Schmidt H, Sipos B, Pawlak M, Gierke B, Kreider R, Lankat-Buttgereit B, Sauer M, Fiedler L, Krattenmacher A, Geisel B, Kraus JM, Frese KK, Kelkenberg S, Giese NA, Kestler HA, Gress TM, Buchholz M (2016). "PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways". Cancer Res. 76 (1): 96–107. doi:10.1158/0008-5472.CAN-15-0216. PMID 26669866.
• Li M, Liu D, Wang L, Wang W, Wang A, Yao Y (2016). "Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation". Fertil. Steril. 106 (3): 781–789.e2. doi:10.1016/j.fertnstert.2016.05.018. PMID 27322877.