Pineal embryonal carcinoma: Difference between revisions
Jump to navigation
Jump to search
| Line 26: | Line 26: | ||
*Pineal embryonal carcinoma is demonstrated by positivity to [[tumor markers]] such as:<ref name=ihc1pec>IHC features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015</ref> | *Pineal embryonal carcinoma is demonstrated by positivity to [[tumor markers]] such as:<ref name=ihc1pec>IHC features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015</ref> | ||
*Pineal embryonal carcinoma must be differentiated from: | *Pineal embryonal carcinoma must be differentiated from: | ||
*[[Pineocytoma]] | :*[[Pineocytoma]] | ||
*[[Pineal parenchymal tumor with intermediate differentiation]] | :*[[Pineal parenchymal tumor with intermediate differentiation]] | ||
*[[Papillary tumor of the pineal region]] | :*[[Papillary tumor of the pineal region]] | ||
*[[Pineoblastoma]] | :*[[Pineoblastoma]] | ||
*[[Pineal germinoma]] | :*[[Pineal germinoma]] | ||
*Pineal choriocarcinoma | :*Pineal choriocarcinoma | ||
*Pineal yolk sac carcinoma (endodermal sinus tumor) | :*Pineal yolk sac carcinoma (endodermal sinus tumor) | ||
*Pineal teratoma | :*Pineal teratoma | ||
*[[Pineal gland cyst|Pineal cyst]] | :*[[Pineal gland cyst|Pineal cyst]] | ||
*[[Astrocytoma]] of the pineal gland | :*[[Astrocytoma]] of the pineal gland | ||
*[[Meningioma]] near pineal gland | :*[[Meningioma]] near pineal gland | ||
*[[Intracerebral metastases|Pineal metastasis]] | :*[[Intracerebral metastases|Pineal metastasis]] | ||
*[[Cavernoma]] in pineal region | :*[[Cavernoma]] in pineal region | ||
*[[Aneurysm]] in pineal region | :*[[Aneurysm]] in pineal region | ||
==References== | ==References== | ||
Revision as of 21:06, 4 December 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and keywords:
Overview
- Pineal embryonal carcinoma is a relatively rare malignant neoplasm and accounts for a small prportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. A component of embryonal carcinoma is often found in mixed germ-cell tumours, in which case it usually the most aggressive component, and dictates prognosis. Pure pineal embryonal carcinoma tumors do not secrete β-HCG or AFP.[1]
- On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by:[2]
- Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation
- Indistinct cell borders
- Nucleoli - key feature
- Vesicular nuclei (clear, empty appearing nuclei) - key feature
- Necrosis - common
- Mitoses - common
- Variable architecture:
- Solid (predominant in ~55% of cases)
- Glandular (predominant in ~17% of cases)
- Papillary (predominant in ~11% of cases)
- Nested
- Micropapillary
- Anastomosing glandular
- Sieve-like glandular
- Pseudopapillary
- Blastocyst-like
- Embryoid bodies - ball of cells in surrounded by empty space on three sides
- Pineal embryonal carcinoma is demonstrated by positivity to tumor markers such as:[3]
- Pineal embryonal carcinoma must be differentiated from:
- Pineocytoma
- Pineal parenchymal tumor with intermediate differentiation
- Papillary tumor of the pineal region
- Pineoblastoma
- Pineal germinoma
- Pineal choriocarcinoma
- Pineal yolk sac carcinoma (endodermal sinus tumor)
- Pineal teratoma
- Pineal cyst
- Astrocytoma of the pineal gland
- Meningioma near pineal gland
- Pineal metastasis
- Cavernoma in pineal region
- Aneurysm in pineal region
References
- ↑ Intracranial embryonal carcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-embryonal-carcinoma. Accessed on December 4, 2015
- ↑ Microscopic features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015
- ↑ IHC features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015