Phenoxybenzamine: Difference between revisions

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[[pheochromocytoma]], to control episodes of [[hypertension]] and [[sweating]].


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Revision as of 15:56, 26 July 2014

Phenoxybenzamine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

Disclaimer

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Overview

Phenoxybenzamine is a vasodilator and alpha-adrenergic blocker that is FDA approved for the {{{indicationType}}} of pheochromocytoma, to control episodes of hypertension and sweating.. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Phenoxybenzamine in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Phenoxybenzamine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Phenoxybenzamine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Phenoxybenzamine in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Phenoxybenzamine in pediatric patients.

Contraindications

  • Condition1

Warnings

  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Phenoxybenzamine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Phenoxybenzamine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Phenoxybenzamine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Phenoxybenzamine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Phenoxybenzamine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Phenoxybenzamine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Phenoxybenzamine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Phenoxybenzamine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Phenoxybenzamine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Phenoxybenzamine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Phenoxybenzamine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Phenoxybenzamine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Phenoxybenzamine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Phenoxybenzamine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Phenoxybenzamine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Phenoxybenzamine in the drug label.

Pharmacology

Template:Px
1 : 1 mixture (racemate)Phenoxybenzamine
Systematic (IUPAC) name
(RS)-N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine
Identifiers
CAS number 59-96-1
ATC code C04AX02
PubChem 4768
DrugBank DB00925
Chemical data
Formula Template:OrganicBox atomTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox 
Mol. mass 303.826 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life 24 hours
Excretion ?
Therapeutic considerations
Pregnancy cat.

C (U.S.)

Legal status
Routes Oral

Mechanism of Action

Structure

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Phenoxybenzamine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Phenoxybenzamine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Phenoxybenzamine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Phenoxybenzamine in the drug label.

How Supplied

Storage

There is limited information regarding Phenoxybenzamine Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Phenoxybenzamine in the drug label.

Precautions with Alcohol

  • Alcohol-Phenoxybenzamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • Dibenzyline®[1]

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. "DIBENZYLINE (phenoxybenzamine hydrochloride) capsule".
  2. "http://www.ismp.org". External link in |title= (help)


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