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{{Peutz-Jeghers syndrome}}
{{Peutz-Jeghers syndrome}}


{{CMG}} {{AE}} {{MJK}}
{{CMG}}; {{AE}} {{HQ}}


==Overview==
==Overview==
Symptoms of Peutz-Jeghers syndrome include mucocutaneous hyperpigmentation, [[rectal bleeding]], [[abdominal pain]], and [[weight loss]].
The hallmark of Peutz-Jeghers syndrome is hamatomatous [[Polyp|polyps]]. A positive history of mucucutaneous [[hyperpigmentation]] and [[rectal bleeding]] is suggestive of Peutz-Jeghers syndrome. The most common symptoms of Peutz-Jeghers syndrome include [[abdominal pain]], [[fatigue]], and [[weight loss]].  
==History and Symptoms==
==History and Symptoms==
Symptoms of Peutz-Jeghers syndrome include the following:<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref>
Individuals with Peutz-Jeghers syndrome may have positive history of:<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref>
*Mucocutaneous hyperpigmentation (mouth, hands, and feet)
* Peutz-Jeghers syndrome in family
* Mucucutaneous [[hyperpigmentation]] of the [[oral mucosa]]
* [[Rectal bleeding|Rectal bleeds]]
* [[Abdominal pain]]
* [[Fatigue]]
Symptoms of Peutz-Jeghers syndrome include the following:<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref><ref name="GiardielloTrimbath2006">{{cite journal|last1=Giardiello|first1=F|last2=Trimbath|first2=J|title=Peutz-Jeghers Syndrome and Management Recommendations|journal=Clinical Gastroenterology and Hepatology|volume=4|issue=4|year=2006|pages=408–415|issn=15423565|doi=10.1016/j.cgh.2005.11.005}}</ref><ref name="urlPeutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program">{{cite web |url=https://rarediseases.info.nih.gov/diseases/7378/peutz-jeghers-syndrome#ref_8500 |title=Peutz-Jeghers syndrome &#124; Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |format= |work= |accessdate=}}</ref>
*Mucocutaneous [[hyperpigmentation]] (mouth, hands, and feet)
*[[Rectal bleeding]]
*[[Rectal bleeding]]
*[[Melena]]
*[[Melena]]
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*[[Hematemesis]]
*[[Hematemesis]]
*[[Fatigue]]
*[[Fatigue]]
<br>
{|
! colspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Percentage of symptom occurrence in Peutz-Jeghers syndrome
|-
! style="background:#7d7d7d; color: #FFFFFF;" align="center" + |Symptoms
! style="background:#7d7d7d; color: #FFFFFF;" align="center" + |Percentage (%)
|-
| style="background:#DCDCDC;" align="center" + |Abnormal [[Hyperpigmentation|Pigmentation]]
| style="background:#F5F5F5;" align="center" + |80 to 90
|-
| style="background:#DCDCDC;" align="center" + |[[Gastrointestinal bleeding|GI Bleeding]]
| style="background:#F5F5F5;" align="center" + |30 to 79
|-
| style="background:#DCDCDC;" align="center" + |[[Abdominal pain|Abdominal Pain]]
| style="background:#F5F5F5;" align="center" + |5 to 29
|}


== References ==
== References ==
{{reflist|2}}
{{reflist|2}}
{{WH}}
{{WS}}
[[Category:Gastroenterology]]
[[Category:Surgery]]
[[Category:Oncology]]
[[Category:Disease]]
[[Category:Pediatrics]]
[[Category:Up-To-Date]]

Latest revision as of 16:50, 21 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]

Overview

The hallmark of Peutz-Jeghers syndrome is hamatomatous polyps. A positive history of mucucutaneous hyperpigmentation and rectal bleeding is suggestive of Peutz-Jeghers syndrome. The most common symptoms of Peutz-Jeghers syndrome include abdominal pain, fatigue, and weight loss.

History and Symptoms

Individuals with Peutz-Jeghers syndrome may have positive history of:[1]

Symptoms of Peutz-Jeghers syndrome include the following:[1][2][3]


Percentage of symptom occurrence in Peutz-Jeghers syndrome
Symptoms Percentage (%)
Abnormal Pigmentation 80 to 90
GI Bleeding 30 to 79
Abdominal Pain 5 to 29

References

  1. ↑ 1.0 1.1 Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). "Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach". World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.
  2. ↑ Giardiello, F; Trimbath, J (2006). "Peutz-Jeghers Syndrome and Management Recommendations". Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.
  3. ↑ "Peutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".

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