Peutz-Jeghers syndrome history and symptoms: Difference between revisions
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{{Peutz-Jeghers syndrome}} | {{Peutz-Jeghers syndrome}} | ||
{{CMG}} {{AE}} {{ | {{CMG}}; {{AE}} {{HQ}} | ||
==Overview== | ==Overview== | ||
The hallmark of Peutz-Jeghers syndrome is hamatomatous [[Polyp|polyps]]. A positive history of mucucutaneous [[hyperpigmentation]] and [[rectal bleeding]] is suggestive of Peutz-Jeghers syndrome. The most common symptoms of Peutz-Jeghers syndrome include [[abdominal pain]], [[fatigue]], and [[weight loss]]. | |||
==History and Symptoms== | ==History and Symptoms== | ||
Symptoms of Peutz-Jeghers syndrome include the following: | Individuals with Peutz-Jeghers syndrome may have positive history of:<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref> | ||
* Peutz-Jeghers syndrome in family | |||
* Mucucutaneous [[hyperpigmentation]] of the [[oral mucosa]] | |||
* [[Rectal bleeding|Rectal bleeds]] | |||
* [[Abdominal pain]] | |||
* [[Fatigue]] | |||
Symptoms of Peutz-Jeghers syndrome include the following:<ref name="KopacovaTacheci2009">{{cite journal|last1=Kopacova|first1=Marcela|last2=Tacheci|first2=Ilja|last3=Rejchrt|first3=Stanislav|last4=Bures|first4=Jan|title=Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach|journal=World Journal of Gastroenterology|volume=15|issue=43|year=2009|pages=5397|issn=1007-9327|doi=10.3748/wjg.15.5397}}</ref><ref name="GiardielloTrimbath2006">{{cite journal|last1=Giardiello|first1=F|last2=Trimbath|first2=J|title=Peutz-Jeghers Syndrome and Management Recommendations|journal=Clinical Gastroenterology and Hepatology|volume=4|issue=4|year=2006|pages=408–415|issn=15423565|doi=10.1016/j.cgh.2005.11.005}}</ref><ref name="urlPeutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program">{{cite web |url=https://rarediseases.info.nih.gov/diseases/7378/peutz-jeghers-syndrome#ref_8500 |title=Peutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |format= |work= |accessdate=}}</ref> | |||
*Mucocutaneous [[hyperpigmentation]] (mouth, hands, and feet) | |||
*[[Rectal bleeding]] | *[[Rectal bleeding]] | ||
*[[Melena]] | |||
*[[Rectal prolapse]] | |||
*[[Abdominal pain]] | *[[Abdominal pain]] | ||
*Weight loss | *[[Weight loss]] | ||
*[[Gynecomastia]] in males | |||
*Menstrual irregularities in females | |||
*[[Hematemesis]] | |||
*[[Fatigue]] | |||
<br> | |||
{| | |||
! colspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Percentage of symptom occurrence in Peutz-Jeghers syndrome | |||
|- | |||
! style="background:#7d7d7d; color: #FFFFFF;" align="center" + |Symptoms | |||
! style="background:#7d7d7d; color: #FFFFFF;" align="center" + |Percentage (%) | |||
|- | |||
| style="background:#DCDCDC;" align="center" + |Abnormal [[Hyperpigmentation|Pigmentation]] | |||
| style="background:#F5F5F5;" align="center" + |80 to 90 | |||
|- | |||
| style="background:#DCDCDC;" align="center" + |[[Gastrointestinal bleeding|GI Bleeding]] | |||
| style="background:#F5F5F5;" align="center" + |30 to 79 | |||
|- | |||
| style="background:#DCDCDC;" align="center" + |[[Abdominal pain|Abdominal Pain]] | |||
| style="background:#F5F5F5;" align="center" + |5 to 29 | |||
|} | |||
== References == | == References == | ||
{{reflist|2}} | {{reflist|2}} | ||
{{ | {{WH}} | ||
{{ | {{WS}} | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category: | [[Category:Surgery]] | ||
[[Category: | [[Category:Oncology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Pediatrics]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 16:50, 21 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
The hallmark of Peutz-Jeghers syndrome is hamatomatous polyps. A positive history of mucucutaneous hyperpigmentation and rectal bleeding is suggestive of Peutz-Jeghers syndrome. The most common symptoms of Peutz-Jeghers syndrome include abdominal pain, fatigue, and weight loss.
History and Symptoms
Individuals with Peutz-Jeghers syndrome may have positive history of:[1]
- Peutz-Jeghers syndrome in family
- Mucucutaneous hyperpigmentation of the oral mucosa
- Rectal bleeds
- Abdominal pain
- Fatigue
Symptoms of Peutz-Jeghers syndrome include the following:[1][2][3]
- Mucocutaneous hyperpigmentation (mouth, hands, and feet)
- Rectal bleeding
- Melena
- Rectal prolapse
- Abdominal pain
- Weight loss
- Gynecomastia in males
- Menstrual irregularities in females
- Hematemesis
- Fatigue
| Percentage of symptom occurrence in Peutz-Jeghers syndrome | |
|---|---|
| Symptoms | Percentage (%) |
| Abnormal Pigmentation | 80 to 90 |
| GI Bleeding | 30 to 79 |
| Abdominal Pain | 5 to 29 |
References
- ↑ 1.0 1.1 Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). "Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach". World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.
- ↑ Giardiello, F; Trimbath, J (2006). "Peutz-Jeghers Syndrome and Management Recommendations". Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.
- ↑ "Peutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".