Perindopril

Perindopril
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

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Black Box Warning

TITLE See full prescribing information for complete Boxed Warning. Condition Name: (Content)

Overview

Perindopril is an angiotensin converting enzyme inhibitor that is FDA approved for the {{{indicationType}}} of

Hypertension

• Dosing Information

• Use in Uncomplicated Hypertensive Patients:

• Initial dosage: 4 mg PO qd
• Maximun dosage: 16 mg/day PO
• Usually maintaining dosage: 4 mg-8 mg or 2 mg-4 mg PO bid

• Use in Elderly Patients

• Recommended initial dosage: 4 mg PO qd or 2 mg PO bid
• limited dosage: 8 mg/day(Dosages above 8 mg should be administered with careful blood pressure monitoring and dose titration)

Stable Coronary Artery Disease

• Dosing information

• Initial dosage: 4 mg PO qd for 2 weeks
• Maintainance dosage: 8 mg PO qd
• For seniors (age ≥ 70):

• Initial dosage for the 1st week: 2 mg PO qd
• Dosage for the 2nd week: 4 mg PO qd
• Maintaining dosage if tolerated: 8 mg PO qd

Dose Adjustment in Renal Impairment and Dialysis

• Dosing information

• Initial dosage: 2 mg/day
• Maximum dosage: 8 mg/day. There is a Black Box Warning for this drug as shown here. Common adverse reactions include

  Diabetes mellitus

• Dosing Information

• 2 mg/day or 4 mg/day

Prophylaxis treatment of Cerebrovascular accident

• Dosing information

• 4 mg/day

Duchenne muscular dystrophy

• Dosing information

• 2-4 mg/day

Myocardial infarction

• Dosing information

• 4 mg/day

Prophylaxis treatment of Paroxysmal atrial fibrillation

• Dosing information

• 2 mg.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition 1

• Dosing Information

(Dosage)

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition 1

• Developed by: (Organization)

• Class of Recommendation: (Class) (Link)

• Strength of Evidence: (Category A/B/C) (Link)

• Dosing Information/Recommendation

• (Dosage)

Non–Guideline-Supported Use

Condition 1

• Dosing Information

• There is limited information about Off-Label Non–Guideline-Supported Use of Perindopril in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition 1

• Dosing Information

(Dosage)

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition 1

• Developed by: (Organization)

• Class of Recommendation: (Class) (Link)

• Strength of Evidence: (Category A/B/C) (Link)

• Dosing Information/Recommendation

• (Dosage)

Non–Guideline-Supported Use

Condition 1

• Dosing Information

• There is limited information about Off-Label Non–Guideline-Supported Use of Perindopril in pediatric patients.

Contraindications

• Condition 1
• Condition 2
• Condition 3
• Condition 4
• Condition 5

Warnings

TITLE See full prescribing information for complete Boxed Warning. Condition Name: (Content)

Conidition 1

(Description)

Adverse Reactions

Clinical Trials Experience

Central Nervous System

(list/description of adverse reactions)

Cardiovascular

(list/description of adverse reactions)

Respiratory

(list/description of adverse reactions)

Gastrointestinal

(list/description of adverse reactions)

Hypersensitive Reactions

(list/description of adverse reactions)

Miscellaneous

(list/description of adverse reactions)

Postmarketing Experience

Central Nervous System

(list/description of adverse reactions)

Cardiovascular

(list/description of adverse reactions)

Respiratory

(list/description of adverse reactions)

Gastrointestinal

(list/description of adverse reactions)

Hypersensitive Reactions

(list/description of adverse reactions)

Miscellaneous

(list/description of adverse reactions)

Drug Interactions

• (Drug 1)

• (Description)

• (Drug 2)

• (Description)

• (Drug 3)

• (Description)

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Perindopril in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Perindopril in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Perindopril during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Perindopril in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Perindopril in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Perindopril in geriatric settings.

Gender

There is no FDA guidance on the use of Perindopril with respect to specific gender populations.

Race

There is no FDA guidance on the use of Perindopril with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Perindopril in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Perindopril in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Perindopril in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Perindopril in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Perindopril Administration in the drug label.

Monitoring

There is limited information regarding Perindopril Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Perindopril and IV administrations.

Overdosage

There is limited information regarding Perindopril overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Perindopril Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Perindopril Mechanism of Action in the drug label.

Structure

There is limited information regarding Perindopril Structure in the drug label.

Pharmacodynamics

There is limited information regarding Perindopril Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Perindopril Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Perindopril Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Perindopril Clinical Studies in the drug label.

How Supplied

There is limited information regarding Perindopril How Supplied in the drug label.

Storage

There is limited information regarding Perindopril Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Perindopril Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Perindopril interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Perindopril Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Perindopril Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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