PTPRT

Protein tyrosine phosphatase, receptor type, T
File:PBB Protein PTPRT image.jpg PDB rendering based on 2ooq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ooq​
Identifiers
Symbols	PTPRT ; KIAA0283; RPTPrho
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56924
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PTPRT 205948 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, T, also known as PTPRT, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Further reading

• Zhang X, Guo A, Yu J; et al. (2007). "Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4060–4. doi:10.1073/pnas.0611665104. PMID 17360477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee JW, Jeong EG, Lee SH; et al. (2007). "Mutational analysis of PTPRT phosphatase domains in common human cancers". APMIS. 115 (1): 47–51. doi:10.1111/j.1600-0463.2007.apm_554.x. PMID 17223850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu YF, Zhang HL, Cai T; et al. (2006). "The IA-2 interactome". Diabetologia. 48 (12): 2576–81. doi:10.1007/s00125-005-0037-y. PMID 16273344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Z, Shen D, Parsons DW; et al. (2004). "Mutational analysis of the tyrosine phosphatome in colorectal cancers". Science. 304 (5674): 1164–6. doi:10.1126/science.1096096. PMID 15155950.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Besco JA, Frostholm A, Popesco MC; et al. (2003). "Genomic organization and alternative splicing of the human and mouse RPTPrho genes: Correction". BMC Genomics. 2 (1): 5. PMID 11814386.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Besco JA, Frostholm A, Popesco MC; et al. (2003). "Genomic organization and alternative splicing of the human and mouse RPTPrho genes". BMC Genomics. 2 (1): 1. PMID 11423001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McAndrew PE, Frostholm A, White RA; et al. (1999). "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system". Brain Res. Mol. Brain Res. 56 (1–2): 9–21. PMID 9602027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McAndrew PE, Frostholm A, Evans JE; et al. (1998). "Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex". J. Comp. Neurol. 391 (4): 444–55. PMID 9486824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohara O, Nagase T, Ishikawa K; et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res. 4 (1): 53–9. PMID 9179496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)