PTPRN

Protein tyrosine phosphatase, receptor type, N
File:PBB Protein PTPRN image.jpg PDB rendering based on 2i1y.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2i1y​
Identifiers
Symbols	PTPRN ; FLJ16131; IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48142
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTPRN 204945 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, N, also known as PTPRN, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

Further reading

• Lan MS, Lu J, Goto Y, Notkins AL (1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol. 13 (5): 505–14. PMID 8024693.CS1 maint: Multiple names: authors list (link)
• Rabin DU, Pleasic SM, Shapiro JA; et al. (1994). "Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases". J. Immunol. 152 (6): 3183–8. PMID 8144912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Solimena M, Dirkx R, Hermel JM; et al. (1996). "ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules". EMBO J. 15 (9): 2102–14. PMID 8641276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van den Maagdenberg AM, Olde Weghuis D, Rijss J; et al. (1996). "Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker". Cytogenet. Cell Genet. 73 (1–2): 145–8. PMID 8646884.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cui L, Yu WP, DeAizpurua HJ; et al. (1996). "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes". J. Biol. Chem. 271 (40): 24817–23. PMID 8798755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie J, Zhang B, Lan MS, Notkins AL (1999). "Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN)". Genomics. 54 (2): 338–43. doi:10.1006/geno.1998.5583. PMID 9828138.CS1 maint: Multiple names: authors list (link)
• Ort T, Maksimova E, Dirkx R; et al. (2001). "The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells". Eur. J. Cell Biol. 79 (9): 621–30. PMID 11043403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park YS, Kawasaki E, Kelemen K; et al. (2001). "Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes". Diabetologia. 43 (10): 1293–301. PMID 11079748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berghs S, Aggujaro D, Dirkx R; et al. (2001). "betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system". J. Cell Biol. 151 (5): 985–1002. PMID 11086001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diez J, Park Y, Zeller M; et al. (2001). "Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen". Diabetes. 50 (4): 895–900. PMID 11289059.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ort T, Voronov S, Guo J; et al. (2001). "Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion". EMBO J. 20 (15): 4013–23. doi:10.1093/emboj/20.15.4013. PMID 11483505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mikulecký M, Michalková D (2002). "Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children". Biomed. Pharmacother. 55 Suppl 1: 106s–109s. PMID 11774856.
• Miao D, Yu L, Tiberti C; et al. (2002). "ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies". J. Autoimmun. 18 (2): 191–6. doi:10.1006/jaut.2001.0577. PMID 11908951.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawasaki E, Yamaguchi H, Hattori H; et al. (2002). "Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay". Ann. N. Y. Acad. Sci. 958: 241–6. PMID 12021115.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanjeevi CB, Das AK, Shtauvere-Brameus A (2002). "BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India". Ann. N. Y. Acad. Sci. 958: 293–6. PMID 12021127.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bearzatto M, Lampasona V, Belloni C, Bonifacio E (2004). "Fine mapping of diabetes-associated IA-2 specific autoantibodies". J. Autoimmun. 21 (4): 377–82. PMID 14624760.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trajkovski M, Mziaut H, Altkrüger A; et al. (2005). "Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells". J. Cell Biol. 167 (6): 1063–74. doi:10.1083/jcb.200408172. PMID 15596545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Takamura T, Nagai Y; et al. (2005). "Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody". Diabetes Res. Clin. Pract. 67 (1): 63–9. doi:10.1016/j.diabres.2004.05.004. PMID 15620435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)