PRKAR1B: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''cAMP-dependent protein kinase type I-beta regulatory subunit''' is an [[enzyme]] that in humans is encoded by the ''PRKAR1B'' [[gene]].<ref name="pmid1358799">{{cite journal | vauthors = Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A | title = Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7 | journal = Genomics | volume = 14 | issue = 1 | pages = 63–9 | date = Dec 1992 | pmid = 1358799 | pmc =  | doi = 10.1016/S0888-7543(05)80284-8 }}</ref><ref name="pmid3479018">{{cite journal | vauthors = Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T | title = Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis | journal = Am J Hum Genet | volume = 41 | issue = 5 | pages = 925–32 | date = Dec 1987 | pmid = 3479018 | pmc = 1684338 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5575| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Protein kinase, cAMP-dependent, regulatory, type I, beta
| HGNCid = 9390
| Symbol = PRKAR1B
| AltSymbols =; PRKAR1
| OMIM = 176911
| ECnumber = 
| Homologene = 37665
| MGIid = 97759
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0008603 |text = cAMP-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0030552 |text = cAMP binding}}
| Component = {{GNF_GO|id=GO:0005952 |text = cAMP-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5575
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001134041
    | Hs_RefseqmRNA = XM_001134041
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 19085
    | Mm_Ensembl = ENSMUSG00000025855
    | Mm_RefseqmRNA = NM_008923
    | Mm_RefseqProtein = NP_032949
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 139270948
    | Mm_GenLoc_end = 139383333
    | Mm_Uniprot = Q3TY04
  }}
}}
'''Protein kinase, cAMP-dependent, regulatory, type I, beta''', also known as '''PRKAR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5575| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mutations in '''PRKAR1B''' cause {{SWL|type=mutation_results_in|target=neurodegenerative disorder|label=neurodegenerative disorder}}.<ref>{{cite journal | vauthors = Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J | title = PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology | journal = Brain | volume = 137 | issue = Pt 5 | pages = 1361–73 | year = 2014 | pmid = 24722252 | doi = 10.1093/brain/awu067 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PRKAR1B has been shown to [[Protein-protein interaction|interact]] with [[AKAP1]]<ref name=pmid12634056>{{cite journal | vauthors = Carlson CR, Ruppelt A, Taskén K | title = A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system | language =  | journal = J. Mol. Biol. | volume = 327 | issue = 3 | pages = 609–18 | date = Mar 2003 | pmid = 12634056 | doi = 10.1016/S0022-2836(03)00093-7 }}</ref> and [[PRKAR1A]].<ref name=pmid12634056/><ref name=pmid8407966>{{cite journal | vauthors = Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V | title = Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes | language =  | journal = J. Biol. Chem. | volume = 268 | issue = 28 | pages = 21276–83 | date = Oct 1993 | pmid = 8407966 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L | title = Will diverse Tat interactions lead to novel antiretroviral drug targets? | journal = Current drug targets | volume = 7 | issue = 12 | pages = 1595–606 | year = 2007 | pmid = 17168834 | doi = 10.2174/138945006779025338 }}
| citations =
* {{cite journal | vauthors = Solberg R, Taskén K, Keiserud A, Jahnsen T | title = Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases | journal = Biochem. Biophys. Res. Commun. | volume = 176 | issue = 1 | pages = 166–72 | year = 1991 | pmid = 1708242 | doi = 10.1016/0006-291X(91)90904-L }}
*{{cite journal | author=Harrich D, McMillan N, Munoz L, ''et al.'' |title=Will diverse Tat interactions lead to novel antiretroviral drug targets? |journal=Current drug targets |volume=7 |issue= 12 |pages= 1595-606 |year= 2007 |pmid= 17168834 |doi= }}
* {{cite journal | vauthors = Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL | title = HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism | journal = J. Immunol. | volume = 145 | issue = 11 | pages = 3699–705 | year = 1991 | pmid = 1978848 | doi =  }}
*{{cite journal | author=Solberg R, Sistonen P, Träskelin AL, ''et al.'' |title=Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. |journal=Genomics |volume=14 |issue= 1 |pages= 63-9 |year= 1992 |pmid= 1358799 |doi= }}
* {{cite journal | vauthors = Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL | title = Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 14 | pages = 6676–80 | year = 1993 | pmid = 7688126 | pmc = 46995 | doi = 10.1073/pnas.90.14.6676 }}
*{{cite journal | author=Solberg R, Taskén K, Keiserud A, Jahnsen T |title=Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 1 |pages= 166-72 |year= 1991 |pmid= 1708242 |doi=  }}
* {{cite journal | vauthors = Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS | title = Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells | journal = Exp. Cell Res. | volume = 214 | issue = 2 | pages = 595–605 | year = 1994 | pmid = 7925653 | doi = 10.1006/excr.1994.1297 }}
*{{cite journal | author=Hofmann B, Nishanian P, Baldwin RL, ''et al.'' |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699-705 |year= 1991 |pmid= 1978848 |doi= }}
* {{cite journal | vauthors = Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL | title = HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro | journal = AIDS | volume = 8 | issue = 7 | pages = 1016–7 | year = 1994 | pmid = 7946090 | doi = 10.1097/00002030-199407000-00025 }}
*{{cite journal | author=Scambler P, Oyen O, Wainwright B, ''et al.'' |title=Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis. |journal=Am. J. Hum. Genet. |volume=41 |issue= 5 |pages= 925-32 |year= 1987 |pmid= 3479018 |doi= }}
* {{cite journal | vauthors = Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V | title = Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes | journal = J. Biol. Chem. | volume = 268 | issue = 28 | pages = 21276–83 | year = 1993 | pmid = 8407966 | doi = }}
*{{cite journal | author=Hofmann B, Nishanian P, Nguyen T, ''et al.'' |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676-80 |year= 1993 |pmid= 7688126 |doi= }}
* {{cite journal | vauthors = Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D | title = The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix | journal = J. Virol. | volume = 71 | issue = 6 | pages = 4372–7 | year = 1997 | pmid = 9151826 | pmc = 191654 | doi =  }}
*{{cite journal | author=Solberg R, Taskén K, Wen W, ''et al.'' |title=Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. |journal=Exp. Cell Res. |volume=214 |issue= 2 |pages= 595-605 |year= 1994 |pmid= 7925653 |doi= 10.1006/excr.1994.1297 }}
* {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22385–8 | year = 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}
*{{cite journal | author=Hofmann B, Nishanian P, Fan J, ''et al.'' |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016-7 |year= 1994 |pmid= 7946090 |doi=  }}
* {{cite journal | vauthors = Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F | title = Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways | journal = AIDS Res. Hum. Retroviruses | volume = 14 | issue = 10 | pages = 825–33 | year = 1998 | pmid = 9671211 | doi = 10.1089/aid.1998.14.825 }}
*{{cite journal | author=Taskén K, Skålhegg BS, Solberg R, ''et al.'' |title=Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 21276-83 |year= 1993 |pmid= 8407966 |doi= }}
* {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3–4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}
*{{cite journal | author=Swingler S, Gallay P, Camaur D, ''et al.'' |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372-7 |year= 1997 |pmid= 9151826 |doi= }}
* {{cite journal | vauthors = Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM | title = Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes | journal = J. Immunol. | volume = 162 | issue = 9 | pages = 5639–48 | year = 1999 | pmid = 10228048 | doi =  }}
*{{cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi= }}
* {{cite journal | vauthors = Adachi M, Lewis EJ | title = The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status | journal = J. Biol. Chem. | volume = 277 | issue = 25 | pages = 22915–24 | year = 2002 | pmid = 11943777 | doi = 10.1074/jbc.M201695200 }}
*{{cite journal | author=Zidovetzki R, Wang JL, Chen P, ''et al.'' |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825-33 |year= 1998 |pmid= 9671211 |doi=  }}
* {{cite journal | vauthors = Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S | title = Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology | journal = Mol. Cell. Biol. | volume = 22 | issue = 13 | pages = 4690–701 | year = 2002 | pmid = 12052877 | pmc = 133892 | doi = 10.1128/MCB.22.13.4690-4701.2002 }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi= }}
* {{cite journal | vauthors = Nguyen DT, Rovira II, Finkel T | title = Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A | journal = FEBS Lett. | volume = 521 | issue = 1–3 | pages = 170–4 | year = 2002 | pmid = 12067711 | doi = 10.1016/S0014-5793(02)02868-5 }}
*{{cite journal | author=Laxminarayana D, Khan IU, Mishra N, ''et al.'' |title=Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes. |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5639-48 |year= 1999 |pmid= 10228048 |doi= }}
* {{cite journal | vauthors = Mucignat-Caretta C, Caretta A | title = Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain | journal = J. Neurocytol. | volume = 30 | issue = 11 | pages = 885–94 | year = 2003 | pmid = 12373096 | doi = 10.1023/A:1020613132648 }}
*{{cite journal | author=Adachi M, Lewis EJ |title=The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22915-24 |year= 2002 |pmid= 11943777 |doi= 10.1074/jbc.M201695200 }}
* {{cite journal | vauthors = Carlson CR, Ruppelt A, Taskén K | title = A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system | journal = J. Mol. Biol. | volume = 327 | issue = 3 | pages = 609–18 | year = 2003 | pmid = 12634056 | doi = 10.1016/S0022-2836(03)00093-7 }}
*{{cite journal | author=Oliver CJ, Terry-Lorenzo RT, Elliott E, ''et al.'' |title=Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4690-701 |year= 2002 |pmid= 12052877 |doi= }}
*{{cite journal | author=Nguyen DT, Rovira II, Finkel T |title=Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 170-4 |year= 2002 |pmid= 12067711 |doi= }}
*{{cite journal  | author=Mucignat-Caretta C, Caretta A |title=Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain. |journal=J. Neurocytol. |volume=30 |issue= 11 |pages= 885-94 |year= 2003 |pmid= 12373096 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Carlson CR, Ruppelt A, Taskén K |title=A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. |journal=J. Mol. Biol. |volume=327 |issue= 3 |pages= 609-18 |year= 2003 |pmid= 12634056 |doi=  }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
 
[[Category:Genes on human chromosome 7]]

Latest revision as of 18:41, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.[1][2][3]

Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder .[4]

Interactions

PRKAR1B has been shown to interact with AKAP1[5] and PRKAR1A.[5][6]

References

  1. ↑ Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
  2. ↑ Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018.
  3. ↑ "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".
  4. ↑ Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. PMID 24722252.
  5. ↑ 5.0 5.1 Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
  6. ↑ Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. PMID 8407966.

Further reading


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