PRKAB1

Protein kinase, AMP-activated, beta 1 non-catalytic subunit
File:PBB Protein PRKAB1 image.jpg PDB rendering based on 1z0m.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1z0m​, 1z0n​
Identifiers
Symbols	PRKAB1 ; AMPK; HAMPKb; MGC17785
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38160
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PRKAB1 201835 s at tn.png
File:PBB GE PRKAB1 201834 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein kinase, AMP-activated, beta 1 non-catalytic subunit, also known as PRKAB1, is a human gene.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Further reading

• Carling D (2004). "The AMP-activated protein kinase cascade--a unifying system for energy control". Trends Biochem. Sci. 29 (1): 18–24. PMID 14729328.
• Stapleton D, Mitchelhill KI, Gao G; et al. (1996). "Mammalian AMP-activated protein kinase subfamily". J. Biol. Chem. 271 (2): 611–4. PMID 8557660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gao G, Fernandez CS, Stapleton D; et al. (1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". J. Biol. Chem. 271 (15): 8675–81. PMID 8621499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woods A, Cheung PC, Smith FC; et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro". J. Biol. Chem. 271 (17): 10282–90. PMID 8626596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dyck JR, Gao G, Widmer J; et al. (1996). "Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits". J. Biol. Chem. 271 (30): 17798–803. PMID 8663446.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stapleton D, Woollatt E, Mitchelhill KI; et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location". FEBS Lett. 409 (3): 452–6. PMID 9224708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitchelhill KI, Michell BJ, House CM; et al. (1997). "Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit". J. Biol. Chem. 272 (39): 24475–9. PMID 9305909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thornton C, Snowden MA, Carling D (1998). "Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle". J. Biol. Chem. 273 (20): 12443–50. PMID 9575201.CS1 maint: Multiple names: authors list (link)
• Cheung PC, Salt IP, Davies SP; et al. (2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. 346 Pt 3: 659–69. PMID 10698692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• da Silva Xavier G, Leclerc I, Salt IP; et al. (2000). "Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4023–8. PMID 10760274.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemieux K, Konrad D, Klip A, Marette A (2003). "The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle". FASEB J. 17 (12): 1658–65. doi:10.1096/fj.02-1125com. PMID 12958172.CS1 maint: Multiple names: authors list (link)
• Landree LE, Hanlon AL, Strong DW; et al. (2004). "C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism". J. Biol. Chem. 279 (5): 3817–27. doi:10.1074/jbc.M310991200. PMID 14615481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoki K, Zhu T, Guan KL (2004). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. 115 (5): 577–90. PMID 14651849.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersson U, Filipsson K, Abbott CR; et al. (2004). "AMP-activated protein kinase plays a role in the control of food intake". J. Biol. Chem. 279 (13): 12005–8. doi:10.1074/jbc.C300557200. PMID 14742438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pilon G, Dallaire P, Marette A (2004). "Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs". J. Biol. Chem. 279 (20): 20767–74. doi:10.1074/jbc.M401390200. PMID 14985344.CS1 maint: Multiple names: authors list (link)
• Shaw RJ, Kosmatka M, Bardeesy N; et al. (2004). "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3329–35. doi:10.1073/pnas.0308061100. PMID 14985505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim EK, Miller I, Aja S; et al. (2004). "C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase". J. Biol. Chem. 279 (19): 19970–6. doi:10.1074/jbc.M402165200. PMID 15028725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)