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Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14 , is an enzyme that in humans is encoded by the PPT2 gene .[1] [2] [3]
Function This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins.[1]
References Further reading
Gupta P, Soyombo AA, Atashband A, et al. (2001). "Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice" . Proc. Natl. Acad. Sci. U.S.A . 98 (24): 13566–71. doi :10.1073/pnas.251485198 . PMC 61081 PMID 11717424 . Aguado B, Campbell RD (1999). "Characterization of a human MHC class III region gene product with S-thioesterase activity" . Biochem. J . 341 ( Pt 3) (Pt 3): 679–89. PMC 1220406 PMID 10417332 . Simpson JC, Wellenreuther R, Poustka A, et al. (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Hancock DB, Eijgelsheim M, Wilk JB, et al. (2010). "Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function" . Nat. Genet . 42 (1): 45–52. doi :10.1038/ng.500 . PMC 2832852 PMID 20010835 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Calero G, Gupta P, Nonato MC, et al. (2003). "The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2". J. Biol. Chem . 278 (39): 37957–64. doi :10.1074/jbc.M301225200 . PMID 12855696 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature . 425 (6960): 805–11. doi :10.1038/nature02055 . PMID 14574404 . Barcellos LF, May SL, Ramsay PP, et al. (2009). Roopenian DC, ed. "High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions" . PLoS Genet . 5 (10): e1000696. doi :10.1371/journal.pgen.1000696 . PMC 2758598 PMID 19851445 . McKinnon E, Morahan G, Nolan D, et al. (2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach" . Diabetes Obes Metab . 11 (Suppl 1): 92–100. doi :10.1111/j.1463-1326.2008.01009.x . PMC 2755510 PMID 19143821 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Xie T, Rowen L, Aguado B, et al. (2003). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse" . Genome Res . 13 (12): 2621–36. doi :10.1101/gr.1736803 . PMC 403804 PMID 14656967 . Hartley JL, Temple GF, Brasch MA (2000). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance" . Genome Biol . 5 (2): R8. doi :10.1186/gb-2004-5-2-r8 . PMC 395752 PMID 14759258 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
Activity Regulation Classification Kinetics Types
