PPP2R3A

Protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha
Identifiers
Symbols	PPP2R3A ; PPP2R3; PR130; PR72
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20595
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PPP2R3A 209632 at tn.png
File:PBB GE PPP2R3A 207749 s at tn.png
File:PBB GE PPP2R3A 209633 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha, also known as PPP2R3A, is a human gene.

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B family. The B family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochem. Pharmacol. 60 (8): 1225–35. PMID 11007961.
• Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. PMID 15638722.
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
• Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.CS1 maint: Multiple names: authors list (link)
• Mayer RE, Hendrix P, Cron P; et al. (1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. PMID 1849734.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hendrix P, Mayer-Jackel RE, Cron P; et al. (1993). "Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing". J. Biol. Chem. 268 (20): 15267–76. PMID 8392071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.CS1 maint: Multiple names: authors list (link)
• Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". J. Virol. 73 (1): 839–42. PMID 9847399.CS1 maint: Multiple names: authors list (link)
• Voorhoeve PM, Hijmans EM, Bernards R (1999). "Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein". Oncogene. 18 (2): 515–24. doi:10.1038/sj.onc.1202316. PMID 9927208.CS1 maint: Multiple names: authors list (link)
• Takahashi M, Shibata H, Shimakawa M; et al. (1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". J. Biol. Chem. 274 (24): 17267–74. PMID 10358086.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan Z, Fedorov SA, Mumby MC, Williams RS (2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Mol. Cell. Biol. 20 (3): 1021–9. PMID 10629059.CS1 maint: Multiple names: authors list (link)
• Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.CS1 maint: Multiple names: authors list (link)
• Lubert EJ, Hong Y, Sarge KD (2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5". J. Biol. Chem. 276 (42): 38582–7. doi:10.1074/jbc.M106906200. PMID 11504734.CS1 maint: Multiple names: authors list (link)
• Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMID 12110603.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)