PPP1R12A: Difference between revisions

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{{Infobox_gene}}
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'''Protein phosphatase 1 regulatory subunit 12A''' is an [[enzyme]] that in humans is encoded by the ''PPP1R12A'' [[gene]].<ref name="pmid9286714">{{cite journal |vauthors=Takahashi N, Ito M, Tanaka J, Nakano T, Kaibuchi K, Odai H, Takemura K | title = Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21 | journal = Genomics | volume = 44 | issue = 1 | pages = 150–2 |date=Nov 1997 | pmid = 9286714 | pmc =  | doi = 10.1006/geno.1997.4859 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4659| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPP1R12A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s70.
| PDB = {{PDB2|1s70}}
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 12A
| HGNCid = 7618
| Symbol = PPP1R12A
| AltSymbols =; MBS; MGC133042; MYPT1
| OMIM = 602021
| ECnumber =
| Homologene = 1855
| MGIid = 1309528
  | GeneAtlas_image1 = PBB_GE_PPP1R12A_201603_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP1R12A_201602_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PPP1R12A_201604_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}  
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006937 |text = regulation of muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4659
    | Hs_Ensembl = ENSG00000058272
    | Hs_RefseqProtein = NP_002471
    | Hs_RefseqmRNA = NM_002480
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 78692317
    | Hs_GenLoc_end = 78853366
    | Hs_Uniprot = O14974
    | Mm_EntrezGene = 17931
    | Mm_Ensembl = ENSMUSG00000019907
    | Mm_RefseqmRNA = XM_001004092
    | Mm_RefseqProtein = XP_001004092
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 107566510
    | Mm_GenLoc_end = 107681685
    | Mm_Uniprot = Q05A74
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 12A''', also known as '''PPP1R12A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4659| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4659| accessdate = }}</ref>
| summary_text = Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle <ref>{{cite news|title=Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697|author1=Michael P. Walsh|author2=et all|url=http://biosupport.licor.com/docs/2005/BJ20050237.pdf|deadurl=yes|archiveurl=https://web.archive.org/web/20110713204304/http://biosupport.licor.com/docs/2005/BJ20050237.pdf|archivedate=2011-07-13|df=}}</ref> and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.<ref name="entrez"/>
}}
}}
==Interactions==
PPP1R12A has been shown to [[Protein-protein interaction|interact]] with [[Interleukin 16]].<ref name=pmid12923170>{{cite journal |last=Bannert |first=Norbert |authorlink= |author2=Vollhardt Karin |author3=Asomuddinov Bakhtier |author4=Haag Marion |author5=König Herbert |author6=Norley Stephen |author7=Kurth Reinhard  |date=Oct 2003 |title=PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits |journal=J. Biol. Chem. |volume=278 |issue=43 |pages=42190–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12923170 |doi = 10.1074/jbc.M306669200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Somlyo AP, Wu X, Walker LA, Somlyo AV |title=Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=134 |issue=  |pages= 201-34 |year= 1999 |pmid= 10087910 |doi=  }}
*{{cite journal  |vauthors=Somlyo AP, Wu X, Walker LA, Somlyo AV |title=Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=134 |issue=  |pages= 201–34 |year= 1999 |pmid= 10087910 |doi=  10.1007/3-540-64753-8_5}}
*{{cite journal  | author=Ziter FA, Wiser WC, Robinson A |title=Three-generation pedigree of a Möbius syndrome variant with chromosome translocation. |journal=Arch. Neurol. |volume=34 |issue= 7 |pages= 437-42 |year= 1977 |pmid= 880069 |doi=  }}
*{{cite journal  |vauthors=Ziter FA, Wiser WC, Robinson A |title=Three-generation pedigree of a Möbius syndrome variant with chromosome translocation. |journal=Arch. Neurol. |volume=34 |issue= 7 |pages= 437–42 |year= 1977 |pmid= 880069 |doi=  10.1001/archneur.1977.00500190071011}}
*{{cite journal  | author=Slee JJ, Smart RD, Viljoen DL |title=Deletion of chromosome 13 in Moebius syndrome. |journal=J. Med. Genet. |volume=28 |issue= 6 |pages= 413-4 |year= 1991 |pmid= 1870098 |doi=  }}
*{{cite journal  |vauthors=Slee JJ, Smart RD, Viljoen DL |title=Deletion of chromosome 13 in Moebius syndrome. |journal=J. Med. Genet. |volume=28 |issue= 6 |pages= 413–4 |year= 1991 |pmid= 1870098 |doi=10.1136/jmg.28.6.413  | pmc=1016909 }}
*{{cite journal | author=Kimura K, Ito M, Amano M, ''et al.'' |title=Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) |journal=Science |volume=273 |issue= 5272 |pages= 245-8 |year= 1996 |pmid= 8662509 |doi=  }}
*{{cite journal   |vauthors=Kimura K, Ito M, Amano M, etal |title=Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) |journal=Science |volume=273 |issue= 5272 |pages= 245–8 |year= 1996 |pmid= 8662509 |doi=10.1126/science.273.5272.245 |bibcode=1996Sci...273..245K }}
*{{cite journal | author=Ito M, Feng J, Tsujino S, ''et al.'' |title=Interaction of smooth muscle myosin phosphatase with phospholipids. |journal=Biochemistry |volume=36 |issue= 24 |pages= 7607-14 |year= 1997 |pmid= 9200713 |doi= 10.1021/bi9702647 }}
*{{cite journal   |vauthors=Ito M, Feng J, Tsujino S, etal |title=Interaction of smooth muscle myosin phosphatase with phospholipids. |journal=Biochemistry |volume=36 |issue= 24 |pages= 7607–14 |year= 1997 |pmid= 9200713 |doi= 10.1021/bi9702647 }}
*{{cite journal | author=Takahashi N, Ito M, Tanaka J, ''et al.'' |title=Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21. |journal=Genomics |volume=44 |issue= 1 |pages= 150-2 |year= 1997 |pmid= 9286714 |doi= 10.1006/geno.1997.4859 }}
*{{cite journal   |vauthors=Nakai K, Suzuki Y, Kihira H, etal |title=Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation. |journal=Blood |volume=90 |issue= 10 |pages= 3936–42 |year= 1997 |pmid= 9354661 |doi=  }}
*{{cite journal  | author=Nakai K, Suzuki Y, Kihira H, ''et al.'' |title=Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation. |journal=Blood |volume=90 |issue= 10 |pages= 3936-42 |year= 1997 |pmid= 9354661 |doi=  }}
*{{cite journal  | author=Somlyo AP |title=Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser. |journal=J. Physiol. |volume=516 |issue= 3|pages= 630 |year= 1999 |pmid= 10200412 |doi=10.1111/j.1469-7793.1999.0630u.x  | pmc=2269296 }}
*{{cite journal  | author=Somlyo AP |title=Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser. |journal=J. Physiol. (Lond.) |volume=516 ( Pt 3) |issue= |pages= 630 |year= 1999 |pmid= 10200412 |doi=  }}
*{{cite journal   |vauthors=Surks HK, Mochizuki N, Kasai Y, etal |title=Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. |journal=Science |volume=286 |issue= 5444 |pages= 1583–7 |year= 1999 |pmid= 10567269 |doi=10.1126/science.286.5444.1583 }}
*{{cite journal | author=Surks HK, Mochizuki N, Kasai Y, ''et al.'' |title=Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. |journal=Science |volume=286 |issue= 5444 |pages= 1583-7 |year= 1999 |pmid= 10567269 |doi=  }}
*{{cite journal   |vauthors=Feng J, Ito M, Ichikawa K, etal |title=Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 37385–90 |year= 2000 |pmid= 10601309 |doi=10.1074/jbc.274.52.37385 }}
*{{cite journal | author=Feng J, Ito M, Ichikawa K, ''et al.'' |title=Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 37385-90 |year= 2000 |pmid= 10601309 |doi=  }}
*{{cite journal   |vauthors=Arimura T, Suematsu N, Zhou YB, etal |title=Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6073–82 |year= 2001 |pmid= 11067852 |doi= 10.1074/jbc.M008566200 }}
*{{cite journal | author=Arimura T, Suematsu N, Zhou YB, ''et al.'' |title=Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6073-82 |year= 2001 |pmid= 11067852 |doi= 10.1074/jbc.M008566200 }}
*{{cite journal   |vauthors=Sebbagh M, Renvoizé C, Hamelin J, etal |title=Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. |journal=Nat. Cell Biol. |volume=3 |issue= 4 |pages= 346–52 |year= 2001 |pmid= 11283607 |doi= 10.1038/35070019 }}
*{{cite journal | author=Sebbagh M, Renvoizé C, Hamelin J, ''et al.'' |title=Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. |journal=Nat. Cell Biol. |volume=3 |issue= 4 |pages= 346-52 |year= 2001 |pmid= 11283607 |doi= 10.1038/35070019 }}
*{{cite journal   |vauthors=Murányi A, Zhang R, Liu F, etal |title=Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. |journal=FEBS Lett. |volume=493 |issue= 2-3 |pages= 80–4 |year= 2001 |pmid= 11287000 |doi=10.1016/S0014-5793(01)02283-9 }}
*{{cite journal | author=Murányi A, Zhang R, Liu F, ''et al.'' |title=Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. |journal=FEBS Lett. |volume=493 |issue= 2-3 |pages= 80-4 |year= 2001 |pmid= 11287000 |doi=  }}
*{{cite journal   |vauthors=Machida H, Ito M, Okamoto R, etal |title=Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 3 |pages= 424–9 |year= 2001 |pmid= 11342221 |doi=  10.1016/s0167-4781(00)00285-2}}
*{{cite journal | author=Machida H, Ito M, Okamoto R, ''et al.'' |title=Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 3 |pages= 424-9 |year= 2001 |pmid= 11342221 |doi=  }}
*{{cite journal   |vauthors=Kiss E, Murányi A, Csortos C, etal |title=Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton. |journal=Biochem. J. |volume=365 |issue= Pt 1 |pages= 79–87 |year= 2002 |pmid= 11931630 |doi= 10.1042/BJ20011295 | pmc=1222641 }}
*{{cite journal | author=Kiss E, Murányi A, Csortos C, ''et al.'' |title=Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton. |journal=Biochem. J. |volume=365 |issue= Pt 1 |pages= 79-87 |year= 2002 |pmid= 11931630 |doi= 10.1042/BJ20011295 }}
*{{cite journal   |vauthors=Velasco G, Armstrong C, Morrice N, etal |title=Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 101–4 |year= 2002 |pmid= 12220642 |doi=10.1016/S0014-5793(02)03175-7 }}
*{{cite journal | author=Velasco G, Armstrong C, Morrice N, ''et al.'' |title=Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 101-4 |year= 2002 |pmid= 12220642 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Kitazawa T, Eto M, Woodsome TP, Khalequzzaman M |title=Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. |journal=J. Physiol. |volume=546 |issue= Pt 3 |pages= 879–89 |year= 2003 |pmid= 12563012 |doi=10.1113/jphysiol.2002.029306  | pmc=2342583 }}
*{{cite journal  | author=Kitazawa T, Eto M, Woodsome TP, Khalequzzaman M |title=Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. |journal=J. Physiol. (Lond.) |volume=546 |issue= Pt 3 |pages= 879-89 |year= 2003 |pmid= 12563012 |doi=  }}
*{{cite journal   |vauthors=Seko T, Ito M, Kureishi Y, etal |title=Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. |journal=Circ. Res. |volume=92 |issue= 4 |pages= 411–8 |year= 2003 |pmid= 12600888 |doi= 10.1161/01.RES.0000059987.90200.44 }}
*{{cite journal | author=Seko T, Ito M, Kureishi Y, ''et al.'' |title=Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. |journal=Circ. Res. |volume=92 |issue= 4 |pages= 411-8 |year= 2003 |pmid= 12600888 |doi= 10.1161/01.RES.0000059987.90200.44 }}
}}
}}
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{{protein-stub}}
==External links==
{{WikiDoc Sources}}
*[https://web.archive.org/web/20110722013425/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=4659 PPP1R12A] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
 
{{PDB Gallery|geneid=4659}}
 
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{{gene-12-stub}}

Latest revision as of 19:48, 25 June 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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View/Edit Human

Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.[1][2]

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle [3] and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.[2]

Interactions

PPP1R12A has been shown to interact with Interleukin 16.[4]

References

  1. ↑ Takahashi N, Ito M, Tanaka J, Nakano T, Kaibuchi K, Odai H, Takemura K (Nov 1997). "Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21". Genomics. 44 (1): 150–2. doi:10.1006/geno.1997.4859. PMID 9286714.
  2. ↑ 2.0 2.1 "Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A".
  3. ↑ Michael P. Walsh; et all. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). Archived from the original (PDF) on 2011-07-13.
  4. ↑ Bannert, Norbert; Vollhardt Karin; Asomuddinov Bakhtier; Haag Marion; König Herbert; Norley Stephen; Kurth Reinhard (Oct 2003). "PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits". J. Biol. Chem. United States. 278 (43): 42190–9. doi:10.1074/jbc.M306669200. ISSN 0021-9258. PMID 12923170.

Further reading

External links



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