PIAS3

Protein inhibitor of activated STAT, 3
Identifiers
Symbols	PIAS3 ; FLJ14651; ZMIZ5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4447
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIAS3 203035 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein inhibitor of activated STAT, 3, also known as PIAS3, is a human gene.

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.

Further reading

• Chung CD, Liao J, Liu B; et al. (1997). "Specific inhibition of Stat3 signal transduction by PIAS3". Science. 278 (5344): 1803–5. PMID 9388184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueki N, Seki N, Yano K; et al. (1999). "Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)". J. Hum. Genet. 44 (3): 193–6. PMID 10319586.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rödel B, Tavassoli K, Karsunky H; et al. (2000). "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845–55. doi:10.1093/emboj/19.21.5845. PMID 11060035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Junicho A, Matsuda T, Yamamoto T; et al. (2001). "Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells". Biochem. Biophys. Res. Commun. 278 (1): 9–13. doi:10.1006/bbrc.2000.3753. PMID 11071847.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kotaja N, Aittomäki S, Silvennoinen O; et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. 14 (12): 1986–2000. PMID 11117529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zentner MD, Lin HH, Deng HT; et al. (2001). "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells". J. Biol. Chem. 276 (32): 29805–14. doi:10.1074/jbc.M103153200. PMID 11390395.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang LH, Yang XY, Mihalic K; et al. (2001). "Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3". J. Biol. Chem. 276 (34): 31839–44. doi:10.1074/jbc.M105185200. PMID 11429412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levy C, Nechushtan H, Razin E (2002). "A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor". J. Biol. Chem. 277 (3): 1962–6. doi:10.1074/jbc.M109236200. PMID 11709556.CS1 maint: Multiple names: authors list (link)
• Jiménez-Lara AM, Heine MJ, Gronemeyer H (2002). "PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2". FEBS Lett. 526 (1–3): 142–6. PMID 12208521.CS1 maint: Multiple names: authors list (link)
• Nakagawa K, Yokosawa H (2002). "PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1". FEBS Lett. 530 (1–3): 204–8. PMID 12387893.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamamoto T, Sato N, Sekine Y; et al. (2003). "Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor". Biochem. Biophys. Res. Commun. 306 (2): 610–5. PMID 12804609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Di Y, Li J, Zhang Y; et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713–8. PMID 12869526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheng J, Zhang D, Zhou C, Marasco WA (2004). "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells". Leuk. Res. 28 (1): 71–82. PMID 14630083.CS1 maint: Multiple names: authors list (link)
• Long J, Wang G, Matsuura I; et al. (2004). "Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)". Proc. Natl. Acad. Sci. U.S.A. 101 (1): 99–104. doi:10.1073/pnas.0307598100. PMID 14691252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nojiri S, Joh T, Miura Y; et al. (2004). "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3". Biochem. Biophys. Res. Commun. 314 (1): 97–103. PMID 14715251.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Banerjee S (2004). "Differential PIAS3 expression in human malignancy". Oncol. Rep. 11 (6): 1319–24. PMID 15138572.
• Jang HD, Yoon K, Shin YJ; et al. (2004). "PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit". J. Biol. Chem. 279 (23): 24873–80. doi:10.1074/jbc.M313018200. PMID 15140884.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)