PFN2

Profilin 2
File:PBB Protein PFN2 image.jpg PDB rendering based on 1d1j.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1d1j​
Identifiers
Symbols	PFN2 ; D3S1319E; PFL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1974
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PFN2 204992 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Profilin 2, also known as PFN2, is a human gene.

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

Further reading

• Qualmann B, Kessels MM (2003). "Endocytosis and the cytoskeleton". Int. Rev. Cytol. 220: 93–144. PMID 12224553.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Kwiatkowski DJ, Bruns GA (1988). "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis". J. Biol. Chem. 263 (12): 5910–5. PMID 3356709.
• Reinhard M, Giehl K, Abel K; et al. (1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins". EMBO J. 14 (8): 1583–9. PMID 7737110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gieselmann R, Kwiatkowski DJ, Janmey PA, Witke W (1995). "Distinct biochemical characteristics of the two human profilin isoforms". Eur. J. Biochem. 229 (3): 621–8. PMID 7758455.CS1 maint: Multiple names: authors list (link)
• Honoré B, Madsen P, Andersen AH, Leffers H (1993). "Cloning and expression of a novel human profilin variant, profilin II". FEBS Lett. 330 (2): 151–5. PMID 8365484.CS1 maint: Multiple names: authors list (link)
• Naylor SL, Carritt B, Boileau C; et al. (1996). "Report of the sixth international workshop on human chromosome 3 mapping 1995". Cytogenet. Cell Genet. 72 (4): 255–70. PMID 8641130.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joensuu T, Blanco G, Pakarinen L; et al. (1997). "Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region". Genomics. 38 (3): 255–63. PMID 8975700.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Witke W, Podtelejnikov AV, Di Nardo A; et al. (1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". EMBO J. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMID 9463375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nodelman IM, Bowman GD, Lindberg U, Schutt CE (2000). "X-ray structure determination of human profilin II: A comparative structural analysis of human profilins". J. Mol. Biol. 294 (5): 1271–85. doi:10.1006/jmbi.1999.3318. PMID 10600384.CS1 maint: Multiple names: authors list (link)
• Harbeck B, Hüttelmaier S, Schluter K; et al. (2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. 275 (40): 30817–25. doi:10.1074/jbc.M005066200. PMID 10882740.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lambrechts A, Kwiatkowski AV, Lanier LM; et al. (2000). "cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains". J. Biol. Chem. 275 (46): 36143–51. doi:10.1074/jbc.M006274200. PMID 10945997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lambrechts A, Braun A, Jonckheere V; et al. (2000). "Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties". Mol. Cell. Biol. 20 (21): 8209–19. PMID 11027290.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tojo H, Kaieda I, Hattori H; et al. (2004). "The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa". Mol. Endocrinol. 17 (7): 1216–29. doi:10.1210/me.2003-0056. PMID 12677009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Da Silva JS, Medina M, Zuliani C; et al. (2003). "RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability". J. Cell Biol. 162 (7): 1267–79. doi:10.1083/jcb.200304021. PMID 14517206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goehler H, Lalowski M, Stelzl U; et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lederer M, Jockusch BM, Rothkegel M (2005). "Profilin regulates the activity of p42POP, a novel Myb-related transcription factor". J. Cell. Sci. 118 (Pt 2): 331–41. doi:10.1242/jcs.01618. PMID 15615774.CS1 maint: Multiple names: authors list (link)