PEX14: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
{{Pfam_box
| update_page = yes
| Symbol = Pex14_N
| require_manual_inspection = no
| Name = Peroxisomal membrane anchor protein (Pex14p) conserved region
| update_protein_box = yes
| Pfam = PF04695
| update_summary = yes
| InterPro = IPR006785
| update_citations = yes
}}
}}
'''Peroxisomal membrane protein PEX14''' is a [[protein]] that in humans is encoded by the ''PEX14'' [[gene]].<ref name="pmid9653144">{{cite journal | vauthors = Fransen M, Terlecky SR, Subramani S | title = Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 8087–92 | date = Jul 1998 | pmid = 9653144 | pmc = 20933 | doi = 10.1073/pnas.95.14.8087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEX14 peroxisomal biogenesis factor 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5195| accessdate = }}</ref>


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
 
| image =
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.<ref name="entrez" />
| image_source =
 
| PDB =  
== Interactions ==
| Name = Peroxisomal biogenesis factor 14
 
| HGNCid = 8856
PEX14 has been shown to [[Protein-protein interaction|interact]] with
| Symbol = PEX14
* [[PEX5]],<ref name="pmid11865044">{{cite journal | vauthors = Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y | title = Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import | journal = Molecular and Cellular Biology | volume = 22 | issue = 6 | pages = 1639–55 | date = Mar 2002 | pmid = 11865044 | pmc = 135613 | doi = 10.1128/MCB.22.6.1639-1655.2002 }}</ref><ref name="pmid10837480">{{cite journal | vauthors = Okumoto K, Abe I, Fujiki Y | title = Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p | journal = The Journal of Biological Chemistry | volume = 275 | issue = 33 | pages = 25700–10 | date = Aug 2000 | pmid = 10837480 | doi = 10.1074/jbc.M003303200 }}</ref><ref name="pmid10212238">{{cite journal | vauthors = Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y | title = The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12593–604 | date = Apr 1999 | pmid = 10212238 | doi = 10.1074/jbc.274.18.12593 }}</ref><ref name="pmid17461798">{{cite journal | vauthors = Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H | title = The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies | journal = Traffic | volume = 8 | issue = 6 | pages = 687–701 | date = Jun 2007 | pmid = 17461798 | doi = 10.1111/j.1600-0854.2007.00560.x }}</ref>
| AltSymbols =; MGC12767; NAPP2; Pex14p; dJ734G22.2
* [[PEX7]],<ref name=pmid17461798/> and
| OMIM = 601791
* [[PEX13]].<ref name="pmid11865044"/>
| ECnumber =
| Homologene = 37936
| MGIid = 1927868
| GeneAtlas_image1 = PBB_GE_PEX14_33760_at_tn.png
| GeneAtlas_image2 = PBB_GE_PEX14_203503_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005777 |text = peroxisome}} {{GNF_GO|id=GO:0005779 |text = integral to peroxisomal membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5195
    | Hs_Ensembl = ENSG00000142655
    | Hs_RefseqProtein = NP_004556
    | Hs_RefseqmRNA = NM_004565
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 10457531
    | Hs_GenLoc_end = 10613402
    | Hs_Uniprot = O75381
    | Mm_EntrezGene = 56273
    | Mm_Ensembl = ENSMUSG00000028975
    | Mm_RefseqmRNA = XM_622907
    | Mm_RefseqProtein = XP_622907
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 147804335
    | Mm_GenLoc_end = 147943676
    | Mm_Uniprot = Q9QX52
  }}
}}
'''Peroxisomal biogenesis factor 14''', also known as '''PEX14''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PEX14 peroxisomal biogenesis factor 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5195| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.<ref name="entrez">{{cite web | title = Entrez Gene: PEX14 peroxisomal biogenesis factor 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5195| accessdate = }}</ref>
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH | title = Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways | journal = Cell | volume = 89 | issue = 1 | pages = 83–92 | date = Apr 1997 | pmid = 9094717 | doi = 10.1016/S0092-8674(00)80185-3 }}  
| citations =
* {{cite journal | vauthors = Huhse B, Rehling P, Albertini M, Blank L, Meller K, Kunau WH | title = Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery | journal = The Journal of Cell Biology | volume = 140 | issue = 1 | pages = 49–60 | date = Jan 1998 | pmid = 9425153 | pmc = 2132588 | doi = 10.1083/jcb.140.1.49 }}
*{{cite journal | author=Albertini M, Rehling P, Erdmann R, ''et al.'' |title=Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. |journal=Cell |volume=89 |issue= 1 |pages= 83-92 |year= 1997 |pmid= 9094717 |doi= }}
* {{cite journal | vauthors = Will GK, Soukupova M, Hong X, Erdmann KS, Kiel JA, Dodt G, Kunau WH, Erdmann R | title = Identification and characterization of the human orthologue of yeast Pex14p | journal = Molecular and Cellular Biology | volume = 19 | issue = 3 | pages = 2265–77 | date = Mar 1999 | pmid = 10022913 | pmc = 84019 | doi =  10.1128/mcb.19.3.2265}}
*{{cite journal | author=Huhse B, Rehling P, Albertini M, ''et al.'' |title=Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. |journal=J. Cell Biol. |volume=140 |issue= 1 |pages= 49-60 |year= 1998 |pmid= 9425153 |doi= }}
* {{cite journal | vauthors = Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R | title = Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes | journal = The Journal of Cell Biology | volume = 144 | issue = 6 | pages = 1151–62 | date = Mar 1999 | pmid = 10087260 | pmc = 2150583 | doi = 10.1083/jcb.144.6.1151 }}
*{{cite journal | author=Fransen M, Terlecky SR, Subramani S |title=Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8087-92 |year= 1998 |pmid= 9653144 |doi=  }}
* {{cite journal | vauthors = Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y | title = The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12593–604 | date = Apr 1999 | pmid = 10212238 | doi = 10.1074/jbc.274.18.12593 }}
*{{cite journal | author=Will GK, Soukupova M, Hong X, ''et al.'' |title=Identification and characterization of the human orthologue of yeast Pex14p. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2265-77 |year= 1999 |pmid= 10022913 |doi= }}
* {{cite journal | vauthors = Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ | title = PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis | journal = The Journal of Cell Biology | volume = 148 | issue = 5 | pages = 931–44 | date = Mar 2000 | pmid = 10704444 | pmc = 2174547 | doi = 10.1083/jcb.148.5.931 }}
*{{cite journal | author=Girzalsky W, Rehling P, Stein K, ''et al.'' |title=Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes. |journal=J. Cell Biol. |volume=144 |issue= 6 |pages= 1151-62 |year= 1999 |pmid= 10087260 |doi= }}
* {{cite journal | vauthors = Gavva NR, Wen SC, Daftari P, Moniwa M, Yang WM, Yang-Feng LP, Seto E, Davie JR, Shen CK | title = NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor | journal = Genomics | volume = 79 | issue = 3 | pages = 423–31 | date = Mar 2002 | pmid = 11863372 | doi = 10.1006/geno.2002.6714 }}
*{{cite journal | author=Shimizu N, Itoh R, Hirono Y, ''et al.'' |title=The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12593-604 |year= 1999 |pmid= 10212238 |doi= }}
* {{cite journal | vauthors = Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y | title = Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import | journal = Molecular and Cellular Biology | volume = 22 | issue = 6 | pages = 1639–55 | date = Mar 2002 | pmid = 11865044 | pmc = 135613 | doi = 10.1128/MCB.22.6.1639-1655.2002 }}
*{{cite journal | author=Sacksteder KA, Jones JM, South ST, ''et al.'' |title=PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. |journal=J. Cell Biol. |volume=148 |issue= 5 |pages= 931-44 |year= 2000 |pmid= 10704444 |doi= }}
* {{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}
*{{cite journal | author=Gavva NR, Wen SC, Daftari P, ''et al.'' |title=NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor. |journal=Genomics |volume=79 |issue= 3 |pages= 423-31 |year= 2002 |pmid= 11863372 |doi= 10.1006/geno.2002.6714 }}
* {{cite journal | vauthors = Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP | title = Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 3 | pages = 243–52 | date = Mar 2002 | pmid = 12096124 | doi = 10.1074/mcp.M100025-MCP200 }}
*{{cite journal | author=Otera H, Setoguchi K, Hamasaki M, ''et al.'' |title=Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1639-55 |year= 2002 |pmid= 11865044 |doi= }}
* {{cite journal | vauthors = Oliveira ME, Reguenga C, Gouveia AM, Guimarães CP, Schliebs W, Kunau WH, Silva MT, Sá-Miranda C, Azevedo JE | title = Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction | journal = Biochimica et Biophysica Acta | volume = 1567 | issue = 1-2 | pages = 13–22 | date = Dec 2002 | pmid = 12488033 | doi = 10.1016/s0005-2736(02)00635-1 }}
*{{cite journal | author=Alland L, David G, Shen-Li H, ''et al.'' |title=Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2743-50 |year= 2002 |pmid= 11909966 |doi= }}
* {{cite journal | vauthors = Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP | title = Potential role for Pex19p in assembly of PTS-receptor docking complexes | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 12615–24 | date = Mar 2004 | pmid = 14715663 | doi = 10.1074/jbc.M304941200 }}
*{{cite journal | author=Fransen M, Brees C, Ghys K, ''et al.'' |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. |journal=Mol. Cell Proteomics |volume=1 |issue= 3 |pages= 243-52 |year= 2002 |pmid= 12096124 |doi= }}
* {{cite journal | vauthors = Shimozawa N, Tsukamoto T, Nagase T, Takemoto Y, Koyama N, Suzuki Y, Komori M, Osumi T, Jeannette G, Wanders RJ, Kondo N | title = Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene | journal = Human Mutation | volume = 23 | issue = 6 | pages = 552–8 | date = Jun 2004 | pmid = 15146459 | doi = 10.1002/humu.20032 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Oliveira ME, Reguenga C, Gouveia AM, ''et al.'' |title=Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction. |journal=Biochim. Biophys. Acta |volume=1567 |issue= 1-2 |pages= 13-22 |year= 2003 |pmid= 12488033 |doi= }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Nguyen T, Bjorkman J, Paton BC, Crane DI | title = Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance | journal = Journal of Cell Science | volume = 119 | issue = Pt 4 | pages = 636–45 | date = Feb 2006 | pmid = 16449325 | doi = 10.1242/jcs.02776 }}
*{{cite journal  | author=Fransen M, Vastiau I, Brees C, ''et al.'' |title=Potential role for Pex19p in assembly of PTS-receptor docking complexes. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12615-24 |year= 2004 |pmid= 14715663 |doi= 10.1074/jbc.M304941200 }}
*{{cite journal | author=Shimozawa N, Tsukamoto T, Nagase T, ''et al.'' |title=Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene. |journal=Hum. Mutat. |volume=23 |issue= 6 |pages= 552-8 |year= 2004 |pmid= 15146459 |doi= 10.1002/humu.20032 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Nguyen T, Bjorkman J, Paton BC, Crane DI |title=Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance. |journal=J. Cell. Sci. |volume=119 |issue= Pt 4 |pages= 636-45 |year= 2006 |pmid= 16449325 |doi= 10.1242/jcs.02776 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pbd  GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
* [https://www.ncbi.nlm.nih.gov/omim/170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666,170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666 OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
* {{ ELM|TRG_PEX_1}}
* {{ ELM|TRG_PEX_2}}

Latest revision as of 17:58, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
SymbolPex14_N
PfamPF04695
InterProIPR006785

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[1][2]

Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[2]

Interactions

PEX14 has been shown to interact with

References

  1. ↑ Fransen M, Terlecky SR, Subramani S (Jul 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144.
  2. ↑ 2.0 2.1 "Entrez Gene: PEX14 peroxisomal biogenesis factor 14".
  3. ↑ 3.0 3.1 Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (Mar 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
  4. ↑ Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480.
  5. ↑ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.
  6. ↑ 6.0 6.1 Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H (Jun 2007). "The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies". Traffic. 8 (6): 687–701. doi:10.1111/j.1600-0854.2007.00560.x. PMID 17461798.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=PEX14&oldid=1411836"