PDK2

Pyruvate dehydrogenase kinase, isozyme 2
File:PBB Protein PDK2 image.jpg PDB rendering based on 1jm6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jm6​, 2btz​, 2bu2​, 2bu5​, 2bu6​, 2bu7​, 2bu8​
Identifiers
Symbols	PDK2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68265
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDK2 202590 s at tn.png
File:PBB GE PDK2 213724 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pyruvate dehydrogenase kinase, isozyme 2, also known as PDK2, is a human gene. It codes for an isozyme of pyruvate dehydrogenase kinase.

Further reading

• Sugden MC, Holness MJ (2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs". Am. J. Physiol. Endocrinol. Metab. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002. PMID 12676647.
• Gudi R, Bowker-Kinley MM, Kedishvili NY; et al. (1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J. Biol. Chem. 270 (48): 28989–94. PMID 7499431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2". Biochem. J. 339 ( Pt 2): 319–28. PMID 10191262.
• Gold MR, Scheid MP, Santos L; et al. (1999). "The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase". J. Immunol. 163 (4): 1894–905. PMID 10438924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baker JC, Yan X, Peng T; et al. (2000). "Marked differences between two isoforms of human pyruvate dehydrogenase kinase". J. Biol. Chem. 275 (21): 15773–81. doi:10.1074/jbc.M909488199. PMID 10748134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steussy CN, Popov KM, Bowker-Kinley MM; et al. (2001). "Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase". J. Biol. Chem. 276 (40): 37443–50. doi:10.1074/jbc.M104285200. PMID 11483605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolobova E, Tuganova A, Boulatnikov I, Popov KM (2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". Biochem. J. 358 (Pt 1): 69–77. PMID 11485553.CS1 maint: Multiple names: authors list (link)
• Korotchkina LG, Patel MS (2001). "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase". J. Biol. Chem. 276 (40): 37223–9. doi:10.1074/jbc.M103069200. PMID 11486000.
• Peters SJ, Harris RA, Wu P; et al. (2002). "Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet". Am. J. Physiol. Endocrinol. Metab. 281 (6): E1151–8. PMID 11701428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tuganova A, Boulatnikov I, Popov KM (2002). "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex". Biochem. J. 366 (Pt 1): 129–36. doi:10.1042/BJ20020301. PMID 11978179.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boulatnikov I, Popov KM (2003). "Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase". Biochim. Biophys. Acta. 1645 (2): 183–92. PMID 12573248.
• Hiromasa Y, Roche TE (2003). "Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase". J. Biol. Chem. 278 (36): 33681–93. doi:10.1074/jbc.M212733200. PMID 12816949.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watt MJ, Heigenhauser GJ, LeBlanc PJ; et al. (2005). "Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise". J. Appl. Physiol. 97 (4): 1261–7. doi:10.1152/japplphysiol.00132.2004. PMID 15169745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bao H, Kasten SA, Yan X, Roche TE (2004). "Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP". Biochemistry. 43 (42): 13432–41. doi:10.1021/bi049488x. PMID 15491150.CS1 maint: Multiple names: authors list (link)
• Bao H, Kasten SA, Yan X; et al. (2004). "Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP". Biochemistry. 43 (42): 13442–51. doi:10.1021/bi0494875. PMID 15491151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abbot EL, McCormack JG, Reynet C; et al. (2005). "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells". FEBS J. 272 (12): 3004–14. doi:10.1111/j.1742-4658.2005.04713.x. PMID 15955060.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)