PDGFB

Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
File:PBB Protein PDGFB image.jpg PDB rendering based on 1pdg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1pdg​
Identifiers
Symbols	PDGFB ; FLJ12858; PDGF2; SIS; SSV; c-sis
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74303
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDGFB 204200 s at tn.png
File:PBB GE PDGFB 216061 x at tn.png
File:PBB GE PDGFB 217112 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), also known as PDGFB, is a human gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

See also

• Platelet-derived growth factor

Further reading

• Kurup S, Abramsson A, Li JP; et al. (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)