PDE6G: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: fix deprecated Citation Style 1 parameters (Task 9))
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma''' is an [[enzyme]] that in humans is encoded by the ''PDE6G'' [[gene]].<ref name="pmid2155175">{{cite journal |vauthors=Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL | title = Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene | journal = Genomics | volume = 6 | issue = 2 | pages = 272–83 |date=Apr 1990 | pmid = 2155175 | pmc =  | doi =10.1016/0888-7543(90)90567-E }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5148| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDE6G_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fqj.
| PDB = {{PDB2|1fqj}}
| Name = Phosphodiesterase 6G, cGMP-specific, rod, gamma
| HGNCid = 8789
| Symbol = PDE6G
| AltSymbols =; DKFZp686C0587; MGC125749; PDEG
| OMIM = 180073
| ECnumber = 
| Homologene = 1955
| MGIid = 97526
| GeneAtlas_image1 = PBB_GE_PDE6G_210060_at_tn.png
| Function = {{GNF_GO|id=GO:0004114 |text = 3',5'-cyclic-nucleotide phosphodiesterase activity}} {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030553 |text = cGMP binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0045742 |text = positive regulation of epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0045745 |text = positive regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5148
    | Hs_Ensembl = ENSG00000185527
    | Hs_RefseqProtein = NP_002593
    | Hs_RefseqmRNA = NM_002602
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77227655
    | Hs_GenLoc_end = 77234018
    | Hs_Uniprot = P18545
    | Mm_EntrezGene = 18588
    | Mm_Ensembl = ENSMUSG00000025386
    | Mm_RefseqmRNA = XM_994440
    | Mm_RefseqProtein = XP_999534
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120263700
    | Mm_GenLoc_end = 120269573
    | Mm_Uniprot = Q542R6
  }}
}}
'''Phosphodiesterase 6G, cGMP-specific, rod, gamma''', also known as '''PDE6G''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5148| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 53: Line 7:
| summary_text =  
| summary_text =  
}}
}}
==Interactions==
PDE6G has been shown to [[Protein-protein interaction|interact]] with [[Beta adrenergic receptor kinase]]<ref name=pmid12624098>{{cite journal |last=Wan |first=Kah Fei |authorlink= |author2=Sambi Balwinder S |author3=Tate Rothwelle |author4=Waters Catherine |author5=Pyne Nigel J  |date=May 2003 |title=The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor |journal=J. Biol. Chem. |volume=278 |issue=20 |pages=18658–63 |publisher= |location = United States| issn = 0021-9258| pmid = 12624098 |doi = 10.1074/jbc.M212103200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Src (gene)|Src]].<ref name=pmid12624098/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Cotran PR, Bruns GA, Berson EL, Dryja TP |title=Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase. |journal=Exp. Eye Res. |volume=53 |issue= 5 |pages= 557-64 |year= 1992 |pmid= 1683837 |doi=  }}
*{{cite journal  |vauthors=Cotran PR, Bruns GA, Berson EL, Dryja TP |title=Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase. |journal=Exp. Eye Res. |volume=53 |issue= 5 |pages= 557–64 |year= 1992 |pmid= 1683837 |doi=10.1016/0014-4835(91)90213-X }}
*{{cite journal  | author=Piriev NI, Purishko VA, Khramtsov NV, Lipkin VM |title=[The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase] |journal=Dokl. Akad. Nauk SSSR |volume=315 |issue= 1 |pages= 229-31 |year= 1991 |pmid= 1965799 |doi=  }}
*{{cite journal  | last=Piriev | first=N. I. |author2=V. A. Purishko |author3=N. V. Khramtsov |author4=V. M. Lipkin |trans-title=The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase |journal=[[Doklady Akademii Nauk SSSR]] |volume=315 |issue= 1 |pages= 229–31 |year= 1991 |pmid= 1965799 |doi=  | title=The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase }}
*{{cite journal  | author=Pittler SJ, Baehr W, Wasmuth JJ, ''et al.'' |title=Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene. |journal=Genomics |volume=6 |issue= 2 |pages= 272-83 |year= 1990 |pmid= 2155175 |doi= }}
*{{cite journal   |vauthors=Tuteja N, Danciger M, Klisak I, etal |title=Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina. |journal=Gene |volume=88 |issue= 2 |pages= 227–32 |year= 1990 |pmid= 2161380 |doi=10.1016/0378-1119(90)90035-P }}
*{{cite journal | author=Tuteja N, Danciger M, Klisak I, ''et al.'' |title=Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina. |journal=Gene |volume=88 |issue= 2 |pages= 227-32 |year= 1990 |pmid= 2161380 |doi=  }}
*{{cite journal  |vauthors=Piriev NI, Khramtsov NV, Lipkin VM |title=Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells. |journal=Gene |volume=151 |issue= 1–2 |pages= 297–301 |year= 1995 |pmid= 7828894 |doi=10.1016/0378-1119(94)90674-2 }}
*{{cite journal  | author=Piriev NI, Khramtsov NV, Lipkin VM |title=Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells. |journal=Gene |volume=151 |issue= 1-2 |pages= 297-301 |year= 1995 |pmid= 7828894 |doi=  }}
*{{cite journal  |vauthors=Hahn LB, Berson EL, Dryja TP |title=Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa |journal=Invest. Ophthalmol. Vis. Sci. |volume=35 |issue= 3 |pages= 1077–82 |year= 1994 |pmid= 8125719 |doi=  }}
*{{cite journal  | author=Hahn LB, Berson EL, Dryja TP |title=Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa. |journal=Invest. Ophthalmol. Vis. Sci. |volume=35 |issue= 3 |pages= 1077-82 |year= 1994 |pmid= 8125719 |doi=  }}
*{{cite journal   |vauthors=Dollfus H, Mattei MG, Rozet JM, etal |title=Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25) |journal=Genomics |volume=17 |issue= 2 |pages= 526–8 |year= 1993 |pmid= 8406511 |doi= 10.1006/geno.1993.1364 }}
*{{cite journal | author=Dollfus H, Mattei MG, Rozet JM, ''et al.'' |title=Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25). |journal=Genomics |volume=17 |issue= 2 |pages= 526-8 |year= 1993 |pmid= 8406511 |doi= 10.1006/geno.1993.1364 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Wan KF, Sambi BS, Frame M, etal |title=The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 37802–8 |year= 2001 |pmid= 11502744 |doi= 10.1074/jbc.M105087200 }}
*{{cite journal | author=Wan KF, Sambi BS, Frame M, ''et al.'' |title=The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 37802-8 |year= 2001 |pmid= 11502744 |doi= 10.1074/jbc.M105087200 }}
*{{cite journal   |vauthors=Wistow G, Bernstein SL, Wyatt MK, etal |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts |journal=Mol. Vis. |volume=8 |issue=  |pages= 196–204 |year= 2002 |pmid= 12107411 |doi=  }}
*{{cite journal | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. |journal=Mol. Vis. |volume=8 |issue=  |pages= 196-204 |year= 2002 |pmid= 12107411 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Wan KF, Sambi BS, Tate R, etal |title=The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18658–63 |year= 2003 |pmid= 12624098 |doi= 10.1074/jbc.M212103200 }}
*{{cite journal | author=Wan KF, Sambi BS, Tate R, ''et al.'' |title=The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18658-63 |year= 2003 |pmid= 12624098 |doi= 10.1074/jbc.M212103200 }}
*{{cite journal   |vauthors=Morin F, Vannier B, Houdart F, etal |title=A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins |journal=Mol. Vis. |volume=9 |issue=  |pages= 449–59 |year= 2003 |pmid= 14502124 |doi=  }}
*{{cite journal | author=Morin F, Vannier B, Houdart F, ''et al.'' |title=A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. |journal=Mol. Vis. |volume=9 |issue=  |pages= 449-59 |year= 2003 |pmid= 14502124 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1417/  GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview]
 
{{PDB Gallery|geneid=5148}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-17-stub}}

Revision as of 21:24, 14 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.[1][2]


Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase[3] and Src.[3]

References

  1. ↑ Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (Apr 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
  2. ↑ "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
  3. ↑ 3.0 3.1 Wan, Kah Fei; Sambi Balwinder S; Tate Rothwelle; Waters Catherine; Pyne Nigel J (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. United States. 278 (20): 18658–63. doi:10.1074/jbc.M212103200. ISSN 0021-9258. PMID 12624098.

Further reading

External links



Retrieved from "https://www.wikidoc.org/index.php?title=PDE6G&oldid=1418003"