PDCD4

Programmed cell death 4 (neoplastic transformation inhibitor)
File:PBB Protein PDCD4 image.jpg PDB rendering based on 2ggf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ggf​, 2hm8​, 2iol​, 2ion​, 2ios​, 2nsz​
Identifiers
Symbols	PDCD4 ; H731; MGC33046; MGC33047
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7879
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDCD4 202731 at tn.png
File:PBB GE PDCD4 202730 s at tn.png
File:PBB GE PDCD4 212593 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Programmed cell death 4 (neoplastic transformation inhibitor), also known as PDCD4, is a human gene.

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.

Further reading

• Göke R, Gregel C, Göke A; et al. (2004). "Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells". Ann. N. Y. Acad. Sci. 1014: 220–1. PMID 15153438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Shibahara K, Asano M, Ishida Y; et al. (1996). "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death". Gene. 166 (2): 297–301. PMID 8543179.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Azzoni L, Zatsepina O, Abebe B; et al. (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". J. Immunol. 161 (7): 3493–500. PMID 9759869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z (2000). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody". Pathol. Int. 49 (12): 1067–77. PMID 10632927.CS1 maint: Multiple names: authors list (link)
• Soejima H, Miyoshi O, Yoshinaga H; et al. (2000). "Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 113–4. PMID 10640828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang MJ, Ahn HS, Lee JY; et al. (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Y, Knösel T, Kristiansen G; et al. (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis". J. Pathol. 200 (5): 640–6. doi:10.1002/path.1378. PMID 12898601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang HS, Cho MH, Zakowicz H; et al. (2004). "A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A". Mol. Cell. Biol. 24 (9): 3894–906. PMID 15082783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Göke R, Barth P, Schmidt A; et al. (2004). "Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1)". Am. J. Physiol., Cell Physiol. 287 (6): C1541–6. doi:10.1152/ajpcell.00025.2004. PMID 15317660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palamarchuk A, Efanov A, Maximov V; et al. (2006). "Akt phosphorylates and regulates Pdcd4 tumor suppressor protein". Cancer Res. 65 (24): 11282–6. doi:10.1158/0008-5472.CAN-05-3469. PMID 16357133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang HS, Matthews CP, Clair T; et al. (2006). "Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion". Mol. Cell. Biol. 26 (4): 1297–306. doi:10.1128/MCB.26.4.1297-1306.2006. PMID 16449643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)