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{{Infobox_gene}}
{{PBB_Controls
'''Proprotein convertase subtilisin/kexin type 6''' is an [[enzyme]] that in humans is encoded by the ''PCSK6'' [[gene]].<ref name="pmid1741956">{{cite journal | vauthors = Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ | title = Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15 | journal = DNA Cell Biol | volume = 10 | issue = 10 | pages = 757–69 | date = Jan 1992 | pmid = 1741956 | pmc =  | doi = 10.1089/dna.1991.10.757 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCSK6 proprotein convertase subtilisin/kexin type 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5046| accessdate = }}</ref> ''PCSK6'' is a protease that cleaves [[NODAL]] into an active form to help trigger the development of left/right (LR) asymmetry.<ref>{{cite journal | vauthors = Constam DB, Robertson EJ | title = SPC4/PACE4 regulates a TGFbeta signaling network during axis formation. | journal = Genes & Development | volume = 14 | issue = 9 | pages = 1146–55 | date = May 1, 2000 | pmid = 10809672 | pmc = 316583 | doi = 10.1101/gad.14.9.1146 }}</ref> It may also be involved in left and right [[handedness]] in humans.<ref>{{cite journal | vauthors = Scerri TS, Brandler WM, Paracchini S, Morris AP, Ring SM, Richardson AJ, Talcott JB, Stein J, Monaco AP | title = PCSK6 is associated with handedness in individuals with dyslexia. | journal = Human Molecular Genetics | volume = 20 | issue = 3 | pages = 608–14 | date = Feb 1, 2011 | pmid = 21051773 | pmc = 3016905 | doi = 10.1093/hmg/ddq475 }}</ref><ref>{{cite journal | vauthors = Brandler WM, Morris AP, Evans DM, Scerri TS, Kemp JP, Timpson NJ, St Pourcain B, Smith GD, Ring SM, Stein J, Monaco AP, Talcott JB, Fisher SE, Webber C, Paracchini S | title = Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. | journal = PLOS Genetics | volume = 9 | issue = 9 | pages = e1003751 | date = September 2013 | pmid = 24068947 | pmc = 3772043 | doi = 10.1371/journal.pgen.1003751 }}</ref><ref>{{cite journal | vauthors = Shore R, Covill L, Pettigrew KA, Brandler WM, Diaz R, Xu Y, Tello JA, Talcott JB, Newbury DF, Stein J, Monaco AP, Paracchini S | title = The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts. | journal = Human Molecular Genetics | volume = 25 | issue = 6 | date = March 16, 2016 | doi = 10.1093/hmg/ddw047 | pages=1771–1779 | pmid=26908617 | pmc=4986331}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proprotein convertase subtilisin/kexin type 6
| HGNCid = 8569
| Symbol = PCSK6
| AltSymbols =; PACE4; SPC4
| OMIM = 167405
| ECnumber = 
| Homologene = 20569
| MGIid = 102897
| GeneAtlas_image1 = PBB_GE_PCSK6_207414_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PCSK6_211263_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PCSK6_211262_at_tn.png
| Function = {{GNF_GO|id=GO:0004289 |text = subtilase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007354 |text = zygotic determination of anterior/posterior axis, embryo}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5046
    | Hs_Ensembl = ENSG00000140479
    | Hs_RefseqProtein = XP_001130900
    | Hs_RefseqmRNA = XM_001130900
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 99661657
    | Hs_GenLoc_end = 99847396
    | Hs_Uniprot = P29122
    | Mm_EntrezGene = 18553
    | Mm_Ensembl = ENSMUSG00000030513
    | Mm_RefseqmRNA = XM_355911
    | Mm_RefseqProtein = XP_355911
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 65741163
    | Mm_GenLoc_end = 65929284
    | Mm_Uniprot = 
  }}
}}
'''Proprotein convertase subtilisin/kexin type 6''', also known as '''PCSK6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCSK6 proprotein convertase subtilisin/kexin type 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5046| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the [[subtilisin]]-like [[proprotein convertase]] family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a [[calcium in biology|calcium]]-dependent serine [[endoprotease]] that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - [[transforming growth factor beta]] related proteins, proalbumin, and [[von Willebrand factor]]. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PCSK6 proprotein convertase subtilisin/kexin type 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5046| accessdate = }}</ref>
}}


==References==
PCSK6 also cleaves and activates [[corin]], a serine [[protease]] that regulates sodium homeostasis and blood pressure.<ref name=nm>{{cite journal | vauthors = Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q | title = PCSK6-mediated corin activation is essential for normal blood pressure | journal = Nature Medicine | volume = 21 | issue = 9 | pages = 1048–53 | date = Sep 2015 | pmid = 26259032 | doi = 10.1038/nm.3920 | pmc=4710517}}</ref>
{{reflist|2}}
 
==Further reading==
== Clinical significance ==
 
This gene is thought to play a role in tumor progression.<ref name="entrez" />
 
PCSK6 deficiency causes salt-sensitive [[hypertension]] in mice.<ref name=nm />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shore R, Covill L, Pettigrew KA, Diaz R, Xu Y, Tello J, Talcott J, Newbury D, Stein J, Monaco A | title = The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts  | journal = Hum Mol Gen | volume = 25 | issue = 9 | pages = 1771–1779 | year = 2016 | pmid = 26604689 | doi = 10.1093/hmg/ddw047 }}
| citations =  
* {{cite journal | vauthors = Bassi DE, Mahloogi H, Klein-Szanto AJ | title = The proprotein convertases furin and PACE4 play a significant role in tumor progression | journal = Mol. Carcinog. | volume = 28 | issue = 2 | pages = 63–9 | year = 2000 | pmid = 10900462 | doi = 10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C }}
*{{cite journal | author=Bassi DE, Mahloogi H, Klein-Szanto AJ |title=The proprotein convertases furin and PACE4 play a significant role in tumor progression. |journal=Mol. Carcinog. |volume=28 |issue= 2 |pages= 63-9 |year= 2000 |pmid= 10900462 |doi= }}
* {{cite journal | vauthors = Moulard M, Decroly E | title = Maturation of HIV envelope glycoprotein precursors by cellular endoproteases | journal = Biochim. Biophys. Acta | volume = 1469 | issue = 3 | pages = 121–32 | year = 2001 | pmid = 11063880 | doi = 10.1016/S0304-4157(00)00014-9 }}
*{{cite journal | author=Moulard M, Decroly E |title=Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. |journal=Biochim. Biophys. Acta |volume=1469 |issue= 3 |pages= 121-32 |year= 2001 |pmid= 11063880 |doi= }}
* {{cite journal | vauthors = Seidah NG, Prat A | title = Precursor convertases in the secretory pathway, cytosol and extracellular milieu | journal = Essays Biochem. | volume = 38 | issue =  | pages = 79–94 | year = 2003 | pmid = 12463163 | doi =  }}
*{{cite journal | author=Seidah NG, Prat A |title=Precursor convertases in the secretory pathway, cytosol and extracellular milieu. |journal=Essays Biochem. |volume=38 |issue=  |pages= 79-94 |year= 2003 |pmid= 12463163 |doi=  }}
* {{cite journal | vauthors = Tsuji A, Higashine K, Hine C, Mori K, Tamai Y, Nagamune H, Matsuda Y | title = Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms. | journal = Biochem. Biophys. Res. Commun. | volume = 204 | issue = 3 | pages = 1381–2 | year = 1994 | pmid = 7980617 | doi = 10.1006/bbrc.1994.2616 }}
*{{cite journal | author=Kiefer MC, Tucker JE, Joh R, ''et al.'' |title=Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. |journal=DNA Cell Biol. |volume=10 |issue= 10 |pages= 757-69 |year= 1992 |pmid= 1741956 |doi=  }}
* {{cite journal | vauthors = Tsuji A, Higashine K, Hine C, Mori K, Tamai Y, Nagamune H, Matsuda Y | title = Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms | journal = Biochem. Biophys. Res. Commun. | volume = 200 | issue = 2 | pages = 943–50 | year = 1994 | pmid = 8179631 | doi = 10.1006/bbrc.1994.1541 }}
*{{cite journal  | author=Tsuji A, Higashine K, Hine C, ''et al.'' |title="Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms.". |journal=Biochem. Biophys. Res. Commun. |volume=204 |issue= 3 |pages= 1381-2 |year= 1994 |pmid= 7980617 |doi= }}
* {{cite journal | vauthors = Vollenweider F, Benjannet S, Decroly E, Savaria D, Lazure C, Thomas G, Chrétien M, Seidah NG | title = Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases | journal = Biochem. J. | volume = 314 | issue = Pt 2 | pages = 521–32 | year = 1996 | pmid = 8670066 | pmc = 1217081 | doi =  }}
*{{cite journal | author=Tsuji A, Higashine K, Hine C, ''et al.'' |title=Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 2 |pages= 943-50 |year= 1994 |pmid= 8179631 |doi= 10.1006/bbrc.1994.1541 }}
* {{cite journal | vauthors = Zhong M, Benjannet S, Lazure C, Munzer S, Seidah NG | title = Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform | journal = FEBS Lett. | volume = 396 | issue = 1 | pages = 31–6 | year = 1997 | pmid = 8906861 | doi = 10.1016/0014-5793(96)01059-9 }}
*{{cite journal | author=Vollenweider F, Benjannet S, Decroly E, ''et al.'' |title=Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases. |journal=Biochem. J. |volume=314 ( Pt 2) |issue= |pages= 521-32 |year= 1996 |pmid= 8670066 |doi=  }}
* {{cite journal | vauthors = Decroly E, Wouters S, Di Bello C, Lazure C, Ruysschaert JM, Seidah NG | title = Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines | journal = J. Biol. Chem. | volume = 271 | issue = 48 | pages = 30442–50 | year = 1997 | pmid = 8940009 | doi = 10.1074/jbc.271.48.30442 }}
*{{cite journal | author=Zhong M, Benjannet S, Lazure C, ''et al.'' |title=Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform. |journal=FEBS Lett. |volume=396 |issue= 1 |pages= 31-6 |year= 1997 |pmid= 8906861 |doi= }}
* {{cite journal | vauthors = Inocencio NM, Sucic JF, Moehring JM, Spence MJ, Moehring TJ | title = Endoprotease activities other than furin and PACE4 with a role in processing of HIV-I gp160 glycoproteins in CHO-K1 cells | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1344–8 | year = 1997 | pmid = 8995442 | doi = 10.1074/jbc.272.2.1344 }}
*{{cite journal | author=Decroly E, Wouters S, Di Bello C, ''et al.'' |title=Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30442-50 |year= 1997 |pmid= 8940009 |doi= }}
* {{cite journal | vauthors = Mori K, Kii S, Tsuji A, Nagahama M, Imamaki A, Hayashi K, Akamatsu T, Nagamune H, Matsuda Y | title = A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus | journal = J. Biochem. | volume = 121 | issue = 5 | pages = 941–8 | year = 1997 | pmid = 9192737 | doi = 10.1093/oxfordjournals.jbchem.a021677 }}
*{{cite journal | author=Inocencio NM, Sucic JF, Moehring JM, ''et al.'' |title=Endoprotease activities other than furin and PACE4 with a role in processing of HIV-I gp160 glycoproteins in CHO-K1 cells. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1344-8 |year= 1997 |pmid= 8995442 |doi= }}
* {{cite journal | vauthors = Tsuji A, Hine C, Tamai Y, Yonemoto K, Mori K, Yoshida S, Bando M, Sakai E, Mori K, Akamatsu T, Matsuda Y | title = Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease | journal = J. Biochem. | volume = 122 | issue = 2 | pages = 438–52 | year = 1997 | pmid = 9378725 | doi = 10.1093/oxfordjournals.jbchem.a021772 }}
*{{cite journal | author=Mori K, Kii S, Tsuji A, ''et al.'' |title=A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus. |journal=J. Biochem. |volume=121 |issue= 5 |pages= 941-8 |year= 1997 |pmid= 9192737 |doi= }}
* {{cite journal | vauthors = Moulard M, Chaloin L, Canarelli S, Mabrouk K, Darbon H, Challoin L | title = Retroviral envelope glycoprotein processing: structural investigation of the cleavage site | journal = Biochemistry | volume = 37 | issue = 13 | pages = 4510–7 | year = 1998 | pmid = 9521771 | doi = 10.1021/bi972662f }}
*{{cite journal | author=Tsuji A, Hine C, Tamai Y, ''et al.'' |title=Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease. |journal=J. Biochem. |volume=122 |issue= 2 |pages= 438-52 |year= 1997 |pmid= 9378725 |doi= }}
* {{cite journal | vauthors = Nagahama M, Taniguchi T, Hashimoto E, Imamaki A, Mori K, Tsuji A, Matsuda Y | title = Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4) | journal = FEBS Lett. | volume = 434 | issue = 1–2 | pages = 155–9 | year = 1998 | pmid = 9738469 | doi = 10.1016/S0014-5793(98)00970-3 }}
*{{cite journal | author=Moulard M, Chaloin L, Canarelli S, ''et al.'' |title=Retroviral envelope glycoprotein processing: structural investigation of the cleavage site. |journal=Biochemistry |volume=37 |issue= 13 |pages= 4510-7 |year= 1998 |pmid= 9521771 |doi= 10.1021/bi972662f }}
* {{cite journal | vauthors = Viale A, Ortola C, Hervieu G, Furuta M, Barbero P, Steiner DF, Seidah NG, Nahon JL | title = Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals | journal = J. Biol. Chem. | volume = 274 | issue = 10 | pages = 6536–45 | year = 1999 | pmid = 10037747 | doi = 10.1074/jbc.274.10.6536 }}
*{{cite journal | author=Nagahama M, Taniguchi T, Hashimoto E, ''et al.'' |title=Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4). |journal=FEBS Lett. |volume=434 |issue= 1-2 |pages= 155-9 |year= 1998 |pmid= 9738469 |doi= }}
* {{cite journal | vauthors = Mori K, Imamaki A, Nagata K, Yonetomi Y, Kiyokage-Yoshimoto R, Martin TJ, Gillespie MT, Nagahama M, Tsuji A, Matsuda Y | title = Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells | journal = J. Biochem. | volume = 125 | issue = 3 | pages = 627–33 | year = 1999 | pmid = 10050053 | doi = 10.1093/oxfordjournals.jbchem.a022329 }}
*{{cite journal | author=Viale A, Ortola C, Hervieu G, ''et al.'' |title=Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6536-45 |year= 1999 |pmid= 10037747 |doi= }}
* {{cite journal | vauthors = Sucic JF, Moehring JM, Inocencio NM, Luchini JW, Moehring TJ | title = Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain | journal = Biochem. J. | volume = 339 | issue = 3 | pages = 639–47 | year = 1999 | pmid = 10215603 | pmc = 1220200 | doi = 10.1042/0264-6021:3390639 }}
*{{cite journal | author=Mori K, Imamaki A, Nagata K, ''et al.'' |title=Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells. |journal=J. Biochem. |volume=125 |issue= 3 |pages= 627-33 |year= 1999 |pmid= 10050053 |doi= }}
* {{cite journal | vauthors = Tsuji A, Yoshida S, Hasegawa S, Bando M, Yoshida I, Koide S, Mori K, Matsuda Y | title = Human subtilisin-like proprotein convertase, PACE4 (SPC4) gene expression is highly regulated through E-box elements in HepG2 and GH4C1 cells | journal = J. Biochem. | volume = 126 | issue = 3 | pages = 494–502 | year = 2000 | pmid = 10467164 | doi = 10.1093/oxfordjournals.jbchem.a022478 }}
*{{cite journal | author=Sucic JF, Moehring JM, Inocencio NM, ''et al.'' |title=Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain. |journal=Biochem. J. |volume=339 ( Pt 3) |issue= |pages= 639-47 |year= 1999 |pmid= 10215603 |doi= }}
*{{cite journal | author=Tsuji A, Yoshida S, Hasegawa S, ''et al.'' |title=Human subtilisin-like proprotein convertase, PACE4 (SPC4) gene expression is highly regulated through E-box elements in HepG2 and GH4C1 cells. |journal=J. Biochem. |volume=126 |issue= 3 |pages= 494-502 |year= 2000 |pmid= 10467164 |doi= }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
{{gene-15-stub}}

Latest revision as of 14:16, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proprotein convertase subtilisin/kexin type 6 is an enzyme that in humans is encoded by the PCSK6 gene.[1][2] PCSK6 is a protease that cleaves NODAL into an active form to help trigger the development of left/right (LR) asymmetry.[3] It may also be involved in left and right handedness in humans.[4][5][6]

Function

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

PCSK6 also cleaves and activates corin, a serine protease that regulates sodium homeostasis and blood pressure.[7]

Clinical significance

This gene is thought to play a role in tumor progression.[2]

PCSK6 deficiency causes salt-sensitive hypertension in mice.[7]

References

  1. ↑ Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ (Jan 1992). "Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15". DNA Cell Biol. 10 (10): 757–69. doi:10.1089/dna.1991.10.757. PMID 1741956.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: PCSK6 proprotein convertase subtilisin/kexin type 6".
  3. ↑ Constam DB, Robertson EJ (May 1, 2000). "SPC4/PACE4 regulates a TGFbeta signaling network during axis formation". Genes & Development. 14 (9): 1146–55. doi:10.1101/gad.14.9.1146. PMC 316583. PMID 10809672.
  4. ↑ Scerri TS, Brandler WM, Paracchini S, Morris AP, Ring SM, Richardson AJ, Talcott JB, Stein J, Monaco AP (Feb 1, 2011). "PCSK6 is associated with handedness in individuals with dyslexia". Human Molecular Genetics. 20 (3): 608–14. doi:10.1093/hmg/ddq475. PMC 3016905. PMID 21051773.
  5. ↑ Brandler WM, Morris AP, Evans DM, Scerri TS, Kemp JP, Timpson NJ, St Pourcain B, Smith GD, Ring SM, Stein J, Monaco AP, Talcott JB, Fisher SE, Webber C, Paracchini S (September 2013). "Common variants in left/right asymmetry genes and pathways are associated with relative hand skill". PLOS Genetics. 9 (9): e1003751. doi:10.1371/journal.pgen.1003751. PMC 3772043. PMID 24068947.
  6. ↑ Shore R, Covill L, Pettigrew KA, Brandler WM, Diaz R, Xu Y, Tello JA, Talcott JB, Newbury DF, Stein J, Monaco AP, Paracchini S (March 16, 2016). "The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts". Human Molecular Genetics. 25 (6): 1771–1779. doi:10.1093/hmg/ddw047. PMC 4986331. PMID 26908617.
  7. ↑ 7.0 7.1 Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q (Sep 2015). "PCSK6-mediated corin activation is essential for normal blood pressure". Nature Medicine. 21 (9): 1048–53. doi:10.1038/nm.3920. PMC 4710517. PMID 26259032.

Further reading


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