PCDHA4: Difference between revisions
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'''Protocadherin alpha-4''' is a [[protein]] that in humans is encoded by the ''PCDHA4'' [[gene]].<ref name="pmid10380929">{{cite journal | vauthors = Wu Q, Maniatis T | title = A striking organization of a large family of human neural cadherin-like cell adhesion genes | journal = Cell | volume = 97 | issue = 6 | pages = 779–90 |date=Jul 1999 | pmid = 10380929 | pmc = | doi =10.1016/S0092-8674(00)80789-8 }}</ref><ref name="pmid10662547">{{cite journal | vauthors = Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T | title = Genomic organization of the family of CNR cadherin genes in mice and humans | journal = Genomics | volume = 63 | issue = 1 | pages = 75–87 |date=Apr 2000 | pmid = 10662547 | pmc = | doi = 10.1006/geno.1999.6066 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCDHA4 protocadherin alpha 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56144| accessdate = }}</ref> | '''Protocadherin alpha-4''' is a [[protein]] that in humans is encoded by the ''PCDHA4'' [[gene]].<ref name="pmid10380929">{{cite journal | vauthors = Wu Q, Maniatis T | title = A striking organization of a large family of human neural cadherin-like cell adhesion genes | journal = Cell | volume = 97 | issue = 6 | pages = 779–90 |date=Jul 1999 | pmid = 10380929 | pmc = | doi =10.1016/S0092-8674(00)80789-8 }}</ref><ref name="pmid10662547">{{cite journal | vauthors = Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T | title = Genomic organization of the family of CNR cadherin genes in mice and humans | journal = Genomics | volume = 63 | issue = 1 | pages = 75–87 |date=Apr 2000 | pmid = 10662547 | pmc = | doi = 10.1006/geno.1999.6066 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCDHA4 protocadherin alpha 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56144| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.<ref name="entrez" /> | | summary_text = This gene is a member of the [[protocadherin]] alpha gene cluster, one of three related gene clusters tandemly linked on [[chromosome]] five that demonstrate an unusual [[genomic]] organization similar to that of [[B-cell]] and [[T-cell]] receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal [[exons]], or variable exons, are followed by downstream [[C-terminal]] exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the [[cytoplasmic]] domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.<ref name="entrez" /> | ||
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Latest revision as of 01:31, 2 June 2018
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Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.[1][2][3]
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[3]
References
- ↑ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
- ↑ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics. 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547.
- ↑ 3.0 3.1 "Entrez Gene: PCDHA4 protocadherin alpha 4".
Further reading
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
- Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- Senzaki K, Ogawa M, Yagi T (2000). "Proteins of the CNR family are multiple receptors for Reelin". Cell. 99 (6): 635–47. doi:10.1016/S0092-8674(00)81552-4. PMID 10612399.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
- Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
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