PCDH11X
Protocadherin 11 X-linked | |||||||||||
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Identifiers | |||||||||||
Symbols | PCDH11X ; PCDH-X; PCDH11; PCDHX; PCDHY; PCDH11X; PCDH22 | ||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 13194 | ||||||||||
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RNA expression pattern | |||||||||||
File:PBB GE PCDH11X 211227 s at tn.png | |||||||||||
File:PBB GE PCDH11X 217049 x at tn.png | |||||||||||
More reference expression data | |||||||||||
Orthologs | |||||||||||
Template:GNF Ortholog box | |||||||||||
Species | Human | Mouse | |||||||||
Entrez | n/a | n/a | |||||||||
Ensembl | n/a | n/a | |||||||||
UniProt | n/a | n/a | |||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||
RefSeq (protein) | n/a | n/a | |||||||||
Location (UCSC) | n/a | n/a | |||||||||
PubMed search | n/a | n/a |
Protocadherin 11 X-linked, also known as PCDH11X, is a human gene.[1]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with variable cytoplasmic domains.[1]
References
Further reading
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. PMID 10817752.
- Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Yoshida K, Sugano S (2000). "Identification of a novel protocadherin gene (PCDH11) on the human XY homology region in Xq21.3". Genomics. 62 (3): 540–3. doi:10.1006/geno.1999.6042. PMID 10644456.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMID 10716726.
- Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.
- Blanco P, Sargent CA, Boucher CA; et al. (2000). "Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain". Mamm. Genome. 11 (10): 906–14. PMID 11003707.
- Skaletsky H, Kuroda-Kawaguchi T, Minx PJ; et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
- Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
- Blanco-Arias P, Sargent CA, Affara NA (2004). "Protocadherin X ( PCDHX) and Y ( PCDHY) genes; multiple mRNA isoforms encoding variant signal peptides and cytoplasmic domains". Mamm. Genome. 15 (1): 41–52. doi:10.1007/s00335-003-3028-7. PMID 14727141.
- Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
- Wilson ND, Ross LJ, Crow TJ, Volpi EV (2006). "PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes". Cytogenet. Genome Res. 114 (2): 137–9. doi:10.1159/000093329. PMID 16825765.
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